Patents by Inventor Yitshak Francis

Yitshak Francis has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • HISTONE ACETYLTRANSFERASE ACTIVATORS AND USES THEREOF
    Publication number: 20210317074
    Abstract: The invention provides for a method for screening compounds that bind to and modulate a histone acetyltransferase protein. The invention further provides methods for treating neurodegenerative disorders, conditions associated with accumulated amyloid-beta peptide deposits, Tau protein levels, and/or accumulations of alpha-synuclein as well as cancer by administering a HAT-activating compound to a subject.
    Type: Application
    Filed: May 11, 2021
    Publication date: October 14, 2021
    Inventors: Yan FENG, Mauro FA, Ottavio ARANCIO, Shixian DENG, Donald W. LANDRY, Yitshak FRANCIS
  • Histone acetyltransferase activators and uses thereof
    Patent number: 11034647
    Abstract: The invention provides for a method for screening compounds that bind to and modulate a histone acetyltransferase protein. The invention further provides methods for treating neurodegenerative disorders, conditions associated with accumulated amyloid-beta peptide deposits, Tau protein levels, and/or accumulations of alpha-synuclein as well as cancer by administering a HAT-activating compound to a subject.
    Type: Grant
    Filed: December 9, 2019
    Date of Patent: June 15, 2021
    Assignee: The Trustees of Columbia University in the City of New York
    Inventors: Yan Feng, Mauro Fa, Ottavio Arancio, Shixian Deng, Donald W. Landry, Yitshak Francis
  • Histone acetyltransferase activators and uses thereof
    Patent number: 10640457
    Abstract: The invention provides for a method for screening compounds that bind to and modulate a histone acetyltransferase protein. The invention further provides methods for treating neurodegenerative disorders, conditions associated with accumulated amyloid-beta peptide deposits, Tau protein levels, and/or accumulations of alpha-synuclein as well as cancer by administering a HAT-activating compound to a subject.
    Type: Grant
    Filed: June 11, 2012
    Date of Patent: May 5, 2020
    Assignee: The Trustees of Columbia University in the City of New York
    Inventors: Yan Feng, Mauro Fa, Ottavio Arancio, Shixian Deng, Donald W. Landry, Yitshak Francis
  • HISTONE ACETYLTRANSFERASE ACTIVATORS AND USES THEREOF
    Publication number: 20200115325
    Abstract: The invention provides for a method for screening compounds that bind to and modulate a histone acetyltransferase protein. The invention further provides methods for treating neurodegenerative disorders, conditions associated with accumulated amyloid-beta peptide deposits, Tau protein levels, and/or accumulations of alpha-synuclein as well as cancer by administering a HAT-activating compound to a subject.
    Type: Application
    Filed: December 9, 2019
    Publication date: April 16, 2020
    Inventors: Yan FENG, Mauro FA, Ottavio ARANCIO, Shixian DENG, Donald W. LANDRY, Yitshak FRANCIS
  • HISTONE ACETYLTRANSFERASE MODULATORS AND USES THEREOF
    Publication number: 20180244603
    Abstract: The invention provides compounds and compositions comprising compounds that modulate histone acyl transferase (HAT). The invention further provides methods for treating neurodegenerative disorders, conditions associated with accumulated amyloid-beta peptide deposits, Tau protein levels and/or accumulations of alpha-synuclein as well as cancer by administering a compound hat modulates HAT to a subject.
    Type: Application
    Filed: May 1, 2018
    Publication date: August 30, 2018
    Inventors: Yitshak FRANCIS, Mauro FA, Ottavio ARANCIO, Jole FIORITO, Shixian DENG, Donald W. LANDRY, Michal LUZAC, Yan FENG
  • Histone acetyltransferase modulators and uses thereof
    Patent number: 9969677
    Abstract: The invention provides compounds and compositions comprising compounds that modulate histone acyl transferase (HAT). The invention further provides methods for treating neurodegenerative disorders, conditions associated with accumulated amyloid-beta peptide deposits, Tau protein levels, and/or accumulations of alpha-synuclein as well as cancer by administering a compound that modulates HAT to a subject.
    Type: Grant
    Filed: December 22, 2011
    Date of Patent: May 15, 2018
    Assignee: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
    Inventors: Yitshak Francis, Mauro Fa, Ottavio Arancio, Jole Fiorito, Shixian Deng, Donald W. Landry, Michal Luzac, Yan Feng
  • USES OF HISTONE ACETYLTRANSFERASE ACTIVATORS
    Publication number: 20180050982
    Abstract: The invention provides methods for enhancing histone acylation, learning, memory and/or cognition in subjects with compound (I) or compositions comprising compound (I), or a pharmaceutically acceptable salt thereof.
    Type: Application
    Filed: October 26, 2017
    Publication date: February 22, 2018
    Inventors: Yitshak FRANCIS, Ottavio ARANCIO, Mauro FA
  • Uses of histone acetyltransferase activators
    Patent number: 9809532
    Abstract: The invention provides methods for enhancing histone acylation, learning, memory and/or cognition in subjects with compound (I) or compositions comprising compound (I), or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: June 11, 2012
    Date of Patent: November 7, 2017
    Assignee: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
    Inventors: Yitshak Francis, Ottavio Arancio, Mauro Fa
  • HISTONE ACETYLTRANSFERASE MODULATORS AND USES THEREOF
    Publication number: 20170121276
    Abstract: The invention provides compounds and compositions comprising compounds that modulate histone acyl transferase (HAT). The invention further provides methods for treating neurodegenerative disorders, conditions associated with accumulated amyloid-beta peptide deposits, Tau protein levels, and/or accumulations of alpha-synuclein as well as cancer by administering a compound that modulates HAT to a subject.
    Type: Application
    Filed: December 22, 2011
    Publication date: May 4, 2017
    Applicant: The Trustees of Columbia University in the City of New York
    Inventors: Yitshak FRANCIS, Mauro FA, Ottavio ARANCIO, Jole FIORITO, Shixian DENG, Donald W. LANDRY, Michal LUZAC, Yan FENG
  • USES OF HISTONE ACETYLTRANSFERASE ACTIVATORS
    Publication number: 20140350116
    Abstract: The invention provides methods for enhancing histone acylation, learning, memory and/or cognition in subjects with compound (I) or compositions comprising compound (I), or a pharmaceutically acceptable salt thereof.
    Type: Application
    Filed: June 11, 2012
    Publication date: November 27, 2014
    Applicant: THE TRUSTEES OF COLUMBIA UNIVERSITY INTHE CITY OF NEW YORK
    Inventors: Yitshak Francis, Ottavio Arancio, Mauro Fa
  • HISTONE ACETYLTRANSFERASE ACTIVATORS AND USES THEREOF
    Publication number: 20130121919
    Abstract: The invention provides for a method for screening compounds that bind to and modulate a histone acetyltransferase protein. The invention further provides methods for treating neurodegenerative disorders, conditions associated with accumulated amyloid-beta peptide deposits, Tau protein levels, and/or accumulations of alpha-synuclein as well as cancer by administering a HAT-activating compound to a subject.
    Type: Application
    Filed: June 11, 2012
    Publication date: May 16, 2013
    Applicant: The Trustees of Columbia University in the City of New York
    Inventors: Yan FENG, Mauro Fa, Ottavio Arancio, Shi Xian Deng, Donald W. Landry, Yitshak Francis