Patents by Inventor Yinhua He

Yinhua He has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Crystalline polymorphs of benfotiamine, process for preparation and its use thereof
    Patent number: 9718846
    Abstract: The present invention is directed to crystalline polymorphs of benfotiamine, its methods of preparation and its use thereof. Five crystalline polymorphs of benfotiamine are designated as crystalline forms A, B, C, D and E, and may be distinguished by their respective patterns of X-ray powder diffraction (XRPD), differential scanning calorimetry (DSC), infrared spectroscopy (IR), raman spectroscopy, moreover by their diverse preparing process. The crystalline polymorphs of the present invention are useful as they act in treating Vitamin B1 deficiency, metabolic disorders, mental illness and disorders, diabetes complications, neurodegerative diseases. Further the present invention is a process for preparing and transforming diverse crystalline form of benfotiamine through different synthesis routes and varied solvents and combinations. The crystalline polymorphs of the present invention are basically pure.
    Type: Grant
    Filed: October 31, 2012
    Date of Patent: August 1, 2017
    Assignee: Shanghai Ri Xin Biotechnology Co., Ltd.
    Inventors: Chunjiu Zhong, Yinhua He, Xuefeng Mei, Huan Zhang
  • Crystalline polymorphs of benfotiamine, process for preparation and its use thereof
    Patent number: RE49935
    Abstract: The present invention is directed to crystalline polymorphs of benfotiamine, its methods of preparation and its use thereof. Five crystalline polymorphs of benfotiamine are designated as crystalline forms A, B, C, D and E, and may be distinguished by their respective patterns of X-ray powder diffraction (XRPD), differential scanning calorimetry (DSC), infrared spectroscopy (IR), raman spectroscopy, moreover by their diverse preparing process. The crystalline polymorphs of the present invention are useful as they act in treating Vitamin B1 deficiency, metabolic disorders, mental illness and disorders, diabetes complications, neurodegerative diseases. Further the present invention is a process for preparing and transforming diverse crystalline form of benfotiamine through different synthesis routes and varied solvents and combinations. The crystalline polymorphs of the present invention are basically pure.
    Type: Grant
    Filed: February 7, 2022
    Date of Patent: April 23, 2024
    Assignee: SHANGHAI RAISING PHARMACEUTICAL CO., LTD.
    Inventors: Chunjiu Zhong, Yinhua He, Xuefeng Mei, Huan Zhang