Patents by Inventor Yiping Rong
Yiping Rong has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240269276Abstract: The present invention relates to a specific binding protein targeting PD-L1 and CD73, wherein the specific binding protein is capable of specifically binding to PD-L1 and/or a fragment thereof, and CD73 and/or a fragment thereof. The present invention further relates to use of the specific binding protein in the treatment, prevention and/or diagnosis of diseases such as immune diseases, acute and chronic inflammatory diseases, and tumor diseases.Type: ApplicationFiled: May 24, 2022Publication date: August 15, 2024Inventors: Qianqian Shan, Xuekun Zhang, Xin Gan, Haishan Luo, Lei Shi, Yongqiang Wang, Xingxing Jia, Rongchao Wang, Yiping Rong
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Publication number: 20240228635Abstract: Involved is an isolated antigen binding protein, being capable of binding CCR8 derived from a primate animal. Further involved are a pharmaceutical composition comprising the antigen binding protein, and an application of the antigen binding protein and/or the pharmaceutical composition in the prevention and/or treatment of a tumor or a cancer.Type: ApplicationFiled: August 27, 2021Publication date: July 11, 2024Applicant: B7 THERAPEUTICS INC.Inventors: Shuang LU, Yongqiang WANG, Xin GAN, Fei CHEN, Jinqiu HE, Xiaohui SHAO, Shaoping HU, Chuchu ZHAO, Jiuqiao ZHAO, Yiping RONG
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Publication number: 20240132603Abstract: Involved is an isolated antigen binding protein, being capable of binding CCR8 derived from a primate animal. Further involved are a pharmaceutical composition comprising the antigen binding protein, and an application of the antigen binding protein and/or the pharmaceutical composition in the prevention and/or treatment of a tumor or a cancer.Type: ApplicationFiled: August 26, 2021Publication date: April 25, 2024Applicant: HARBOUR BIOMED US, INC.Inventors: Shuang LU, Yongqiang WANG, Xin GAN, Fei CHEN, Jinqiu HE, Xiaohui SHAO, Shaoping HU, Chuchu ZHAO, Jiuqiao ZHAO, Yiping RONG
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Publication number: 20240067748Abstract: An isolated monoclonal antibody capable of specifically binding to Trop2 is provided, together with a nucleic acid molecule encoding the antibody, as well as an expression vector, a host cell, and a method for expressing the antibody. An immunoconjugate, a bispecific molecule, a chimeric antigen receptor, an oncolytic virus, and a pharmaceutical composition containing the antibody, and a diagnostic or therapeutic method using the antibody are also provided.Type: ApplicationFiled: December 28, 2021Publication date: February 29, 2024Inventors: Qiang LV, Bing HUANG, Yiping RONG
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Publication number: 20230357425Abstract: Provided an isolated antigen binding protein having one or more of the following properties: a. capable of binding to both human CD73 and Cynomolgus monkey CD73; b. capable of inhibiting 5?ectonucleotidase activity of CD73; c. capable of mediating CD73 internalization; d. capable of promoting T cell proliferation; e. with a relatively stable concentration in serum; and f. capable of inhibiting tumor growth and/or tumor cell proliferation. In addition, provided a method for producing the isolated antigen binding protein as well as pharmaceutical uses of the isolated antigen binding protein in preventing, alleviating and/or treating tumor.Type: ApplicationFiled: August 20, 2020Publication date: November 9, 2023Applicant: Harbour BioMed (Shanghai) Co., LtdInventors: Lei SHI, Xin GAN, Qianqian SHAN, Yiping RONG, Yun HE
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Publication number: 20230312722Abstract: Provided are a B7H4-targeting antibody or a variant thereof, and a bispecific antibody containing the B7H4-targeting antibody, wherein the B7H4-targeting antibody comprises a light chain variable region and a heavy chain variable region. The variant has an amino acid mutation in the light chain variable region or heavy chain variable region of the antibody and can maintain the function of the antibody. The B7H4-targeting antibody has the activity of binding to human B7H4 and cynomolgus macaque B7H4, and does not cross-react with other B7 family members. The B7H4-targeting antibody exhibits good anti-tumor activity, T-cell activation activity and internalization activity in in-vivo and in-vitro experiments, and is more suitable for use as an ADC drug. Further provided is a bispecific antibody targeting B7H4 and CD3, which has a longer half-life, retains good stability and hydrophilicity, and reduces toxicity while ensuring efficacy.Type: ApplicationFiled: June 29, 2021Publication date: October 5, 2023Applicant: NONA BIOSCIENCES (SUZHOU) CO., LTD.Inventors: Xiaodong WU, Yongqiang WANG, Fei CHEN, Jinqiu HE, Gezi JIA, Chuchu ZHAO, Qingfang CHEN, Yiping RONG
