Abstract: The present invention provides dimethyl fumarate (DMF) particles and methods of preparing the DMF particles. Also provided is DMF coated particles comprising DMF particles coated with an enteric coating. The invention also provides various dosage forms and methods of treating a disease or disorder (e.g., multiple sclerosis).

Abstract: The present invention provides novel pharmaceutical compositions of dimethyl fumarate. The pharmaceutical compositions of the present invention comprises a first pharmaceutical bead composition and a second pharmaceutical bead composition, wherein the first pharmaceutical bead composition is an enterically coated immediate-release composition and the second pharmaceutical bead composition is an enterically coated controlled-release composition, wherein the first pharmaceutical bead composition and the second pharmaceutical bead composition both comprise dimethyl fumarate Methods of using the pharmaceutical compositions of the present invention for treating multiple sclerosis are also included.

Abstract: Provided are a smart shoe, a smart device and a method for switching functional area. The smart shoe includes a shoe body and a smart device provided on a surface of the shoe body. The smart device includes a processing unit, a locating unit, a communication unit, a solar energy receiving unit and a power supply unit. The locating unit is configured to acquire current position information of the smart shoe and send it to the processing unit. The processing unit sends the received position information to a user terminal or a remote server via the communication unit. The solar energy receiving unit is configured to receive solar energy and converting it into electrical energy which is transferred to the power supply unit. The power supply unit is connected with individual functional units of the smart device to supply the electrical energy to the smart device.

Abstract: A microgrid controller includes a database in communication with a processor. The processor is operable to receive at least one microgrid input, to determine a first plurality of optimal power characteristic levels at a corresponding one of a plurality of first time intervals for a first time period, and to determine a second plurality of optimal power characteristic levels of a device determined at a corresponding one of a plurality of second time intervals for a second time period. The first time intervals are found at a first frequency different than a second frequency of the second time intervals. One of the second plurality of optimal power characteristic level corresponds to one of the first plurality of optimal power characteristic levels at each first time interval. The processor is configured to control a device optimal power characteristic level in response to the second plurality of optimal power characteristic levels.

Abstract: The present invention provides novel pharmaceutical compositions of dimethyl fumarate. The pharmaceutical compositions of the present invention are in the form of a bead and comprise (i) an inert core; (ii) a first layer surrounding the inert core, wherein the first layer comprises dimethyl fumarate; and (iii) an enteric coating surrounding the first layer. Also provided are pharmaceutical compositions in the form of a bead comprising a core and an enteric coating surrounding the core, wherein the core comprises dimethyl fumarate. Methods of using the pharmaceutical compositions of the present invention for treating multiple sclerosis are also included.

Abstract: A microgrid according to an exemplary aspect of the present disclosure includes, among other things, a plurality of intelligent electronic devices configured to communicate directly with one another in a first language. Each of the intelligent electronic devices includes a controller and a gateway. The gateway is configured to convert incoming messages from the first language to a second language native to the controller. The first language is different than the second language. A method is also disclosed.

Abstract: A system and method for debris particle detection with adaptive learning are provided. The method includes receiving oil debris monitoring (ODM) sensor data from an oil debris monitor sensor and fleet data from a database, detecting a feature in the ODM sensor data, generating an anomaly detection signal based on detecting an anomaly by comparing the feature in the ODM sensor data to a limit defined by system information stored in the fleet data, selecting a maintenance action request based on the anomaly detection signal, and adjusting one or more of the feature, the anomaly, the limit, and the maintenance action request by applying an adaptive learning algorithm that uses the ODM sensor data, fleet data, and feedback from field maintenance of one or more engines that evolves over time.

Abstract: A method of detecting debris within a lubricant stream, the method includes generating data indicative of debris and sensor system functionality within a lubricant stream with a sensor system. The data is communicated to a controller. Features calculated from the data are indicative of a debris within the lubricant stream. The calculated features are compiled over time during operation. The compiled features are classified. An oil debris monitoring system for a turbine engine is also disclosed.

Abstract: A system for sensing data in an aircraft, includes a plurality of wireless sensors, a receiver to sample a random subset of the plurality of wireless sensors at each of a plurality of times to generate a data matrix with a plurality of sampled entries and a plurality of missing entries, and an analysis unit to analyze the data matrix to provide a plurality of solutions corresponding to the plurality of missing entries using numerical analysis.

Abstract: A method of adjusting a rotary blade includes receiving performance data for a rotary blade, receiving an adjustment constraint for the rotary blade, defining an adjustment space for alternative adjustment solutions for the rotary blade including a plurality of alternative adjustment solutions, and calculating expected performance for one of the plurality of alternative adjustment solutions. Based on the expected performance of the one of the plurality of alternative adjustment solutions, the method determines whether to calculate expected performance for another of the plurality of alternative adjustment solutions.

Abstract: A method of adjusting a rotary blade includes receiving performance data for a rotary blade, receiving an adjustment constraint for the rotary blade, defining an adjustment space for alternative adjustment solutions for the rotary blade including a plurality of alternative adjustment solutions, and calculating expected performance for one of the plurality of alternative adjustment solutions. Based on the expected performance of the one of the plurality of alternative adjustment solutions, the method determines whether to calculate expected performance for another of the plurality of alternative adjustment solutions.

Abstract: A system computes occupancy estimates based on one or more inputs, including sensor data from one or more sensor devices, constraints on allowable occupancy levels, and one or more utility functions. An occupancy estimator organizes the sensor data, the utility functions and an occupancy estimate into an objective function and executes a constrained optimization algorithm that computes the occupancy estimate, subject to the constraints, such that the objective function is minimized. The computed occupancy estimate is provided as an output by the system to one or more control and/or monitoring systems.