Abstract: The present invention relates to a pharmaceutical composition comprising a ?-lactam compound of formula (I), or a stereoisomer, a solvate or a pharmaceutically acceptable salt or ester thereof, and a lactamase inhibitor or an efflux pump inhibitor, and the use thereof for inhibiting microorganisms, particularly bacteria, especially Gram-negative bacteria, wherein each symbol in formula (I) is as defined in the description.

Abstract: The present invention relates to a compound as shown in general formula (I) below (in formula (I), each of R1 and R2 independently represents a hydrogen atom or a C1-10 linear or branched alkyl optionally having a substituent, or the two together form a cycloalkyl with 3 to 8 ring carbon atoms; each of R3 and R4 independently represents a hydrogen atom or a C1-10 linear or branched alkyl optionally having a substituent or a C6-12 aryl optionally having a substituent, or the two together form a cycloalky with 3 to 8 ring carbon atoms; X represents C or N; and Y represents a linear or branched alkenyl or alkynyl with 2 to 6 carbon atoms and optionally having a substituent, or carboxyl). The compound has good antibacterial properties against bacteria, especially gram-negative bacteria, has low drug resistance, and has good prospects for the effective treatment of various conditions.

Abstract: A method and apparatus for nanocrystallizing a metal surface by laser-induced shock wave-accelerated nanoparticles. The apparatus comprises a control system, a light guiding system, a workbench control system and an auxiliary system, wherein the auxiliary system comprises an air compressor, a paint feeder device, a nanoparticle nozzle, a powder feeder device, an exhaust, a sealed working chamber and a metal nanoparticle recycler device. The method comprises the following steps: pre-processing and fixing a workpiece; activating the air compressor to feed a powder; controlling and adjusting the paint feeder device to eject a black paint; transmitting a high-power pulse laser beam; recycling excess metal nanoparticles; and rinsing non-vaporized/ionized black paint off a surface of the workpiece.

Abstract: The invention novel compounds, pharmaceutical compositions and methods useful for preventing or treating cancer in animals and humans. Also, the invention provides novel prodrugs useful for reducing tumor size, and inhibiting the growth of cancers, inhibiting tumor cell growth and tumor cell proliferation, and promoting apoptosis of tumor cells. When used in combination with chemoradiation therapy, the novel compounds, compositions and prodrugs provided herein can improve the effectiveness of chemoradiation therapy. The novel compounds, compositions and prodrugs of the invention inhibit PDK and LDH in unique and effective ways.

Abstract: A method and apparatus for acquiring a nanostructured coating on a metal surface by using an intense shock wave generated by continuous explosion of a laser-induced plasma is provided. The method comprises: irradiating a laser beam on a black paint surface of an upper opening of a high pressure resistant glass pipe having a black paint strip arranged therein; the black paint absorbing the light energy and producing a plasma; generating an initial plasma explosion shock wave; transmitting the initial plasma explosion shock wave in the high pressure resistant glass pipe; generating a plasma cloud reaching a lower opening of a glass catheter; and, the shock wave pressure outputted embedding nanoparticles into a surface of a workpiece. The apparatus comprises the high pressure-resistant glass pipe with a zigzagging switchback shape or a spiral and inverted cone shape.

Abstract: The invention novel compounds, pharmaceutical compositions and methods useful for preventing or treating cancer in animals and humans. Also, the invention provides novel prodrugs useful for reducing tumor size, and inhibiting the growth of cancers, inhibiting tumor cell growth and tumor cell proliferation, and promoting apoptosis of tumor cells. When used in combination with chemoradiation thereapy, the novel compounds, compositions and prodrugs provided herein can improve the effectiveness of chemoradiation therapy. The novel compounds, compositions and prodrugs of the invention inhibit PDK and LDH in unique and effective ways.

Abstract: A method and apparatus for acquiring a nanostructured coating on a metal surface by using an intense shock wave generated by continuous explosion of a laser-induced plasma is provided. The method comprises: irradiating a laser beam on a black paint surface of an upper opening of a high pressure resistant glass pipe having a black paint strip arranged therein; the black paint absorbing the light energy and producing a plasma; generating an initial plasma explosion shock wave; transmitting the initial plasma explosion shock wave in the high pressure resistant glass pipe; generating a plasma cloud reaching a lower opening of a glass catheter; and, the shock wave pressure outputted embedding nanoparticles into a surface of a workpiece. The apparatus comprises the high pressure-resistant glass pipe with a zigzagging switchback shape or a spiral and inverted cone shape.

Abstract: A method and apparatus for nanocrystallizing a metal surface by laser-induced shock wave-accelerated nanoparticles. The apparatus comprises a control system, a light guiding system, a workbench control system and an auxiliary system, wherein the auxiliary system comprises an air compressor, a paint feeder device, a nanoparticle nozzle, a powder feeder device, an exhaust, a sealed working chamber and a metal nanoparticle recycler device. The method comprises the following steps: pre-processing and fixing a workpiece; activating the air compressor to feed a powder; controlling and adjusting the paint feeder device to eject a black paint; transmitting a high-power pulse laser beam; recycling excess metal nanoparticles; and rinsing non-vaporized/ionized black paint off a surface of the workpiece.

Abstract: A tissue culture device includes a container having one or more upstanding walls extending upwardly from a floor. The floor of the container has a media having nutrients or growth substances therein. A plurality of plant tissues are within the container compartment and are placed upon a screen between the plant tissues and the media. The screen is tamped downwardly onto the media so that the plant tissues can get nutrients from the media, and so that waste products are transferred into the media. The screen is also removable through the open end of the container so as to remove all of the plurality of the plant tissues from the container at once. The plant tissue device can then be placed in another container having any cultured media as needed for the correct maintenance, propagation and development of plant tissue in culture.

Abstract: An air exchange system places the air pumps or fans outside of the main air outflow pathway through a device, such as a range hood. By using this configuration, the system is made safe, easy to maintain with less noise and may even increase the efficiency of the air pump by not subjecting it to debris, particles or turbulence in the air flow, also flexible to add more pumps with significant increase the size of the air exchange system. Air pumps can be operably connected to push air into two or more air reservoirs. Each air reservoir has a narrow air outlet slit along with a Coanda design. When air comes out of the narrow air outlet, it has high speed and generates a negative pressure due to the Bernoulli effect. Such negative pressure will bring more air around into the air flow system, thus causing a desired air exchange.

Abstract: Methods are provided for transforming isolated, immature maize embryos and for producing transgenic maize plants. The methods additionally comprise identifying or selecting transformed cells and regenerating such cells into transformed maize plants.

Abstract: The methods provided relate to efficient methods for transforming isolated, immature maize embryos and for producing transgenic maize plantlets. The time required for the production of the transgenic plantlets and subsequent plants is significantly decreased compared to conventional methods. The methods also relate to decreasing the selection time of transgenic events and regenerating a transgenic maize plantlet from transgenic somatic embryos from the events in a plant cell culture vessel that allows for root formation and plantlet elongation in the same plant cell culture vessel.

Abstract: A tissue culture device includes a container having one or more upstanding walls extending upwardly from a floor. The floor of the container has a media having nutrients or growth substances therein. A plurality of plant tissues are within the container compartment and are placed upon a screen between the plant tissues and the media. The screen is tamped downwardly onto the media so that the plant tissues can get nutrients from the media, and so that waste products are transferred into the media. The screen is also removable through the open end of the container so as to remove all of the plurality of the plant tissues from the container at once. The plant tissue device can then be placed in another container having any cultured media as needed for the correct maintenance, propagation and development of plant tissue in culture.