Abstract: The compounds of the invention are antagonists of MDM2 and MDMX, with excellent specificity for MDM2 and MDMX over other proteins, and with selective binding affinity to MDMX over MDM2. The compounds can therefore regulate p53 activity and treat a variety of cancers. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

Abstract: The compounds of the invention are antagonists of MDM2 and MDMX, with excellent specificity for MDM2 and MDMX over other proteins, and with selective binding affinity to MDMX over MDM2. The compounds can therefore regulate p53 activity and treat a variety of cancers. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

Abstract: The present disclosure provides a hydrothermal geothermal development method of multilateral well closed circulation, comprises the steps of: dividing a geothermal reservoir into single layers according to geothermal reservoir geological conditions, wherein an upper single layer with a lower water temperature and a higher permeability is taken as a recharge layer, and a lower single layer with a higher water temperature is taken as a production layer; tripping a production casing, and injecting cement for well cementation; performing casing lateral windowing in a vertical hole corresponding to the recharge layer, and drilling several branch radial horizontal holes into the recharge layer; performing casing lateral windowing in the vertical hole corresponding to the production layer, and drilling several branch radial horizontal holes into the production layer; tripping a guiding pipe into the production casing of the vertical hole, with a depth thereof reaching a well section between the recharge layer and th

Abstract: An energy-gathered bundle type nesting plugging and wall reinforcing device and an application thereof in karst cave plugging. The energy-gathered bundle type nesting plugging and wall reinforcing device comprises an external slotted metal pipe (1) and an internal nesting blasting tool, wherein the slotted metal pipe (1) has spiral slits (2) or straight slits (3) cut on a pipe wall thereof; the nesting blasting tool is a mandrel (5) having a surface provided with a plurality of explosive grooves (4) in which explosives are placed; the slotted metal pipe (1) is disposed to sleeve the mandrel (5) and fixed, with a movable fit therebetween. The present invention can solve the difficulty that the plugging material cannot easily reside to form a bridge, and effectively improving the plugging success rate.

Abstract: The compounds of the invention are antagonists of MDM2 and MDMX, with excellent specificity for MDM2 and MDMX over other proteins, and with selective binding affinity to MDMX over MDM2. The compounds can therefore regulate p53 activity and treat a variety of cancers. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

Abstract: The present disclosure provides a hydrothermal geothermal development method of multilateral well closed circulation, comprises the steps of: dividing a geothermal reservoir into single layers according to geothermal reservoir geological conditions, wherein an upper single layer with a lower water temperature and a higher permeability is taken as a recharge layer, and a lower single layer with a higher water temperature is taken as a production layer; tripping a production casing, and injecting cement for well cementation; performing casing lateral windowing in a vertical hole corresponding to the recharge layer, and drilling several branch radial horizontal holes into the recharge layer; performing casing lateral windowing in the vertical hole corresponding to the production layer, and drilling several branch radial horizontal holes into the production layer; tripping a guiding pipe into the production casing of the vertical hole, with a depth thereof reaching a well section between the recharge layer and th

Abstract: The compounds of the invention are antagonists of MDM2 and MDMX, with excellent specificity for MDM2 and MDMX over other proteins, and with selective binding affinity to MDMX over MDM2. The compounds can therefore regulate p53 activity and treat a variety of cancers. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

Abstract: The compounds of the invention are antagonists of MDM2 and MDMX, with excellent specificity for MDM2 and MDMX over other proteins, and with selective binding affinity to MDMX over MDM2. The compounds can therefore regulate p53 activity and treat a variety of cancers. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

Abstract: An oral care composition comprising a stannous ion source and/or a zinc ion source; a phytic acid or a phytic acid salt or mixtures thereof; characterized in that the phytic acid or phytic acid salt has an average IPn of greater than 5.2. In a composition which comprises stannous, there is a decrease in soluble stannous whilst maintaining an equivalent efficacy to a composition comprising a higher level of soluble stannous and efficacy is observed for avoiding stain and astringency problems. When zinc ions are present, it has been surprisingly found that a decrease in soluble zinc can provide an equivalent antimicrobial efficacy to a composition comprising a greater level of soluble zinc.

