Abstract: A manufacturing method and manufacturing device for micronutrient supplement granules involve sequentially performing physically extruding, grinding and sieving of trace elements to obtain micronutrient supplement granules having a granule size of 35-380 ?m and a granule strength greater than 10 N with a tablet press, a first grinding and granulating machine and a sieving unit including primary and secondary sieving machines. A discharge end of the tablet press is connected to a feed end of the first grinding and granulating machine, of which a discharge end is connected to a feed end of the sieving unit. Feed and discharge ends of the primary sieving machine are respectively connected to discharge end of the first grinding and granulating machine and feed end of the secondary sieving machine. The primary and secondary sieving machines have sieving meshes respectively with square and circular mesh holes.

Abstract: A compound having the structure of below Formula(I), or pharmaceutically acceptable salts thereof, are useful as Janus kinase inhibitors, wherein R1 and L1 are as herein described.

Abstract: Disclosed are a series of Janus kinase inhibitors, and particularly disclosed are a compound or pharmaceutically acceptable salts thereof of Formula (I) and use thereof in the preparation of drugs for treating Janus kinase (JAK)-related diseases.

Abstract: A method for preparing basic zinc chloride, a trace element additive, comprises 1) reacting zinc oxide with hydrochloric acid, wherein the mole ratio of zinc oxide to hydrochloric acid is 5:2, a certain amount of hydrochloric acid is previously diluted in 5-10 fold reaction water, then zinc oxide is added thereto, basic zinc chloride is produced by reacting for 1-3 hours under normal pressure condition at a temperature of 55-95 and pH of 6-8, a reaction liquid after centrifugal separation can be used as mother liquor to be recycled in next reaction, the reaction is as follows: 2HCl+5ZnO+4H2O=Zn5Cl2(OH)8·H2O; 2) water washing, centrifugal separating; 3) oven drying, pulverizing, and packing.