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Publication number: 20230303698Abstract: The present invention provides a binding protein and use thereof, wherein the binding protein comprises a first protein functional region binding to a targeting moiety of an antigen on a target cell, and a second protein functional region binding to an effector moiety of an antigen on an immune effector cell; and the binding protein is selected from the following structure: the first protein functional region is of a Fab structure, the second protein functional region is of a VH structure or a Fab structure, and the first protein functional region and the second protein functional region are arranged sequentially from the N-terminus to the C-terminus of the binding protein. The binding protein can bring the immune effector cell and the specific target cell together, efficiently and selectively activate the immune effector cell in a microenvironment of the specific target cell, further enhance immune responses, and reduce toxic and side effects caused by non-specific activation of peripheral immune cells.Type: ApplicationFiled: June 29, 2021Publication date: September 28, 2023Inventors: Yun HE, Lei SHI, Xiaodong WU, Chen ZHONG, Bing HUANG, Yiping RONG
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Publication number: 20230235090Abstract: Provided are a bispecific antibody and use thereof. The bispecific antibody comprises a B7-H4-targeting antigen-binding domain and a 4-1BB-targeting antigen-binding domain. The bispecific antibody has one or two or three sites for binding to 4-1BB, along with a novel fully human B7-H4 antibody. The bispecific antibody specifically binds to tumor cells by targeting B7-H4, reducing toxicity induced by 4-1BB activation. In addition, the bispecific antibody of the present invention comprises a human Fc fragment, and thus retains the binding of Fc to FcRn and has a longer half-life.Type: ApplicationFiled: June 29, 2021Publication date: July 27, 2023Applicant: HARBOUR BIOMED US, INC.Inventors: Lei SHI, Chen ZHONG, Xiaodong WU, Yun HE, Fei CHEN, Xiaocheng LV, Jinli XIE, Yiping RONG, Bing HUANG, Fangfang DU, Jianxun ZHAO
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Publication number: 20220411513Abstract: Provided is an anti-PD-L1 antigen binding protein, capable of binding to primate-derived PD-L1 with a KD value of 1×10?8 M or less. The antigen binding protein can block the binding of PD-1 and CD80 to PD-L1, stimulate the secretion of cytokines in immune cells, and can inhibit tumor growth and/or tumor cell proliferation. Also provided is a fusion protein, comprising human TGFBRII or a fragment thereof and the antigen binding protein. Also provided is an application of the antigen binding protein and/or the fusion protein in the prevention and treatment of tumors or cancers.Type: ApplicationFiled: September 29, 2020Publication date: December 29, 2022Applicant: Harbour BioMed (Shanghai) Co., LtdInventors: Yun HE, Shuwen REN, Bin LIU, Xin GAN, Donghai LI, Fei CHEN, Ling WANG, Jin LI, Yiping RONG
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Publication number: 20220363781Abstract: Related are an anti-TSLP antibody or an antigen-binding fragment thereof, nucleic acid molecules coding the same, and a method for preparing the same. The anti-TSLP antibody or the antigen-binding fragment thereof have high affinity to TSLP, capable of effectively binding with TSLP and blocking the proliferative effect of TSLP with respect to Ba/F3-hTSLPR-hIL7R? cells, and blocking the capability of TSLP in activating and secreting cytokines with respect to PBMC. At the same time, further related are a medicinal composition comprising the antibody or the antigen-binding fragment thereof, and uses of the composition in preparing a medicament for preventing and/or treating asthma, allergic inflammation, an allergic reaction or autoimmune disease.Type: ApplicationFiled: December 8, 2020Publication date: November 17, 2022Applicants: SICHUAN KELUN-BIOTECH BIOPHARMACEUTICAL CO., LTD., Harbour Biomed (Suzhou) Co., Ltd.Inventors: Liang XIAO, Jinqiu HE, Tongtong XUE, Hongshui LIU, Jingyi WANG, Hongzhuan GU, Shuntao LUO, Yiping RONG, Dengnian LIU, Yun HE
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Publication number: 20220340673Abstract: Provided are an antibody targeting BCMA, a bispecific antibody targeting BCMA and CD3, and applications thereof. The antibody targeting BCMA comprises two heavy chain variable regions, the heavy chain variable regions comprising HCDR1, HCDR2, and HCDR3 as shown in the amino acid sequences of SEQ ID NO: 22, SEQ ID NO: 33 and SEQ ID NO: 42, or HCDR1, HCDR2, and HCDR3 as shown in the amino acid sequences of SEQ ID NO: 26, SEQ ID NO: 37 and SEQ ID NO: 41. The antibody effectively targets human BCMA and binds to cynomolgus BCMA; the bispecific antibody effectively targets both human BCMA and human CD3, and can bind to cynomolgus BCMA and cynomolgus CD3.Type: ApplicationFiled: September 29, 2020Publication date: October 27, 2022Inventors: Lei SHI, Xuekun ZHANG, Yun HE, Jianxun ZHAO, Wei ZHOU, Fei CHEN, Xiangyang TAN, Yiping RONG
