Patents by Inventor Yiping Zhang

Yiping Zhang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20210130838
    Abstract: A non-naturally occurring heterologous CRISPR-Cas12a genomic editing system is described, including or encoding at least one Cas12a ortholog endonuclease selected from among Lb5Cas12a, CMaCas12a, BsCas12a, BoCas12a, M1Cas12a, Mb2Cas12a, MbCas12a TsCas12a, and MAD7 endonucleases. The ortholog endonucleases enable genomic editing of plants at low temperatures, e.g., below 25° C. The CRISPR-Cas12a system can be employed for targeting PAM sites such as TTN, TTV, TTTV, NTTV, TATV, TATG, TATA, YTTN, GTTA, and GTTC, utilizing corresponding gRNAs, and is readily adapted to multiplexed editing operations of plants such as rice and other food crops.
    Type: Application
    Filed: November 5, 2020
    Publication date: May 6, 2021
    Inventors: Yiping QI, Yingxiao ZHANG
  • Patent number: 10809268
    Abstract: Disclosed are methods of measuring the amount of exposure of a host to a DNA double-stranded break (DSB)-causing agent by determining the ratio of the quantity of ?-H2AX to the quantity of total H2AX in a biological sample from the host as compared to the ratio of the quantity of ?-H2AX to the quantity of total H2AX in a positive control biological sample that has been exposed to a known amount of a DSB-causing agent. Related kits and methods of quantifying DSBs in a test biological sample are also disclosed.
    Type: Grant
    Filed: February 1, 2016
    Date of Patent: October 20, 2020
    Assignee: The United States of America, as represented by the Secretary, Department of Health and Human Service
    Inventors: Christophe E. Redon, William M. Bonner, Yiping Zhang, Jiuping Ji
  • Patent number: 9889482
    Abstract: An automatic round link chain counting and cutting machine is disclosed, comprising a machine base, a first chain box and a second chain box. The machine base is provided with a control mechanism, a drive mechanism, an anti-seizing mechanism, a chain cutting mechanism, a damping guide mechanism and a detection mechanism. The control mechanism comprises a touch panel, a PLC, a relay and a control button. The drive mechanism comprises a servo motor, a reducer and a drive sprocket. The anti-seizing mechanism comprises a first guide wheel, a first rocker arm and a first secured shaft. The chain cutting mechanism comprises a press head, a press bench and a chain cutting mold. The damping guide mechanism comprises a damping plate, a first steel plate and a second steel plate. The detection mechanism comprises a second guide wheel, a second rocker arm and a second secured shaft.
    Type: Grant
    Filed: May 26, 2015
    Date of Patent: February 13, 2018
    Assignee: ZHEJIANG SHUANGNIAO MACHINERY CO., LTD.
    Inventors: Xiaming Yu, Yiping Zhang, Yuchao Qiu
  • Publication number: 20180003720
    Abstract: Disclosed are methods of measuring the amount of exposure of a host to a DNA double-stranded break (DSB)-causing agent by determining the ratio of the quantity of ?-H2AX to the quantity of total H2AX in a biological sample from the host as compared to the ratio of the quantity of ?-H2AX to the quantity of total H2AX in a positive control biological sample that has been exposed to a known amount of a DSB-causing agent. Related kits and methods of quantifying DSBs in a test biological sample are also disclosed.
    Type: Application
    Filed: February 1, 2016
    Publication date: January 4, 2018
    Applicant: The United States of America,as represented by the Secretary,Department of Health and Human Service
    Inventors: Christophe E. Redon, William M. Bonner, Yiping Zhang, Jiuping Ji
  • Publication number: 20160207096
    Abstract: An automatic round link chain counting and cutting machine is disclosed, comprising a machine base, a first chain box and a second chain box. The machine base is provided with a control mechanism, a drive mechanism, an anti-seizing mechanism, a chain cutting mechanism, a damping guide mechanism and a detection mechanism. The control mechanism comprises a touch panel, a PLC, a relay and a control button. The drive mechanism comprises a servo motor, a reducer and a drive sprocket. The anti-seizing mechanism comprises a first guide wheel, a first rocker arm and a first secured shaft. The chain cutting mechanism comprises a press head, a press bench and a chain cutting mold. The damping guide mechanism comprises a damping plate, a first steel plate and a second steel plate. The detection mechanism comprises a second guide wheel, a second rocker arm and a second secured shaft.
    Type: Application
    Filed: May 26, 2015
    Publication date: July 21, 2016
    Inventors: XIAMING YU, YIPING ZHANG, YUCHAO QIU
  • Publication number: 20070283282
    Abstract: Systems and methods are described that allow for the dynamic allocation and re-allocation of hardware and software resources to support the build, integration, and test phases of complex software development projects. The invention provides customers who have medium to large development teams, which may be geographically distributed, with an integrated development environment, which includes centralized governance of software code repositories, build systems and test systems. Embodiments of the invention include a centralized, scalable, and dynamic system architecture which allows customers to (1) replicate the internal build, integrate, and test environments that were previously used on the customer premises, (2) provision and re-provision such resources on demand, and (3) seamlessly integrate their internal environments with the system described herein.
    Type: Application
    Filed: April 18, 2007
    Publication date: December 6, 2007
    Applicant: CollabNet, Inc.
    Inventors: Nick Bonfiglio, Andrew Ryan, Yiping Zhang, Dan Mercer
  • Patent number: 5824813
    Abstract: A number of layered vanadium oxide crystalline compositions are prepared by simple hydrothermal reactions. Generally, the compositions comprise parallel layers of mixed valence vanadium oxides with guest cations intercalated between the layers. The guest cations may comprise metal coordination complexes with bidentate ligands, monomeric ammonium or diammonium cations, or mixtures of alkali metal cations with monomeric ammonium cation or diammonium cations.
    Type: Grant
    Filed: October 31, 1997
    Date of Patent: October 20, 1998
    Assignees: NEC Research Institute, Inc., Texas A&M University, Syracuse University
    Inventors: Jeffrey Robert Douglas DeBord, Robert C. Haushalter, Yiping Zhang
  • Patent number: 5717120
    Abstract: A number of layered vanadium oxide crystalline compositions are prepared by simple hydrothermal reactions. Generally, the compositions comprise parallel layers of mixed valence vanadium oxides with guest cations intercalated between the layers. The guest cations may comprise metal coordination complexes with bidentate ligands, monomeric ammonium or diammonium cations, or mixtures of alkali metal cations with monomeric ammonium cation or diammonium cations.
    Type: Grant
    Filed: October 11, 1996
    Date of Patent: February 10, 1998
    Assignees: NEC Research Institute, Inc., Syracuse University, Texas A&M University System
    Inventors: Jeffrey Robert Douglas DeBord, Robert C. Haushalter, Yiping Zhang
  • Patent number: 5659034
    Abstract: A number of layered vanadium oxide crystalline compositions are prepared by simple hydrothermal reactions. Generally, the compositions comprise parallel layers of mixed valence vanadium oxides with guest cations intercalated between the layers. The guest cations may comprise metal coordination complexes with bidentate ligands, monomeric ammonium or diammonium cations, or mixtures of alkali metal cations with monomeric ammonium cation or diammonium cations.
    Type: Grant
    Filed: June 14, 1995
    Date of Patent: August 19, 1997
    Assignee: NEC Research Institute, Inc.
    Inventors: Jeffrey Robert Douglas DeBord, Robert C. Haushalter, Yiping Zhang