Patents by Inventor Yingjuan J. LU

Yingjuan J. LU has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compositions and methods for CAR T cell therapy
    Patent number: 11850262
    Abstract: The present disclosure relates to methods of treating a patient with a cancer by administering to the patient a composition comprising CAR T cells and a small molecule linked to a targeting moiety by a linker. The disclosure also relates to compositions for use in such methods.
    Type: Grant
    Filed: February 28, 2018
    Date of Patent: December 26, 2023
    Assignees: Purdue Research Foundation, Endocyte, Inc.
    Inventors: Philip Stewart Low, Haiyan Chu, Yong Gu Lee, Yingjuan J. Lu, Christopher Paul Leamon, Leroy W. Wheeler, II
  • Compositions and methods for CAR T cell therapy
    Patent number: 11759480
    Abstract: The present disclosure relates to methods of treating a patient with a cancer by administering to the patient a composition comprising CAR T cells and a small molecule linked to a targeting moiety by a linker. The disclosure also relates to compositions for use in such methods.
    Type: Grant
    Filed: July 6, 2020
    Date of Patent: September 19, 2023
    Assignees: ENDOCYTE, INC., PURDUE RESEARCH FOUNDATION
    Inventors: Philip Stewart Low, Haiyan Chu, Yong Gu Lee, Yingjuan J. Lu, Christopher Paul Leamon, Leroy W Wheeler, II
  • METHODS OF TREATING CANCER BY TARGETING TUMOR-ASSOCIATED MACROPHAGES
    Publication number: 20220175875
    Abstract: Methods for treating cancers using one or more compounds comprising a folate receptor binding ligand attached to a drug via a linker are described. Methods for treating cancers using one or more compounds comprising a folate receptor binding ligand attached to a drug via a linker to target tumor associated macrophages are described.
    Type: Application
    Filed: November 11, 2021
    Publication date: June 9, 2022
    Inventors: Yingjuan J. LU, Leroy W. WHEELER, II, Philip Stewart LOW, Christopher Paul LEAMON
  • ANTIFOLATE CONJUGATES FOR TREATING INFLAMMATION
    Publication number: 20210069340
    Abstract: The present invention relates to compositions and methods for use in targeted drug delivery. More particularly, the invention is directed to cell-surface receptor binding conjugates containing hydrophilic spacer linkers for use in treating disease states caused by pathogenic cell populations and to methods and pharmaceutical compositions that use and include such conjugates.
    Type: Application
    Filed: July 16, 2020
    Publication date: March 11, 2021
    Inventors: Iontcho Radoslavov VLAHOV, Christopher Paul LEAMON, Fei YOU, Yingjuan J. LU, Paul Joseph KLEINDL
  • COMPOSITIONS AND METHODS FOR CAR T CELL THERAPY
    Publication number: 20200405760
    Abstract: The present disclosure relates to methods of treating a patient with a cancer by administering to the patient a composition comprising CAR T cells and a small molecule linked to a targeting moiety by a linker. The disclosure also relates to compositions for use in such methods.
    Type: Application
    Filed: July 6, 2020
    Publication date: December 31, 2020
    Inventors: Philip Stewart LOW, Haiyan CHU, Yong Gu LEE, Yingjuan J. LU, Christopher Paul LEAMON, Leroy W WHEELER
  • PBD CONJUGATES FOR TREATING DISEASES
    Publication number: 20200323991
    Abstract: The present disclosure relates to pyrrolobenzodiazepine (PBD) prodrugs and conjugates thereof. The present disclosure also relates to pharmaceutical compositions of the conjugates described herein, methods of making and methods of using the same.
    Type: Application
    Filed: March 29, 2017
    Publication date: October 15, 2020
    Inventors: Iontcho Radoslavov VLAHOV, Christopher Paul LEAMON, Longwu QI, Ning ZOU, Kevin Yu WANG, Albert E. FELTEN, Garth L. PARHAM, Fei YOU, Hari Krishna R. SANTHAPURAM, Spencer J. HAHN, Joseph Anand REDDY, Yingjuan J. LU, Leroy W. WHEELER, II
  • FOLATE CONJUGATE FOR USE IN TARGETING TUMOR ASSOCIATED MACROPHAGES
    Publication number: 20200038514
    Abstract: Methods are provided for treating cancers using a conjugate herein described as Conjugate 5, or a pharmaceutically acceptable salt thereof. Methods for treating cancers using Conjugate 5, or a pharmaceutically acceptable salt thereof, to target tumor associated macrophages are also described.
    Type: Application
    Filed: September 14, 2017
    Publication date: February 6, 2020
    Inventors: Iontcho Radoslavov VLAHOV, Christopher Paul LEAMON, Longwu QI, Ning ZOU, Kevin Yu WANG, Albert E. FELTEN, Garth L. PARHAM, Fei YOU, Hari Krishna R. SANTHAPURAM, Spencer J. HAHN, Joseph Anand REDDY, Yingjuan J. LU, Leroy W. WHEELER, II
  • COMPOSITIONS AND METHODS FOR CAR T CELL THERAPY
    Publication number: 20200023009
    Abstract: The present disclosure relates to methods of treating a patient with a cancer by administering to the patient a composition comprising CAR T cells and a small molecule linked to a targeting moiety by a linker. The disclosure also relates to compositions for use in such methods.
    Type: Application
    Filed: February 28, 2018
    Publication date: January 23, 2020
    Inventors: Philip Stewart LOW, Haiyan CHU, Yong Gu LEE, Yingjuan J. LU, Christopher Paul LEAMON, Leroy W. WHEELER, II
  • ANTIFOLATE CONJUGATES FOR TREATING INFLAMMATION
    Publication number: 20180280528
    Abstract: The present invention relates to compositions and methods for use in targeted drug delivery. More particularly, the invention is directed to cell-surface receptor binding conjugates containing hydrophilic spacer linkers for use in treating disease states caused by pathogenic cell populations and to methods and pharmaceutical compositions that use and include such conjugates.
    Type: Application
    Filed: April 29, 2016
    Publication date: October 4, 2018
    Inventors: Iontcho Radoslavov VLAHOV, Christopher Paul LEAMON, Fei YOU, Yingjuan J. LU, Paul Joseph KLEINDL
  • METHODS OF TREATING CANCER BY TARGETING TUMOR-ASSOCIATED MACROPHAGES
    Publication number: 20170266303
    Abstract: Methods for treating cancers using one or more compounds comprising a folate receptor binding ligand attached to a drug via a linker are described. Methods for treating cancers using one or more compounds comprising a folate receptor binding ligand attached to a drug via a linker to target tumor associated macrophages are described.
    Type: Application
    Filed: November 24, 2015
    Publication date: September 21, 2017
    Inventors: Yingjuan J. LU, Leroy W. WHEELER, II, Philip Stewart LOW, Christopher Paul LEAMON