Abstract: A guidance system for a near-infrared fluorescein angiography operation with a 785 nm continuous wavelength light source is provided. The guidance system includes a near infrared continuous laser emitting source, a visible light illumination source, a light collector, a light splitter connected to the light collector, a visible light filter, a near infrared filter, a color camera connected to the light splitter via the visible light filter, a near infrared camera connected to the light splitter via the near infrared filter, a terminal display, and a shell configured to contact with the body tissue of the patient. The near infrared to continuous laser emitting source and the visible light illumination source are provided on a light source support in the shell. The shell is provided therein with a viewing channel which is connected to the light collector. Both the color camera and the near infrared camera are connected to the terminal display.

Abstract: A method of managing advertisement inventory in an internet advertising system is provided. The method comprises forecasting advertisement capacity using a plurality of predefined advertisement targeting parameters arranged in a tree structure to define a plurality of buckets, wherein each bucket is associated with a combination of the predefined advertisement targeting parameters. The method further comprises matching sold advertisement data with at least one of the plurality of predefined advertisement targeting parameters in the tree structure. The method further comprises determining available advertisement inventory by the inventory management system for the at least one predefined parameter by reducing the forecasted advertisement capacity by the matched sold advertisement data. The method further comprises delivering advertisements by an ad server to display devices associated with internet users who match the combination of predefined advertising targeting parameters of at least one bucket.

Abstract: The present invention discloses a method for determining the amplitude and phase of a stratified current of an overhead wire, the method comprising the following steps: S1, determining the specification, the size and main technical parameters of a wire; S2, calculating mutual inductances between conductors within a single-phase wire and the self-inductance thereof; S3, calculating mutual inductance reactance between conductors within the single-phase wire of a three-phase system and the self-inductance reactance thereof; and S4, calculating the distribution of currents in each layer. The method takes into account the magnetic field coupling effect between conductors within a wire, so as to accurately calculate the current flowing through conductors in each layer within the wire, and accurately reflect a phase relationship between conductors in each layer.

Abstract: A system and method for extracting data from an electronic health record to provide provider and patient data similarity scoring includes: encoding a problem list for a plurality of patients with concepts from a common electronic health record ontology. In one aspect, the patients have electronic health records maintained by a plurality of providers. The system and method then may parse the concepts into a plurality of clusters or categories and determining, for each of the providers, a total number of patients that have at least one problem in a cluster or category or determining, for each patient, which of the plurality of clusters or categories correspond to at least one concept encoded in the patient's problem list. The system and method then may calculate for each pair of providers or patients, a distance between the providers or patients.

Abstract: A method of managing advertisement inventory in an internet advertising system is provided. The method comprises forecasting advertisement capacity using a plurality of predefined advertisement targeting parameters arranged in a tree structure to define a plurality of buckets, wherein each bucket is associated with a combination of the predefined advertisement targeting parameters. The method further comprises matching sold advertisement data with at least one of the plurality of predefined advertisement targeting parameters in the tree structure. The method further comprises determining available advertisement inventory by the inventory management system for the at least one predefined parameter by reducing the forecasted advertisement capacity by the matched sold advertisement data. The method further comprises delivering advertisements by an ad server to display devices associated with internet users who match the combination of predefined advertising targeting parameters of at least one bucket.

Abstract: In certain embodiments, this disclosure relates to nanoparticles for drug-delivery of cytotoxic anti-cancer compounds. In certain embodiments, the nanoparticle comprises a maytansinoid and an acetalated polysaccharide-polyethylene glycol conjugate. This disclosure also relates to methods for treatment of infection and cancer are also claimed, wherein a cytotoxic compound is en capsulated in a nanoparticle is degraded at the intended target, but otherwise stable, releasing the cytotoxic compound. Compositions comprising the nanoparticles and cytotoxic drugs are also considered.

Abstract: This disclosure relates to methods and compositions for treating cancer with platinum particles. In certain embodiments, the disclosure relates to platinum particle coated with a polysaccharide, such as a heparin or modified heparin, conjugated to a polypeptide that has affinity for a cell surface cancer marker and uses related thereto.

Abstract: A system for preventing an unauthorized user in a networked computing environment includes a client computer provided with a visual test upon a request transmitted through a network by the client computer for a service, wherein the visual test is displayed on a video display, wherein the visual test requires the performance of a predetermined action on a group of images displayed on the video display in order to gain access to the service, wherein the group of images comprises at least two images that are associated with each other.

Abstract: Systems and associated methods for targeted ad delivery are described. In one aspect, a user profile includes at least one user content category identifier and a user interest score. The user interest score is increased by an amount if the content category identifier of a requested webpage matches the at least one user content category identifier. In a further aspect, the user interest score is indicative of a level of interest of the user in a content category identified by the at least one user content category identifier. In another aspect, the user interest score can be reduced according to a long-term decay rate that slowly reduces the user interest score. In another aspect, the user interest score can also be reduced according to a short-term decay rate that rapidly reduces the user interest score.

