Patents by Inventor Yinghu HU

Yinghu HU has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Crystal form A of 2-butoxy-7-(4-(pyrrolidin-1-ylmethyl)benzyl)-5H-pyrrolo[3,2-d]pyrimidin-4-amine for inhibiting toll-like receptor activity
    Patent number: 10947245
    Abstract: The present invention relates to crystalline form A of a TLR7 agonist 2-butoxy-7-(4-(pyrrolidin-1-ylmethyl)-benzyl)-5H-pyrrolo[3,2-d]pyrimidin-4-amine (formula I), a method for preparing the crystalline form A, and the use thereof.
    Type: Grant
    Filed: September 25, 2019
    Date of Patent: March 16, 2021
    Assignee: CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD.
    Inventors: Zhaozhong Ding, Fei Sun, Yinghu Hu, Yilong Zhou, Zheng Wang, Rui Zhao, Ling Yang
  • TLR7 AGONIST MALEATE SALT, CRYSTALLINE FORMS C, D AND E THEREOF, PREPARATION METHODS AND USES OF MALEATE SALT AND CRYSTALLINE FORMS
    Publication number: 20200368241
    Abstract: The present invention relates to a maleate salt of a compound represented by formula I, a method for preparing the salt, a pharmaceutical composition containing the salt, and the use of the salt. The present invention also relates to crystalline forms C, D and E of the maleate salt of the compound represented by formula I, methods for preparing the crystalline forms, crystalline compositions and pharmaceutical compositions containing the crystalline forms, and uses thereof.
    Type: Application
    Filed: August 12, 2020
    Publication date: November 26, 2020
    Inventors: Zhaozhong DING, Fei SUN, Yinghu HU, Yilong ZHOU, Zheng WANG, Ling YANG
  • TLR7 agonist maleate salt, crystalline forms C, D and E thereof, preparation methods and uses of maleate salt and crystalline forms
    Patent number: 10780091
    Abstract: The present invention relates to a maleate salt of a compound represented by formula I, a method for preparing the salt, a pharmaceutical composition containing the salt, and the use of the salt. The present invention also relates to crystalline forms C, D and E of the maleate salt of the compound represented by formula I, methods for preparing the crystalline forms, crystalline compositions and pharmaceutical compositions containing the crystalline forms, and uses thereof.
    Type: Grant
    Filed: February 4, 2017
    Date of Patent: September 22, 2020
    Assignee: CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD.
    Inventors: Zhaozhong Ding, Fei Sun, Yinghu Hu, Yilong Zhou, Zheng Wang, Ling Yang
  • METHOD FOR PREPARING PYRROLO[3,2,-D]PYRIMIDINE COMPOUND, AND INTERMEDIATES THEREOF
    Publication number: 20200239484
    Abstract: The present invention relates to a method for preparing a pyrrolo[3,2-d]pyrimidine compound (the compound represented by formula I), and corresponding intermediates.
    Type: Application
    Filed: April 13, 2020
    Publication date: July 30, 2020
    Inventors: Zhaozhong DING, Fei SUN, Yinghu HU, Yilong ZHOU, Rui ZHAO, Ling YANG
  • TLR7 agonist trifluoroacetate salt and crystalline form B thereof, preparation methods and uses
    Patent number: 10683296
    Abstract: The present invention relates to a trifluoroacetate salt of a TLR7 agonist 2-butoxy-7-(4-(pyrrolidin-1-ylmethyl)benzyl)-5H-pyrrolo[3,2-d]pyrimidin-4-amine (formula I), crystalline form B of the trifluoroacetate salt, methods for preparing the trifluoroacetate salt and crystalline form B, and uses of the trifluoroacetate salt and crystalline form B.
    Type: Grant
    Filed: February 4, 2017
    Date of Patent: June 16, 2020
    Assignee: CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD.
    Inventors: Zhaozhong Ding, Fei Sun, Yinghu Hu, Yilong Zhou, Zheng Wang, Rui Zhao, Ling Yang
  • Method for preparing pyrrolo[3,2-D]pyrimidine compound, and intermediates thereof
    Patent number: 10654856
    Abstract: The present invention relates to a method for preparing a pyrrolo[3,2-d]pyrimidine compound (the compound represented by formula I), and corresponding intermediates.
    Type: Grant
    Filed: February 4, 2017
    Date of Patent: May 19, 2020
    Assignee: CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD.
    Inventors: Zhaozhong Ding, Fei Sun, Yinghu Hu, Yilong Zhou, Rui Zhao, Ling Yang
  • TLR7 AGONIST CRYSTALLINE FORM A, PREPARATION METHOD AND USE THEREOF
    Publication number: 20200039988
    Abstract: The present invention relates to crystalline form A of a TLR7 agonist 2-butoxy-7-(4-(pyrrolidin-1-ylmethyl)-benzyl)-5H-pyrrolo[3,2-d]pyrimidin-4-amine (formula I), a method for preparing the crystalline form A, and the use thereof.
