Abstract: A laser fusion welding device includes a 1.9 ?m laser light source, a control unit and a light spot adjusting device. The control unit is configured to control the laser light source and the light spot adjusting device to adjust a laser power density at an object to be subjected to fusion welding. The 1.9 ?m laser light source has output power of 100-500 W. The control unit includes a time control unit, a power control unit and a light spot control unit. The time control unit is configured to control a turn-on time of the laser light source. The power control unit is configured to control the output power of the laser light source. The light spot control unit is configured to control the light spot adjusting device to adjust a size of a light spot at the object to be subjected to fusion welding.

Abstract: A method for measuring concentrations of multiple gases by using an infrared band laser light includes: pumping Ho crystal by using a 1.9 ?m single thulium-doped solid-state laser to obtain a 2 ?m band near-infrared laser output; controlling a light-emitting angle of 2 ?m band laser light; allowing the 2 ?m laser light to enter a first measurement cell at a first emergent angle, and measuring a concentration of methane gas in the first measurement cell; generating and introducing the 3-5 ?m mid-infrared laser light into a second measurement cell to measure concentrations of ammonia gas and carbon monoxide in the second measurement cell; generating and introducing the 6-12 ?m far-infrared laser light into a third measurement cell to measure concentrations of carbon dioxide, acetylene, ethylene and ethane gas in the third measurement cell.

Abstract: A method for measuring multiple parameters of mixed gases based on broadband infrared light source is provided, including: filtering a broadband infrared laser, and forming a laser beam including three narrow-linewidth wavelengths; dividing the laser beam into a first sub-laser beam and a second sub-laser beam; focusing and transmitting the first sub-laser beam to a gas sample cell; focusing and transmitting the first sub-laser beam to a first reflector; reflecting and transmitting the first sub-laser beam; reflecting and transmitting the second sub-laser beam to the second beam splitter; combing the first sub-laser beam transmitted by the second beam splitter and the second sub-laser beam reflected by the second beam splitter, measuring the multiple parameters; combining and transmitting the second sub-laser beam transmitted by the second beam splitter and the first sub-laser beam reflected by the second beam splitter to a spectrometer for measuring concentrations the mixed gases.

Abstract: A fiber optic sensing head includes a single-mode optical fiber, a twin hole optical fiber including a cladding region and a core region surrounded by the cladding region, and the core region includes a second core located at an axis center, as well as a first and second round holes symmetrically distributed with respect to the second core; an incoming end of a gradient refractive-index fiber is connected to an outgoing end of the twin hole optical fiber with the incoming end of the gradient index fiber aligned with the outgoing end of the single-mode optical fiber at center. A thermal-sensitive structure is filled in a preset length part of the second round hole extending along an axial direction of the twin hole optical fiber. An incoming end of the twin hole optical fiber is connected to an outgoing end of the gradient index optical fiber with displacement.

Abstract: Disclosed herein are compositions and methods for treating and preventing neurodegenerative diseases, such as Alzheimer's disease. In some embodiments, the composition comprises a peptide that disrupts the binding between PTP? and APP, preventing ?-amyloidogenic processing of APP without affecting other major substrates of ?- and ?-secretases. Alternatively, in some embodiments, an antibody or a fragment of an antibody against PTP? or APP may be used to disrupt the binding between PTP? and APP. In some embodiments, the composition comprises compounds or enzymes, which restore perineuronal balance of PTP? ligands CS and HS, thereby preventing abnormally increased ?-amyloidogenic processing of APP. Compositions and methods disclosed herein can be used in combination to treat and prevent neurodegenerative diseases.

Abstract: A method inhibiting and/or reducing ?-amyloid accumulation and/or Tau aggregation in a subject in need thereof includes administering to the subject a therapeutic agent that inhibits one or more of catalytic activity, signaling, and function of the LAR family phosphatases.

Abstract: Disclosed herein are compositions and methods for treating and preventing neurodegenerative diseases, such as Alzheimer's disease. In some embodiments, the composition comprises a peptide that disrupts the binding between PTP? and APP, preventing ?-amyloidogenic processing of APP without affecting other major substrates of ?- and ?-secretases. Alternatively, in some embodiments, an antibody or a fragment of an antibody against PTP? or APP may be used to disrupt the binding between PTP? and APP. In some embodiments, the composition comprises compounds or enzymes, which restore perineuronal balance of PTP? ligands CS and HS, thereby preventing abnormally increased ?-amyloidogenic processing of APP. Compositions and methods disclosed herein can be used in combination to treat and prevent neurodegenerative diseases.

Abstract: Disclosed herein are methods of inducing neuronal outgrowth of a neuron. The methods comprise contacting the neuron with an agent that binds receptor protein tyrosine phosphatase ? (RPTP?), to thereby induce neuronal outgrowth of the neuron. The agent may induces clustering of RPTP? and/or inhibit binding of chondroitin sulfate proteoglycan (CSPG) to RPTP?. Examples of suitable agents are heparan sulfate proteoglycan, heparan sulfate, heparan sulfate oligosaccharides, or heparin oligosaccharides. Additional agents are also disclosed. The neuron can be a CNS neuron or peripheral neuron. Also disclosed herein are methods of treating neuronal injury in a subject comprising, administering to the subject an agent that binds RPTP?. Administration may be to a site of neuronal injury, to thereby induce neuronal outgrowth at the site of neuronal injury.

Abstract: Disclosed herein are methods of inducing neuronal outgrowth of a neuron. The methods comprise contacting the neuron with an agent that binds receptor protein tyrosine phosphatase ? (RPTP?), to thereby induce neuronal outgrowth of the neuron. The agent may induces clustering of RPTP? and/or inhibit binding of chondroitin sulfate proteoglycan (CSPG) to RPTP?. Examples of suitable agents are heparan sulfate proteoglycan, heparan sulfate, heparan sulfate oligosaccharides, or heparin oligosaccharides. Additional agents are also disclosed. The neuron can be a CNS neuron or peripheral neuron. Also disclosed herein are methods of treating neuronal injury in a subject comprising, administering to the subject an agent that binds RPTP?. Administration may be to a site of neuronal injury, to thereby induce neuronal outgrowth at the site of neuronal injury.

Abstract: A method of promoting neural cell regeneration is carried out by contacting a neural cell with a compound that inhibits the binding of a chondroitin sulfate proteoglycan (CSPG) to a cellular (e.g., trans-membrane) PTP? protein. The neural cell is associated with an injury or neurodegenerative condition.