Abstract: This application discloses a device discovery method, a device, and a system, and relates to the field of communication technologies, to guarantee reliability of device discovery, reduce network overheads, and reduce network load. In this application, a discovery device (for example, a first device) discovers a device by multicasting/broadcasting a discovery request message. When receiving the discovery request message and determining that there is another device (for example, a third device) that meets a condition specified by the first device, a device (for example, a second device) may notify the first device.

Abstract: Provide is an animal model of a chimeric antigen receptor (CAR)-T cell therapy for leukemia complicated by cytokine release syndrome (CRS), and a preparation method and use thereof. The preparation method of an animal model of a CD19 CAR-T cell therapy for leukemia complicated by CRS includes: preparing a CD19 CAR-T cell line: conducting cell separation of peripheral blood mononuclear cells (PBMCs), magnetic beads cell sorting of T cells, activation of the T cells, lentiviral infection, and amplification of CD19 CAR-T cells; and constructing CRS animal models after high-dose and low-dose CD19 CAR-T infusions: implanting a Nalm-6 cell line into a living animal to allow leukemia tumor burden to obtain a leukemia tumor-burdened living animal, and injecting the CD19 CAR-T cell line into the leukemia tumor-burdened living animal. The present disclosure further provides new use of the animal model of a CD19 CAR-T cell therapy for leukemia complicated by CRS.

Abstract: A light emitter that operates through a display may cause display artifacts, even when the light emitter operates using non-visible wavelengths. Display artifacts caused by a light emitter that operates through a display may be referred to as emitter artifacts. To mitigate emitter artifacts, operating conditions for a display frame may be used to determine an optimal firing time for the light emitter during that display frame. The operating conditions used to determine the optimal firing time may include emitter operating conditions, display content statistics, display brightness, temperature, and refresh rate. Operating conditions from one or more previous frames may be stored in a frame buffer and may be used to help determine the optimal firing time for the light emitter during a display frame. Pixel values for the display may be modified to mitigate emitter artifacts.

Abstract: An electronic device may include a display. Control circuitry may operate the display at different frame rates such as 60 Hz, 80 Hz, and 120 Hz. The control circuitry may determine which frame rate to use based on a speed of animation on the display and based on a type of animation on the display. To mitigate the appearance of judder as the display frame rate changes, the control circuitry may implement techniques such as hysteresis (e.g., windows of tolerance around speed thresholds to ensure that the display frame rate does not change too frequently as a result of noise), speed thresholds that are based on a user perception study, consistent latency between touch input detection and corresponding display output across different frame rates (e.g., using a fixed touch scan rate that is independent of frame duration), and animation-specific speed thresholds for triggering frame rate changes.

Abstract: An electrolyte infiltration method and apparatus for a pouch cell, and an electrolyte injection machine are provided. The electrolyte infiltration method for the pouch cell includes: S1, a cell assembly after electrolyte injection is placed in a closed environment, and a cell gas pocket is in an open state; S2, the closed environment is disposed to a first vacuum value, and then an opening of the cell gas pocket is sealed; S3, the closed environment is set to a second vacuum value, a pressure is maintained, and the second vacuum value is lower than the first vacuum value; S4, the closed environment is set to be a normal pressure, and the pressure is maintained; S5, S3 and S4 are repeated, and the opening of the cell gas pocket is opened; and S6, the closed environment is set to a third vacuum value, and the cell gas pocket is sealed.

Abstract: The invention discloses a blockchain-based intrusion detection system for railway signal, which is built on a blockchain's distributed chain structure, without a central, trusted control center. This design mitigates the vulnerabilities associated with centralized intrusion detection centers. Additionally, by utilizing a blockchain-based distributed structure, it also eliminates the risk of a single point of failure for the intrusion detection center. Moreover, the data within the blockchain-based intrusion detection system is highly resistant to malicious tampering. This is achieved by leveraging the consensus mechanism inherent in the blockchain, which can achieve consensus among intrusion detection nodes. The current invention solves the internal evil attacks and avoid the inability to reach consensus between nodes due to internal evil, thereby affecting the intrusion detection performance; at the same time, the intrusion detection model can resist external network attacks.

Abstract: An ultrasonic image quality quantitative evaluation method includes segmenting a focus area aiming at a target ultrasonic image to extract a region of interest and perform a masking operation to acquire an image segmentation result mask; taking the image segmentation result mask as a reference image, and quantitatively comparing the reference image with a corresponding focus area according to a set evaluation standard to acquire a plurality of evaluation result indexes; and inputting the plurality of evaluation result indexes as an image feature into a classifier to acquire a quality quantification result of the focus area of the target ultrasonic image, where the classifier takes the plurality of evaluation result indexes corresponding to a sample image as an input feature, takes an image quality label of the labeled focus area as an output, and acquires the quality quantification result through training based on a set loss function.

Abstract: The invention discloses a blockchain-based intrusion detection system for railway signal, which is built on a blockchain's distributed chain structure, without a central, trusted control center. This design mitigates the vulnerabilities associated with centralized intrusion detection centers. Additionally, by utilizing a blockchain-based distributed structure, it also eliminates the risk of a single point of failure for the intrusion detection center. Moreover, the data within the blockchain-based intrusion detection system is highly resistant to malicious tampering. This is achieved by leveraging the consensus mechanism inherent in the blockchain, which can achieve consensus among intrusion detection nodes. The current invention solves the internal evil attacks and avoid the inability to reach consensus between nodes due to internal evil, thereby affecting the intrusion detection performance; at the same time, the intrusion detection model can resist external network attacks.

