Patents by Inventor Yishai AVIOR

Yishai AVIOR has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS OF THERAPEUTIC PROGNOSTICATION
    Publication number: 20230094922
    Abstract: Methods of determining the suitability of a subject for treatment with a therapeutic agent are provided. Methods of providing a personalized treatment protocol based on suitability of a subject to be treated with a therapeutic agent are also provided, as are methods of treating those subjects who are suitable.
    Type: Application
    Filed: February 16, 2021
    Publication date: March 30, 2023
    Inventors: Talia COHEN SOLAL, Daphna LAIFENFELD, Erez NITZAN, Yishai AVIOR
  • Methods of Inducing Metabolic Maturation of Human Pluripotent Stem Cells-Derived Hepatocytes
    Publication number: 20210077444
    Abstract: Provided are methods of increasing metabolic maturation of an immature hepatocyte, by contacting an immature hepatocyte which expresses alpha-fetoprotein (AFP) and albumin with an effective amount of a fatty acid or a small molecule selected from the group consisting of: an amphipathic carboxylic acid Thiazolidinedione (TZD), WY-14643 (Pirinixic Acid), GW409544, GW6471, Leukotriene B4, GW 7647, Perfluorooctanesulfonic Acid, Perfluorooctanoic Acid, CP-775146, CP-865520, UNII-999KY5ZIGB, and Gemfibrozil. Also provided are isolated hepatocytes and uses thereof.
    Type: Application
    Filed: September 14, 2020
    Publication date: March 18, 2021
    Inventors: Yaakov Nahmias, Michal Zimerman, Gahl Levy, Yishai Avior
  • Methods of inducing metabolic maturation of human pluripotent stem cells— derived hepatocytes
    Patent number: 10772863
    Abstract: Provided are methods of increasing metabolic maturation of an immature hepatocyte, by contacting an immature hepatocyte which expresses alpha-fetoprotein (AFP) and albumin with an effective amount of a fatty acid or a small molecule selected from the group consisting of: an amphipathic carboxylic acid, Thiazolidinedione (TZD), WY-14643 (Pirinixic Acid), GW409544, GW6471, Leukotriene B4, GW 7647, Perfluorooctanesulfonic Acid, Perfluorooctanoic Acid, CP-775146, CP-865520, UNII-999KY5ZIGB, and Gemfibrozil. Also provided are isolated hepatocytes and uses thereof.
    Type: Grant
    Filed: March 15, 2017
    Date of Patent: September 15, 2020
    Assignee: Yissum Research Development Company of the Hebrew University of Jerusalem Ltd
    Inventors: Yaakov Nahmias, Michal Zimerman, Gahl Levy, Yishai Avior
  • METHODS OF INDUCING METABOLIC MATURATION OF HUMAN PLURIPOTENT STEM CELLS-DERIVED HEPATOCYTES
    Publication number: 20170266145
    Abstract: Provided are methods of increasing metabolic maturation of an immature hepatocyte, by contacting an immature hepatocyte which expresses alpha-fetoprotein (AFP) and albumin with an effective amount of a fatty acid or a small molecule selected from the group consisting of: an amphipathic carboxylic acid, Thiazolidinedione (TZD), WY-14643 (Pirinixic Acid), GW409544, GW6471, Leukotriene B4, GW 7647, Perfluorooctanesulfonic Acid, Perfluorooctanoic Acid, CP-775146, CP-865520, UNII-999KY5ZIGB, and Gemfibrozil. Also provided are isolated hepatocytes and uses thereof.
    Type: Application
    Filed: March 15, 2017
    Publication date: September 21, 2017
    Inventors: Yaakov NAHMIAS, Michal ZIMERMAN, Gahl LEVY, Yishai AVIOR