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Publication number: 20220002414Abstract: Disclosed are isolated monoclonal antibodies, comprising a CD152-binding domain, wherein the antibodies bind specifically to human CD152. Methods of making and using the antibodies to treat diseases including cancers and autoimmune diseases are also provided.Type: ApplicationFiled: July 14, 2021Publication date: January 6, 2022Applicant: Harbour BioMed (Shanghai) Co., Ltd.Inventors: Xin GAN, Yun HE, Yuqiang SHEN, Jiuqiao ZHAO, Yiping RONG, Frank Grosveld, Dubravka Drabek, Marinus (Rien) Van Haperen, Rick Janssens
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Patent number: 11098122Abstract: Disclosed are isolated monoclonal antibodies, comprising a CD152-binding domain, wherein the antibodies bind specifically to human CD152. Methods of making and using the antibodies to treat diseases including cancers and autoimmune diseases are also provided.Type: GrantFiled: December 19, 2018Date of Patent: August 24, 2021Assignee: HARBOUR BIOMED (SHANGHAI) CO., LTD.Inventors: Xin Gan, Yun He, Yuqiang Shen, Jiuqiao Zhao, Yiping Rong, Frank Grosveld, Dubravka Drabek, Marinus (Rien) Van Haperen, Rick Janssens
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Publication number: 20190202914Abstract: Disclosed are isolated monoclonal antibodies, comprising a CD152-binding domain, wherein the antibodies bind specifically to human CD152. Methods of making and using the antibodies to treat diseases including cancers and autoimmune diseases are also provided.Type: ApplicationFiled: December 19, 2018Publication date: July 4, 2019Inventors: Xin GAN, Yun HE, Yuqiang SHEN, Jiuqiao ZHAO, Yiping RONG
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Patent number: 10058588Abstract: A protease resistant polypeptide includes an amino acid sequence that has a sequence identity at least 80% homologous to about 10 to 80 consecutive amino acids of SEQ ID NO:1.Type: GrantFiled: May 23, 2017Date of Patent: August 28, 2018Assignee: Case Western Reserve UniversityInventors: Clark Distelhorst, Yiping Rong
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Publication number: 20180161391Abstract: A protease resistant polypeptide includes an amino acid sequence that has a sequence identity at least 80% homologous to about 10 to 80 consecutive amino acids of SEQ ID NO:1.Type: ApplicationFiled: May 23, 2017Publication date: June 14, 2018Inventors: Clark Distelhorst, Yiping Rong
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Patent number: 9657073Abstract: A protease resistant polypeptide includes an amino acid sequence that has a sequence identity at least 80% homologous to about 10 to 80 consecutive amino acids of SEQ ID NO:1.Type: GrantFiled: September 1, 2011Date of Patent: May 23, 2017Assignee: Case Western Reserve UniversityInventors: Clark Distelhorst, Yiping Rong
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Publication number: 20130217633Abstract: A protease resistant polypeptide includes an amino acid sequence that has a sequence identity at least 80% homologous to about 10 to 80 consecutive amino acids of SEQ ID NO:1.Type: ApplicationFiled: September 1, 2011Publication date: August 22, 2013Applicant: CASE WESTERN RESERVE UNIVERSITYInventors: Clark Distelhorst, Yiping Rong
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Patent number: 8445441Abstract: A purified polypeptide for inhibiting binding of BCL-2 to IP3 receptors includes an amino acid sequence consisting of about 10 to 80 amino acids. The amino acid sequence has a sequence identity at least 90% homologous to a portion of SEQ ID NO:1. The polypeptide inhibits binding of Bcl-2 to IP3 receptors of cells that express IP3R and Bcl-2 and induces apoptosis in a cell.Type: GrantFiled: August 26, 2011Date of Patent: May 21, 2013Assignee: Case Western Reserve UniversityInventors: Clark W. Distelhorst, Yiping Rong
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Publication number: 20110312896Abstract: A purified polypeptide includes about 5 to about 80 amino acids and includes an amino acid sequence corresponding to a portion of SEQ ID NO:1. The polypeptide inhibiting binding of Bcl-2 to IP3 receptors of cells that express IP3R and Bcl-2.Type: ApplicationFiled: August 26, 2011Publication date: December 22, 2011Inventors: Clark W. Distelhorst, Yiping Rong