Abstract: Provides are a drive method of a display panel and a display apparatus. The drive method of the display panel includes: obtaining a current temperature of the display panel; obtaining a current overdrive lookup table corresponding to the current temperature according to the current temperature and initial overdrive lookup tables corresponding to prestored set temperatures, wherein the initial overdrive lookup tables include a plurality of different first gray-scale values, a plurality of different second gray-scale values and initial gray-scale values corresponding to any first gray-scale value and any second gray-scale value, and the current overdrive lookup table includes a plurality of different first gray-scale values, a plurality of different second gray-scale values and current gray-scale values corresponding to any first gray-scale value and any second gray-scale value; and driving sub-pixels in the display panel to charge corresponding data voltages according to the current overdrive lookup table.

Abstract: The present disclosure discloses IL-2 mutants and uses thereof. More specifically, the disclosure provides IL-2 mutants and corresponding fusion proteins, conjugates, nucleic acid fragments, vectors, host cells, methods for preparing the mutants or fusion proteins, IL-2 mutants or fusion proteins prepared according to the methods, pharmaceutical compositions, pharmaceutical uses, methods for treating diseases, and methods for preferentially stimulating regulatory T cells. Compared to wild-type IL-2, the IL-2 mutants of the present disclosure have higher Tm values and improved stability; alternatively, the IL-2 mutants of the present disclosure have an increased yield or changed binding activity to the IL-2R?? complexes compared to wild-type IL-2.

Abstract: The present disclosure discloses IL-2 mutants and uses thereof. More specifically, the disclosure provides IL-2 mutants and corresponding fusion proteins, conjugates, nucleic acid fragments, vectors, host cells, methods for preparing the mutants or fusion proteins, IL-2 mutants or fusion proteins prepared according to the methods, pharmaceutical compositions, pharmaceutical uses, methods for treating diseases, and methods for preferentially stimulating regulatory T cells. Compared to wild-type IL-2, the IL-2 mutants of the present disclosure have higher Tm values and improved stability; alternatively, the IL-2 mutants of the present disclosure have an increased yield or changed binding activity to the IL-2R?? complexes compared to wild-type IL-2.

Abstract: Provided are a murine or fully human monoclonal antibody targeting SEMA4D and a preparation method therefor, wherein the antibody binds to the SEMA4D antigen and has activities such as combating tumors.

Abstract: The present invention discloses a method for constructing and optimizing a molecular structure model of lignite, comprising: collecting and processing a lignite sample, analyzing a lignite experimental sample, calculating the number of carbon atoms in lignite and the number of carbon atoms in other parameters, obtaining the sizes of aromatic clusters, and determining the composition features and number of aromatic structural units in lignite; calculating the total number of carbon atoms and the number of aliphatic carbon atoms in lignite; obtaining the categories and number of oxygen-containing functional groups in lignite based on the contents of aromatic hydrocarbon, aliphatic hydrocarbon and various oxygen-containing functional groups, and designing the structural forms of nitrogen and sulfur; constructing a molecular structure model of lignite.

Abstract: The present disclosure discloses IL-2 mutants and uses thereof. More specifically, the disclosure provides IL-2 mutants and corresponding fusion proteins, conjugates, nucleic acid fragments, vectors, host cells, methods for preparing the mutants or fusion proteins, IL-2 mutants or fusion proteins prepared according to the methods, pharmaceutical compositions, pharmaceutical uses, methods for treating diseases, and methods for preferentially stimulating regulatory T cells. Compared to wild-type IL-2, the IL-2 mutants of the present disclosure have higher Tm values and improved stability; alternatively, the IL-2 mutants of the present disclosure have an increased yield or changed binding activity to the IL-2R?? complexes compared to wild-type IL-2.

Abstract: Disclosed herein are chimeric blastocysts, such as chimeric blastocysts derived from a host blastocyst from a first mammalian species and having donor pluripotent stem cells from a second mammalian species, wherein the donor pluripotent stem cells have reduced expression or reduced biological activity of one or more proteins in the TLR/NF-kB signaling pathway or the p53 pathway. Methods of preparing chimeric blastocysts and methods of obtaining mammalian organs and tissues are also provided.

Abstract: Provided are a murine or fully human monoclonal antibody targeting SEMA4D and a preparation method therefor, wherein the antibody binds to the SEMA4D antigen and has activities such as combating tumors.

Abstract: A BLyS antibody, preparation method therefor and application thereof, the BLyS antibody comprising one or more of CDR1, CDR2 and CDR3 of a heavy chain variable region of the BLyS antibody, and/or one or more of CDR1, CDR2 and CDR3 of a light chain variable region of the BLyS antibody. An amino acid sequence of the antibody is shown in a sequence listing. The BLyS antibody has a high affinity, and may observably and effectively seal a BLyS protein at a protein level and a cell level, and prevent the BLyS protein from binding to a receptor. The BLyS antibody lacks a cross-reaction with homologous protein antigens such as human APRIL, and enjoys good biological activity. The BLyS antibody may inhibit the proliferation of human BLyS-induced mouse B cells and may therefore be used for preparing a drug for preventing or treating diseases associated with BLyS expression or dysfunction.