Abstract: A macrocyclic TLR7 agonist, a preparation method therefor, a pharmaceutical composition and use thereof. The macrocyclic TLR7 agonist disclosed is as represented by formula I, has good TLR7 agonistic activity, and can be used for treating or preventing tumors or infections caused by viruses.

Abstract: Provided herein are organic solvent-based processes for the removal of rubber from non-Hevea plants such as guayule shrubs. By the use of the processes, solid purified rubber can be obtained that contains 0.05-0.5 weight % dirt, 0.2-1.5 weight % ash, and 0.1-4 weight % resin (when it has been dried so as to contain 0.8 weight % volatile matter).

Abstract: A method for forming a polymer-filler composite having advantageous bound filler content, the method comprising (a) providing a guayule cement; (b) introducing particulate filler to the guayule cement to form a solution masterbatch; and (c) desolventizing the solution masterbatch to form a polymer-filler composite.

Abstract: Systems and methods for managing the waste associated with the extraction of rubber from guayule shrubs are provided. Also provided is a portable local sub-station for reducing the transportation costs associated with the processing of guayule shrubs for the extraction of rubber. Use of the disclosed systems, methods and/or local sub-station can reduce transportation costs, reduce processing costs and reduce the downstream processing complexity associated with the extraction of rubber from guayule shrubs.

Abstract: Provided herein are organic solvent-based processes for the removal of rubber from non-Hevea plants such as guayule shrubs. By the use of the processes, solid purified rubber can be obtained that contains 0.05-0.5 weight % dirt, 0.2-1.5 weight % ash, and 0.1-4 weight % resin (when it has been dried so as to contain 0.8 weight % volatile matter).

Abstract: Provided herein are organic solvent-based processes for the removal of rubber from non-Hevea plants such as guayule shrubs. By the use of the processes, solid purified rubber can be obtained that contains 0.05-0.5 weight % dirt, 0.2-1.5 weight % ash, and 0.1-4 weight % resin (when it has been dried so as to contain 0.8 weight % volatile matter).

Abstract: An air spring bellow formed from a rubber composition including a rubber component that contains a polyisoprene rubber and syndiotactic 1,2-polybutadiene. The syndiotactic 1,2-polybutadiene has a low crystallinity of 40 percent or less and the rubber composition includes a filler.

Abstract: Provided herein are organic solvent-based processes for the removal of rubber from non-Hevea plants such as guayule shrubs. By the use of the processes, solid purified rubber can be obtained that contains 0.05-0.5 weight % dirt, 0.2-1.5 weight % ash, and 0.1-4 weight % resin (when it has been dried so as to contain 0.8 weight % volatile matter).

Abstract: Provided herein is a fractionator and related process for separating solubilized rubber from a co-solvent based miscella.

Abstract: Systems and methods for managing the waste associated with the extraction of rubber from guayule shrubs are provided. Also provided is a portable local sub-station for reducing the transportation costs associated with the processing of guayule shrubs for the extraction of rubber. Use of the disclosed systems, methods and/or local sub-station can reduce transportation costs, reduce processing costs and reduce the downstream processing complexity associated with the extraction of rubber from guayule shrubs.

Abstract: Systems and methods for managing the waste associated with the extraction of rubber from guayule shrubs are provided. Also provided is a portable local sub-station for reducing the transportation costs associated with the processing of guayule shrubs for the extraction of rubber. Use of the disclosed systems, methods and/or local sub-station can reduce transportation costs, reduce processing costs and reduce the downstream processing complexity associated with the extraction of rubber from guayule shrubs.

Abstract: Provided herein are cured rubber compositions containing guayule natural rubber with 2.5-4 weight % resin and fillers. By the use of a specified cure package that contains increased amounts of sulfur and accelerator, the cured rubber compositions are found to exhibit strain induced crystallization (as can be observed by X-ray diffraction). Also provided are related methods for preparing the rubber compositions.

Abstract: Provided herein are organic solvent-based processes for the removal of rubber from aged briquettes made from compressed plant matter (briquettes) of non-Hevea plants.

Abstract: Provided herein are cured rubber compositions containing guayule natural rubber with 2.5-4 weight % resin and fillers. By the use of a specified cure package that contains increased amounts of sulfur and accelerator, the cured rubber compositions are found to exhibit strain induced crystallization (as can be observed by X-ray diffraction). Also provided are related methods for preparing the rubber compositions.

Abstract: Methods are described for quantifying an amount of natural rubber in a plant from a sample of the plant by obtaining a NMR spectrum and analyzing the signal peaks for the natural rubber in the plant sample and a standard component tested in combination with the plant sample. The NMR testing is conducted on a liquid state sample of a solution containing dissolved plant sample and standard component. A pre-determined and known amount of standard component is present in the liquid state sample and provides a reference for calculating an estimated amount of natural rubber in the plant sample. The estimated amount of natural rubber in the sample can be used to quantify the amount of extractable rubber in the sampled plant.

Abstract: Provided herein is a fractionator and related process for separating solubilized rubber from a co-solvent based miscella.

Abstract: Provided herein are methods for the removal of organic solvents from wet bagasse. The use of the methods result in dried bagasse that contains no more than 1 weight percent organic solvents.

Abstract: Provided herein are organic solvent-based processes for the removal of rubber from non-Hevea plants such as guayule shrubs. By the use of the processes, solid purified rubber can be obtained that contains 0.05-0.5 weight % dirt, 0.2-1.5 weight % ash, and 0.1-4 weight % resin (when it has been dried so as to contain 0.8 weight % volatile matter).

Abstract: Provided herein are methods for the removal of organic solvents from wet bagasse. The use of the methods result in dried bagasse that contains no more than 1 weight percent organic solvents.

Abstract: Provided herein are organic solvent-based processes for the removal of rubber from non-Hevea plants such as guayule shrubs. By the use of the processes, solid purified rubber can be obtained that contains 0.05-0.5 weight % dirt, 0.2-1.5 weight % ash, and 0.1-4 weight % resin (when it has been dried so as to contain 0.8 weight % volatile matter).