Abstract: Systems and associated methods for targeted ad delivery are described. In one aspect, a user profile includes at least one user content category identifier and a user interest score. The user interest score is increased by an amount if the content category identifier of a requested webpage matches the at least one user content category identifier. In a further aspect, the user interest score is indicative of a level of interest of the user in a content category identified by the at least one user content category identifier. In another aspect, the user interest score can be reduced according to a long-term decay rate that slowly reduces the user interest score. In another aspect, the user interest score can also be reduced according to a short-term decay rate that rapidly reduces the user interest score.

Abstract: A method and system of generating a user profile for advertisement over a computer network is disclosed. A webpage identifier that identifies a webpage and a content category identifier that identifies a content category is generated. The webpage identifier is associated with the content category identifier if web content depicted in the webpage is relevant to the content category. A web server then receives a request for the webpage including the webpage identifier and a first user identifier from a client computer connected to the computer network. A user profile is located by determining whether the first user identifier matches a second user identifier corresponding to the user profile. The user profile includes at least one user content category identifier and a corresponding user interest score. The corresponding user interest score is increased by the predetermined amount if the content category identifier matches the user content category identifier.

Abstract: An advertisement inventory management system for internet advertising is provided. The system comprises an ad server including a delivery engine capable of delivering an advertisement to a web server for display in a webpage in response to a triggering event by an internet user. A configuration module may be provided in functional communication with the delivery engine. The configuration module may be adapted to schedule an advertisement for delivery by the delivery engine. The configuration module may also be capable of communicating the advertisement to the delivery engine according to the schedule. The advertisement management system may also include an inventory management system having a plurality of advertisement targeting parameters arranged in a tree structure.

Abstract: An advertisement delivery system for internet advertising is provided. The system comprises an ad server in functional communication with a delivery engine capable of delivering an advertisement to a web server for display in a webpage in response to a triggering event by an internet user. A configuration module may be provided in functional communication with the delivery engine. The configuration module may be adapted to schedule an advertisement for delivery by the delivery engine. The configuration module may also be capable of communicating the advertisement to the delivery engine according to the schedule. The configuration module may have a schedule of advertisements for display in a defined period of time. The advertisement delivery system also may include a means for calculating in real time internet traffic flow and means for adjusting the schedule of delivery of advertisements based upon the internet traffic flow. A method of advertisement delivery for internet advertisements is also disclosed.

Abstract: Traffic to a selected network resource, such as a Web site, is forecast using a forecasting model that is based upon a selected resolution. The resolution can be a year, month, season, week, day of the week, an annual day-long event, or any other repetitive time interval for which data can be collected. Historical traffic data for the resolution of interest is retrieved from a database, and the selected forecasting model is applied to the retrieved data to produce a forecast.

Abstract: A system for receiving advertisement supported content in a media device, including a media collector for receiving primary content and secondary content in a media device, the primary content comprising a media asset and the secondary content comprising an advertisement, a file system for organizing the primary content and the secondary content, and a player for playing the primary content and inserting the secondary content into the primary content at a time determined by the file system.

Abstract: A system for preventing an unauthorized user in a networked computing environment includes a client computer provided with a visual test upon a request transmitted through a network by the client computer for a service, wherein the visual test is displayed on a video display, wherein the visual test requires the performance of a predetermined action on a group of images displayed on the video display in order to gain access to the service, wherein the group of images comprises at least two images that are associated with each other.

Abstract: A method and system of generating a user profile for advertisement over a computer network is disclosed. A webpage identifier that identifies a webpage is generated. The webpage identifier can be a universal resource locator. A content category identifier that identifies a content category is generated. The webpage identifier is associated with the content category identifier if web content depicted in the webpage is relevant to the content category. A web server then receives a request for the webpage, the request including the webpage identifier and a first user identifier, the request being received from a client computer connected to the computer network. The webpage request can include a webpage request timestamp. A user profile is located by determining whether the first user identifier matches a second user identifier corresponding to the user profile. The user profile includes at least one user content category identifier and a corresponding user interest score.

Abstract: A system and method are diminish the use of an automated program in a networked environment. A server can provide access to a service. In addition, a software module provides a client computer with a visual test upon a request transmitted through a network by the client computer for the service. The visual test requires the client computer to perform a predetermined action on a shaped object displayed on a video display in order to gain access to the service. A validation software module receives a request from the software module for the shaped object to be displayed on the video display. Further, the validation software module randomly selects a shaped object to be transmitted to the software module. The validation software module provides the software module with the shaped object. An access software module receives an access instruction from the validation software module if the client computer passes the visual test.

Abstract: A system and method are diminish the use of an automated program in a networked environment. A server can provide access to a service. In addition, a software module provides a client computer with a visual test upon a request transmitted through a network by the client computer for the service. The visual test requires the client computer to perform a predetermined action on a shaped object displayed on a video display in order to gain access to the service. A validation software module receives a request from the software module for the shaped object to be displayed on the video display. Further, the validation software module randomly selects a shaped object to be transmitted to the software module. The validation software module provides the software module with the shaped object. An access software module receives an access instruction from the validation software module if the client computer passes the visual test.