Abstract: Provided are a class of compounds, a stereoisomer, an optical isomer, a pharmaceutically acceptable salt, a prodrug, a solvate (for example, a hydrate) or an isotope derivative thereof. The compounds have a tri-heterocyclic structure (for example, the structure represented by formula (A)), which is a novel structure, thereby providing a new direction for the development of SOS1 inhibitor drugs. In-vitro enzyme activity inhibition activity studies show that the compounds have a relatively strong inhibition effect on SOS1 and can be used as a prospective compound for preventing and/or treating SOS1-mediated diseases. Moreover, said compounds also exhibit significant inhibitory activity on NCI-H358 cell proliferation. Furthermore, a specific synthesis method is provided. The synthesis method is simple in process, convenient to operate and beneficial to large-scale industrial production and use.

Abstract: The present disclosure discloses a grounding wire detection circuit, for monitoring whether an electrical device is grounded in real time, the grounding wire detection circuit including: a grounding detection circuit and a sampling control circuit, wherein the grounding detection circuit is electrically connected to a live wire, a neutral wire and a grounding wire of a single-phase three-wire type input, the live wire and the neutral wire are electrically connected to a main circuit of the electrical device; and the sampling control circuit is configured to isolate a current detected by the grounding detection circuit and convert the current into a sampling voltage. The real-time monitoring of whether or not a device is grounded may be achieved by detecting the sampling voltage, so as to alarm, cut off electrical device accordingly, which can improve safety of using the electrical device.

Abstract: The present disclosure discloses a grounding wire detection circuit, for monitoring whether an electrical device is grounded in real time, the grounding wire detection circuit including: a grounding detection circuit and a sampling control circuit, wherein the grounding detection circuit is electrically connected to a live wire, a neutral wire and a grounding wire of a single-phase three-wire type input, the live wire and the neutral wire are electrically connected to a main circuit of the electrical device; and the sampling control circuit is configured to isolate a current detected by the grounding detection circuit and convert the current into a sampling voltage. The real-time monitoring of whether or not a device is grounded may be achieved by detecting the sampling voltage, so as to alarm, cut off electrical device accordingly, which can improve safety of using the electrical device.

Abstract: A system and a method for classifying text messages, such as social media messages into sentiment valence categories are provided. The system comprising a module for decomposing text messages, a module for cleaning text messages, a module for producing feature data of text messages, and a module for classifying text messages into sentiment valence categories. The module for decomposing text messages is configured to: receive a text message, parse the text message into separate portions in response to parsing criteria based on sentence delimiters, wherein the separate portions are sentences, phrases and words, and rejoin at least some of the separate portions of the text message into sentences in response to predefined linguistic conditions.

Abstract: There is provided a computer system for negotiating a sale. A computer system comprises a processor adapted to execute stored instructions and a memory device that stores instructions for execution by the processor. The memory device comprises computer-implemented code adapted to make an offer to sell in a round of a negotiation. The memory device also comprises computer-implemented code adapted to receive a counter-offer. The memory device additionally comprises computer-implemented code adapted to determine whether to accept the counter-offer based on a pre-determined target, a best alternative to a negotiated agreement (BATNA), and the round of the negotiation.