Abstract: The invention discloses a type of compound that can specifically bind to ?-synuclein aggregates represented by Formula I, a radio-labelled compound thereof, a preparation method, and its use. The compound can be used as a tracer for optical imaging of ?-synuclein aggregates in biological samples or in vivo (such as the brain). After radio-labelled, the compound of the invention can be used as a radio imaging tracer for PET, SPECT, and other imaging techniques to realize the detection of ?-synuclein lesions by non-invasive visualization in vivo (such as the brain).

Abstract: A system that accommodates remapping of a state-of-charge of a rechargeable battery for different battery operating voltage ranges without repeating battery characterization testing. A first state-of-charge system can correspond to a characterization state-of-charge that is associated with a characterization operating voltage range. A second state-of-charge system can correspond to the remapped, user-defined state-of-charge that corresponds to a user-defined operating voltage range. The user-defined state-of-charge can be obtained using at least results from characterization testing based on the characterization operating voltage range, and without results from characterization testing based on the user-defined operating voltage range.

Abstract: A system and method for estimating an accumulated total battery aging over different aging patterns. A first aging pattern, first aging time, and aging model are used to determine a battery aging estimation. The aging model, battery aging estimation, and a second aging pattern are used to determine an equivalent previous aging time. By adjusting a second aging time based on the equivalent previous aging time, and applying the adjusted second aging time and second aging pattern to the aging model, a battery accumulated aging estimation is determined for the duration of the first and second aging patterns. The process can be repeated for each next aging pattern, with an equivalent previous aging time being determined for each next aging pattern and used with an associated next aging time, aging model, and next aging pattern to determine an accumulated total battery aging estimation.

Abstract: A system and method for controlling an electric machine via an inverter comprises an speed estimator that is configured to estimate a rotor speed of an electric motor to determine whether to control the inverter to operate the electric motor in a first mode or a second mode. For example, the first mode comprises a current-frequency control mode and the second mode comprises a back electromagnetic force (BEMF) mode. An electronic data processor or controller is configured to determine a first (current) command associated with a first mode of operating the electric motor, if the estimated rotor speed is a less than a speed threshold. The electronic data processor or controller is configured to determine a second (current) command associated with a second mode of operating the electric motor if the estimated rotor speed is equal to or greater than the speed threshold.

Abstract: A system and method for controlling an electric machine via an inverter comprises an speed estimator that is configured to estimate a rotor speed of an electric motor to determine whether to control the inverter to operate the electric motor in a first mode or a second mode. For example, the first mode comprises a current-frequency control mode and the second mode comprises a back electromagnetic force (BEMF) mode. An electronic data processor or controller is configured to determine a first (current) command associated with a first mode of operating the electric motor, if the estimated rotor speed is a less than a speed threshold. The electronic data processor or controller is configured to determine a second (current) command associated with a second mode of operating the electric motor if the estimated rotor speed is equal to or greater than the speed threshold.

Abstract: Systems and methods for fault detection and diagnosis in a machine. The method includes selecting fault characteristic frequencies of faults, implementing the fault characteristic frequencies as modulating signals, receiving a feedback signal from at least one sensor associated with a machine, applying active modulation using the modulating signals to the feedback signal to obtain modulated signals, and monitoring for a low-frequency fault indicative component from the modulated signals.

Abstract: An expression system, comprising: a first nucleic acid molecule having a cell-specific promoter; a second nucleic acid molecule which encodes a transcriptional activator; a third nucleic acid molecule having a first recognition sequence of the transcriptional activator; a fourth nucleic acid molecule having a first promoter and a first regulatory element; a fifth nucleic acid molecule which encodes a first regulatory protein; a sixth nucleic acid molecule having a second recognition sequence of the transcriptional activator; a seventh nucleic acid molecule having a second promoter and a second regulatory element; an eighth nucleic acid molecule which encodes a second regulatory protein; as well as a ninth nucleic acid molecule which is configured to conditionally inhibit the expression of the first regulatory protein, and a tenth nucleic acid molecule which is configured to conditionally inhibit the expression of the second regulatory protein; the first regulatory element is adapted to inhibit the function of

Abstract: Systems and methods for fault detection and diagnosis in a machine. The method includes selecting fault characteristic frequencies of faults, implementing the fault characteristic frequencies as modulating signals, receiving a feedback signal from at least one sensor associated with a machine, applying active modulation using the modulating signals to the feedback signal to obtain modulated signals, and monitoring for a low-frequency fault indicative component from the modulated signals.

Abstract: Methods and systems of optimizing efficiency of a motor drive or generator are provided. The methods include measuring data corresponding to input power and output power of a motor drive or generator at a control parameter and different load values. The methods include generating a three-dimensional surface model based on the measured data. The three-dimensional surface model can estimate an efficiency of the motor drive or generator at the control parameter and at unmeasured load values. The methods can include determining optimal efficiency of the motor drive or generator at the different load values and the unmeasured load values based on the three-dimensional surface model.

Abstract: Methods and systems of optimizing efficiency of a motor drive or generator are provided. The methods include measuring data corresponding to input power and output power of a motor drive or generator at a control parameter and different load values. The methods include generating a three-dimensional surface model based on the measured data. The three-dimensional surface model can estimate an efficiency of the motor drive or generator at the control parameter and at unmeasured load values. The methods can include determining optimal efficiency of the motor drive or generator at the different load values and the unmeasured load values based on the three-dimensional surface model.