Abstract: The compounds of the invention are antagonists of MDM2 and MDMX, with excellent specificity for MDM2 and MDMX over other proteins, and with selective binding affinity to MDMX over MDM2. The compounds can therefore regulate p53 activity and treat a variety of cancers. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

Abstract: The present invention provides an oral care composition, containing at least 0.5% by weight of silica agglomerates, wherein each of the silica agglomerates has: (i) an overall particle size from 200 ?m to 2000 ?m, and (ii) a crush strength from 0.1N to 5N. The silica particles that make up the silica agglomerate can have an average particle size from 1 ?m to 50 ?m. The composition can have a viscosity from 10 to 90 BKU. The present invention also provides a method of encouraging proper tooth cleaning by administering the oral care composition of the present invention to a subject's tooth surface.

Abstract: The present invention provides an oral care composition containing (a) a zinc citrate; and (b) a surface-active organophosphate compound. The present invention also relates to a method of preventing a stain from depositing on a tooth surface or other oral surfaces. The present invention further relates to a method of demonstrating stain-proof efficacy of an oral care composition, as well as a demonstration product comprising a substrate coated with hydroxyapatite.

Abstract: The present invention provides an oral care composition for encouraging proper tooth cleaning, containing particulate materials which can be breakable under a brushing action with a brushing force from 0.1N to 5N. The particulate materials can have a particle size distribution characterized by (1) a change ratio of mean particle size before and after the brushing action is at least 20%, (2) a change ratio of D90 before and after the brushing action is at least 20%, (3) at least 5% of the particulate materials have a particle size greater than 200 ?m before the brushing action, and (4) no more than 30% of the particulate materials have a particle size greater than 200 ?m after the brushing action. The oral care composition can have a viscosity ranging from 10 to 90 BKU.

Abstract: The compounds of the invention are antagonists of MDM2 and MDMX, with excellent specificity for MDM2 and MDMX over other proteins, and with selective binding affinity to MDMX over MDM2. The compounds can therefore regulate p53 activity and treat a variety of cancers. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

Abstract: An oral care composition comprising a stannous ion source and/or a zinc ion source; a phytic acid or a phytic acid salt or mixtures thereof; characterised in that the phytic acid or phytic acid salt has an average IPn of greater than 5.2. In a composition which comprises stannous, there is a decrease in soluble stannous whilst maintaining an equivalent efficacy to a composition comprising a higher level of soluble stannous and efficacy is observed for avoiding stain and astringency problems. When zinc ions are present, it has been surprisingly found that a decrease in soluble zinc can provide an equivalent antimicrobial efficacy to a composition comprising a greater level of soluble zinc.

Abstract: A multi-phase down hole injector related to a down hole tool for oilfield well drilling, has a shooting pipe, an axial hole disposed in the center of the shooting pipe, one end of the shooting pipe is connected to an ellipsoid guide, at least two housing seats sets are disposed along the shooting pipe, every housing seat set are disposed with at least two housing seats of radial symmetry, the inner ends of every housing seat is separately connected to the axial hole, every housing seat is disposed with a injection barrel by the base, and the explosive cavity is disposed between the base and the housing seat. The injected viscosity fluid can exert squeezing and shearing force to the rock to make the channel and breach smaller or eliminated.

Abstract: A magnetoresistive effect element is a compound lamination including a first anti-ferromagnetic layer, a first fixed magnetic layer, a tunnel insulation layer, a free magnetic layer, a non-magnetic metal layer, a second fixed magnetic layer, and a second anti-ferromagnetic layer such that a TMR element and a SVMR element are formed, sharing the free magnetic layer.

Abstract: The spin valve head is capable of having a secure specular effect, increasing MR-ratio and Hua and outputting a prescribed head power when the head accesses a recording medium having high surface recording density. The spin valve head comprises: a first pinned magnetic layer; a non-magnetic layer being formed on the first pinned magnetic layer; and a second pinned magnetic layer being formed on the non-magnetic layer, and is characterized by an insulating specular layer being provided between the first pinned magnetic layer and the second pinned magnetic layer.

Abstract: A magnetoresistive effect element is a compound lamination including a first anti-ferromagnetic layer, a first fixed magnetic layer, a tunnel insulation layer, a free magnetic layer, a non-magnetic metal layer, a second fixed magnetic layer, and a second anti-ferromagnetic layer such that a TMR element and a SVMR element are formed, sharing the free magnetic layer.