    Type: Application
    Filed: September 25, 2019
    Publication date: February 6, 2020
    Inventors: Zhaozhong DING, Fei SUN, Yinghu HU, Yilong ZHOU, Zheng WANG, Rui ZHAO, Ling YANG
  • Crystal form A of 2-butoxy-7-(4-(pyrrolidin-1-ylmethyl)benzyl)-5H-pyrrolo[3,2-D] pyrimidin-4-amine, preparation process and use thereof
    Patent number: 10442811
    Abstract: The present invention relates to crystalline form A of a TLR7 agonist 2-butoxy-7-(4-(pyrrolidin-1-ylmethyl)-benzyl)-5H-pyrrolo[3,2-d]pyrimidin-4-amine (formula I), a method for preparing the crystalline form A, and the use thereof.
    Type: Grant
    Filed: February 4, 2017
    Date of Patent: October 15, 2019
    Assignee: CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD.
    Inventors: Zhaozhong Ding, Fei Sun, Yinghu Hu, Yilong Zhou, Zheng Wang, Rui Zhao, Ling Yang
  • CRYSTAL AND SALT OF NITROIMIDAZOLE, AND MANUFACTURING METHOD THEREOF
    Publication number: 20190276475
    Abstract: The present invention discloses a crystal form and salt of a nitroimidazole compound, and a manufacturing method thereof. The invention further comprises an application of the crystal form and salt in preparing a pharmaceutical product for preventing and treating an infection caused by Mycobacterium tuberculosis or another microbe.
    Type: Application
    Filed: July 21, 2017
    Publication date: September 12, 2019
    Applicant: Medshine Discovery Inc.
    Inventors: Wei LUO, Charles Z. DING, Zhigang HUANG, Yinghu HU, Zongbin LI, Qingqing LU
  • TLR7 AGONIST MALEATE SALT, CRYSTALLINE FORMS C, D AND E THEREOF, PREPARATION METHODS AND USES OF MALEATE SALT AND CRYSTALLINE FORMS
    Publication number: 20190070179
    Abstract: The present invention relates to a maleate salt of a compound represented by formula I, a method for preparing the salt, a pharmaceutical composition containing the salt, and the use of the salt. The present invention also relates to crystalline forms C, D and E of the maleate salt of the compound represented by formula I, methods for preparing the crystalline forms, crystalline compositions and pharmaceutical compositions containing the crystalline forms, and uses thereof.
    Type: Application
    Filed: February 4, 2017
    Publication date: March 7, 2019
    Inventors: Zhaozhong DING, Fei SUN, Yinghu HU, Yilong ZHOU, Zheng WANG, Ling YANG
  • TLR7 AGONIST CRYSTALLINE FORM A, PREPARATION METHOD AND USE THEREOF
    Publication number: 20190040071
    Abstract: The present invention relates to crystalline form A of a TLR7 agonist 2-butoxy-7-(4-(pyrrolidin-1-ylmethyl)-benzyl)-5H-pyrrolo[3,2-d]pyrimidin-4-amine (formula I), a method for preparing the crystalline form A, and the use thereof.
    Type: Application
    Filed: February 4, 2017
    Publication date: February 7, 2019
    Inventors: Zhaozhong DING, Fei SUN, Yinghu HU, Yilong ZHOU, Zheng WANG, Rui ZHAO, Ling YANG
  • METHOD FOR PREPARING PYRROLO[3,2-D]PYRIMIDINE COMPOUND, AND INTERMEDIATES THEREOF
    Publication number: 20190040072
    Abstract: The present invention relates to a method for preparing a pyrrolo[3,2-d]pyrimidine compound (the compound represented by formula I), and corresponding intermediates.
    Type: Application
    Filed: February 4, 2017
    Publication date: February 7, 2019
    Inventors: Zhaozhong DING, Fei SUN, Yinghu HU, Yilong ZHOU, Rui ZHAO, Ling YANG
  • TLR7 AGONIST TRIFLUOROACETATE SALT AND CRYSTALLINE FORM B THEREOF, PREPARATION METHODS AND USES
    Publication number: 20190031666
    Abstract: The present invention relates to a trifluoroacetate salt of a TLR7 agonist 2-butoxy-7-(4-(pyrrolidin-1-ylmethyl)benzyl)-5H-pyrrolo[3,2-d]pyrimidin-4-amine (formula I), crystalline form B of the trifluoroacetate salt, methods for preparing the trifluoroacetate salt and crystalline form B, and uses of the trifluoroacetate salt and crystalline form B.
    Type: Application
    Filed: February 4, 2017
    Publication date: January 31, 2019
    Inventors: Zhaozhong DING, Fei SUN, Yinghu HU, Yilong ZHOU, Zheng WANG, Rui ZHAO, Ling YANG