Abstract: The present invention discloses a crystal form A of a compound, where the compound is S-(?)-2,3-methylenedioxy-5,8,13,13a-tetrahydro-10,11-dimethoxy-6H-dibenzo[a, g]quinolizine, and an X-ray powder diffraction pattern of the crystal form A includes three or more 2? values selected from the group consisting of: 12.21±0.2°, 13.381±0.2°, 15.181±0.2°, 16.171±0.2°, 17.101±0.2°, 19.801±0.2°, 21.511±0.2°, 24.391±0.2°, and 25.321±0.2°. The crystal form A of the compound of the present invention does not contain water and a solvent, has high stability and low hygroscopicity, and is suitable for patent medicine.

Abstract: The present invention discloses a crystal form A of a compound, where the compound is S-(?)-2,3-methylenedioxy-5,8,13,13a-tetrahydro-10,11-dimethoxy-6H-dibenzo[a,g]quinolizine, and an X-ray powder diffraction pattern of the crystal form A includes three or more 2? values selected from the group consisting of: 12.21±0.2°, 13.381±0.2°, 15.181±0.2°, 16.171±0.2°, 17.101±0.2°, 19.801±0.2°, 21.511±0.2°, 24.391±0.2°, and 25.321±0.2°. The crystal form A of the compound of the present invention does not contain water and a solvent, has high stability and low hygroscopicity, and is suitable for patent medicine.

Abstract: Methods registering an extravascular image with an intravascular image include obtaining a first feature information of a blood vessel segment in the intravascular image and obtaining a second feature information of a reference blood vessel in the extravascular image, where the reference blood vessel is an entire blood vessel in which the blood vessel segment is located. The methods also include performing a primary registration on the first and second feature information to obtain a third feature information that includes external contour and external branch information of a target blood vessel segment in the extravascular image, corresponding to the blood vessel segment. A secondary registration is performed on the first and third feature information to obtain a target registration result. The method can implement fast and accurate registration of the external image and the intravascular image. The methods enable a corresponding apparatus computing device, and storage medium.

Abstract: To create a 3D model of part of a cardiovascular system, two 2D images taken of different orientations of the cardiovascular system may be combined. The 2D images originate from video streams taken at different points in time, which comprise frames showing a beating heart, and thus a moving cardiovascular system. Because of this movement, not just any random set of two 2D images may result in useable 3D model. To select a proper set of two 2D images, a method is provided wherein said selection is based on cardiac cycle data. The cardiac cycle data may comprise heart activity data as a function of time and timing data on cycle events. These cycle events may be repetitive, as the same events occur with every heartbeat. The selected frames are preferably selected at, or approximately at, similar events.

Abstract: To create a 3D model of part of a cardiovascular system, two 2D images taken of different orientations of the cardiovascular system may be combined. The 2D images originate from video streams taken at different points in time, which comprise frames showing a beating heart, and thus a moving cardiovascular system. Because of this movement, not just any random set of two 2D images may result in useable 3D model. To select a proper set of two 2D images, a method is provided wherein said selection is based on cardiac cycle data. The cardiac cycle data may comprise heart activity data as a function of time and timing data on cycle events. These cycle events may be repetitive, as the same events occur with every heartbeat. The selected frames are preferably selected at, or approximately at, similar events.

Abstract: To create a 3D model of part of a cardiovascular system, two 2D images taken of different orientations of the cardiovascular system may be combined. The 2D images originate from video streams taken at different points in time, which comprise frames showing a beating heart, and thus a moving cardiovascular system. Because of this movement, not just any random set of two 2D images may result in useable 3D model. To select a proper set of two 2D images, a method is provided wherein said selection is based on cardiac cycle data. The cardiac cycle data may comprise heart activity data as a function of time and timing data on cycle events. These cycle events may be repetitive, as the same events occur with every heartbeat. The selected frames are preferably selected at, or approximately at, similar events.

Abstract: A method for obtaining vascular pressure difference includes: receiving anatomical data of a part of a blood vessel segment, obtaining a geometric model of a target blood vessel according to the anatomical data; combining individual data according to the anatomical data to obtain a blood flow model of the target blood vessel and the target blood vessel blood flow velocity V; preprocess the geometric model to establish a cross-sectional morphology model, calculate the morphological difference function f(x) of the target vessel lumen, calculate the pressure difference at any two positions of the target vessel based on morphology ?P the difference of the target vessel lumen the relationship between function f(x) and blood flow velocity V. The method of obtaining the vascular pressure difference, by introducing the concept of morphology, the influence of the vascular morphology on the vascular pressure difference is clarified, improve the calculation accuracy of vascular pressure difference.

Abstract: To create a 3D model of part of a cardiovascular system, two 2D images taken of different orientations of the cardiovascular system may be combined. The 2D images originate from video streams taken at different points in time, which comprise frames showing a beating heart, and thus a moving cardiovascular system. Because of this movement, not just any random set of two 2D images may result in useable 3D model. To select a proper set of two 2D images, a method is provided wherein said selection is based on cardiac cycle data. The cardiac cycle data may comprise heart activity data as a function of time and timing data on cycle events. These cycle events may be repetitive, as the same events occur with every heartbeat. The selected frames are preferably selected at, or approximately at, similar events.

Abstract: Deviations of blood pressure due to stenosis caused by plaque pose a health risk. The deviation, often expressed in a fractional flow reserve, may be calculated on a per-location basis using deviations of the local cross-sectional area or local diameter from a reference value representing a healthy vessel. The reference value may be obtained by means of linear or higher order interpolation or linear regression techniques. Together with the flow velocity of a fluid through the vessel, a value of local deviation of a vessel geometry compared to a reference value allows for accurate, fast and efficient calculation of the fractional flow reserve for every location of the vessel for which geometry data is available. The reference value as well as actual data obtained by measurements may be represented or approximated by functions, allowing accurate and efficient calculation of data over a continuous region of the segment under scrutiny.

Abstract: The invention provides quinazoline-7-ether derivatives, particularly 4-anilinyl-6-butenamido-quinazoline-7-ether derivatives that are inhibitors of the receptor protein tyrosine kinases (RTK). The compounds are useful in the treatment of diseases and disorders where RTK activity is implicated such as a hyperproliferative diseases (e.g., cancer). Also provided are methods of preparation of the quinazoline derivatives and methods of use as therapeutic agents alone or in a drug combination.

Abstract: Deviations of blood pressure due to stenosis caused by plaque pose a health risk. The deviation, often expressed in a fractional flow reserve, may be calculated on a per-location basis using deviations of the local cross-sectional area or local diameter from a reference value representing a healthy vessel. The reference value may be obtained by means of linear or higher order interpolation or linear regression techniques. Together with the flow velocity of a fluid through the vessel, a value of local deviation of a vessel geometry compared to a reference value allows for accurate, fast and efficient calculation of the fractional flow reserve for every location of the vessel for which geometry data is available. The reference value as well as actual data obtained by measurements may be represented or approximated by functions, allowing accurate and efficient calculation of data over a continuous region of the segment under scrutiny.

Abstract: The invention provides quinazoline-7-ether derivatives, particularly 4-anilinyl-6-butenamido-quinazoline-7-ether derivatives that are inhibitors of the receptor protein tyrosine kinases (RTK). The compounds are useful in the treatment of diseases and disorders where RTK activity is implicated such as a hyperproliferative diseases (e.g., cancer). Also provided are methods of preparation of the quinazoline derivatives and methods of use as therapeutic agents alone or in a drug combination.