Abstract: Methods and systems are described herein for determining data shifts using change point detection in time series datasets. The system receives, from a change point modelling system, a first model and a plurality of change points detected within a time series dataset using the first model. The system generates, for each change point, a second corresponding model that fails to detect a corresponding change point and inputs the time series dataset into the first model and into each second corresponding model. The system determines a performance difference between the first model and each second corresponding model and assigns severity metrics to the change points based on the corresponding performance difference. The system selects a subset of change points based on the severity metrics and determines a cause of each change point of the subset of change points.

Abstract: The invention belongs to the field of biotechnology and medicine, and particularly relates to the application of an inhibitor of circIKBKB and a testing reagent thereof in diagnosis, treatment and prognosis kits of breast cancer bone metastasis. The kit includes one of RT-PCR, Q-PCR, Northern blot, FISH or ISH kits. The kit includes the primers shown in SEQ ID Nos. 1-2 in the sequence listing or the probe shown in SEQ ID NO. 3 in the sequence listing for the back-splice junction sequences for circIKBKB. An antisense oligonucleotide targeting the linker sequence of circIKBKB is used as a reagent for inhibiting the generation of circIKBKB and for the preparation of a drug for the treatment of breast cancer bone metastasis. The eIF4A3-IN-2 inhibitor is used for the preparation of a treatment for breast cancer bone metastasis drug.