Patents by Inventor Yishai REBOH

Yishai REBOH has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • SIGLEC-BASED CHIMERIC POLYPEPTIDES AND USES THEREOF
    Publication number: 20220211831
    Abstract: Provided are Siglec-based chimeric polypeptides. Accordingly there is provided a chimeric receptor comprising: (a) an extracellular domain comprising an amino acid sequence of a Siglec-7 or a Siglec-9 receptor capable of binding a Siglec-7 and/or a Siglec-9 ligand; and (b) an intracellular domain comprising an amino acid sequence capable of transmitting a co-stimulatory signal in an immune cell expressing the chimeric receptor upon binding of said extracellular domain to said ligand. Also provided are polynucleotides encoding same, cells expressing same and methods of use thereof.
    Type: Application
    Filed: April 16, 2020
    Publication date: July 7, 2022
    Applicant: Bar-Ilan University
    Inventors: Cyrille Joseph COHEN, Yishai REBOH, Sara MERIL, Vasyl EISENBERG