Abstract: Provided is the use of compounds of Formula I, as well as certain specific compounds, or a pharmaceutically acceptable salt, solvate or derivative thereof, in the preparation of a medicament to treat or prevent a disease condition that is associated with increased KCa3.1 or altered activity, such as stroke.

Abstract: A portable blowing alcohol concentration measuring device is provided, including: a housing, a valve body, a first one-way valve, a second one-way valve and a container. The first one-way valve can be opened and closed between the air inlet of the housing and the valve body; a container is provided at the other end of the housing, and the housing and the container are spaced by a PTFE membrane; the second one-way valve has a suction port connected to a drainage port on the container. The opening and closing of the second one-way valve can make the passage between the suction port and the inside of the valve body to achieve a pass-through. By optimizing the structure and testing method, the alcohol in the exhaled gas is fully dissolved in the solution in the container, and the blood alcohol concentration can be obtained by direct measurement using the fitted function.