Patents by Inventor Ying-Ren Wang

Ying-Ren Wang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Crystals of human topoisomerase II-DNA binary complex, methods for preparing the same and uses thereof
    Patent number: 8765443
    Abstract: Disclosed herein are a crystal of a human TOPII (hTOPII)-DNA binary complex, the method for preparing the same and the use thereof. The hTOPII-DNA binary complex includes an hTOPII portion that contains an hTOPII core domain (hTOPIIcore), and a synthetic double-stranded DNA in complex with the hTOPII portion. The synthetic double-stranded DNA has a first DNA strand comprising nucleotide positions 3 to 20 of the sequence of 5?-NNNCCGAGCNNNNGCTCGGNNN-3? (SEQ ID NO: 1), wherein N is any one of adenine, thymine, cytosine, or guanine, and a second DNA strand complementary to the first DNA strand.
    Type: Grant
    Filed: July 24, 2012
    Date of Patent: July 1, 2014
    Assignee: National Taiwan University
    Inventors: Nei-Li Chan, Tsai-Kun Li, Chyuan-Chuan Wu, Ying-Ren Wang
  • CRYSTALS OF HUMAN TOPOISOMERASE II-DNA BINARY COMPLEX, METHODS FOR PREPARING THE SAME AND USES THEREOF
    Publication number: 20130018180
    Abstract: Disclosed herein are a crystal of a human TOPII (hTOPII)-DNA binary complex, the method for preparing the same and the use thereof. The hTOPII-DNA binary complex includes an hTOPII portion that contains an hTOPII core domain (hTOPIIcore), and a synthetic double-stranded DNA in complex with the hTOPII portion. The synthetic double-stranded DNA has a first DNA strand comprising nucleotide positions 3 to 20 of the sequence of 5?-NNNCCGAGCNNNNGCTCGGNNN-3? (SEQ ID NO: 1), wherein N is any one of adenine, thymine, cytosine, or guanine, and a second DNA strand complementary to the first DNA strand.
    Type: Application
    Filed: July 24, 2012
    Publication date: January 17, 2013
    Applicant: National Taiwan University
    Inventors: Nei-Li CHAN, Tsai-Kun Li, Chyuan-Chuan Wu, Ying-Ren Wang