Patents by Inventor Yitzhak Tor

Yitzhak Tor has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20210101924
    Abstract: The disclosure provides cyclic dinucleotides that are useful as STING agonists, pharmaceutical compositions and vaccines comprising the cyclic dinucleotides, and methods of treating diseases and disorders using the cyclic dinucleotides, pharmaceutical compositions, and vaccines.
    Type: Application
    Filed: August 27, 2020
    Publication date: April 8, 2021
    Inventors: Yitzhak Tor, Yao Li, Andrea Fin
  • Patent number: 10543283
    Abstract: This disclosure relates to intranasal administration of conjugates comprising guanidinylated aminoglycosides (“guanidinoglycosides”) and a polypeptide (e.g., an enzyme, antibody, or polypeptide growth factor). For example, such administration methods are useful for delivering a polypeptide to the brain and/or cerebrospinal fluid. Such methods are useful for treating a lysosomal storage disease through intranasal administration of a conjugate comprising one or more guanidinoglycosides and an enzyme useful for treating a lysosomal storage disease.
    Type: Grant
    Filed: September 6, 2017
    Date of Patent: January 28, 2020
    Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Jeffrey D. Esko, Yitzhak Tor, Wenyong Tong
  • Patent number: 10449230
    Abstract: Provided are transporters based on polymyxin B. Also provided are methods of using the transporters for intracellular delivery of cargo and methods of enhancing intracellular uptake of cargo.
    Type: Grant
    Filed: October 6, 2017
    Date of Patent: October 22, 2019
    Assignee: The Regents of the University of California
    Inventors: Kristina Hamill, Jeffrey D. Esko, Lisa McCoy, Yitzhak Tor
  • Publication number: 20180311321
    Abstract: Reagents and methods useful for the synthesis of conjugates comprising guanidinylated cyclic acetals are provided. Also provided are methods for increasing the cellular uptake of various therapeutic compounds and treatment modalities using these conjugates.
    Type: Application
    Filed: January 25, 2018
    Publication date: November 1, 2018
    Applicant: The Regents of the University of California
    Inventors: Jeffrey D. Esko, Yitzhak Tor
  • Publication number: 20180099022
    Abstract: Provided are transporters based on polymyxin B. Also provided are methods of using the transporters for intracellular delivery of cargo and methods of enhancing intracellular uptake of cargo.
    Type: Application
    Filed: October 6, 2017
    Publication date: April 12, 2018
    Applicant: The Regents of the University of California
    Inventors: Kristina Hamill, Jeffrey D. Esko, Lisa McCoy, Yitzhak Tor
  • Publication number: 20180086782
    Abstract: This disclosure relates to the incorporation of amphiphilic guanidinylated aminoglycosides (e.g., neomycin) into liposomal assemblies, which contain entrapped therapeutics. The lysosome is responsible for enzymatically breaking down and recycling large biomolecules and aged organelles. While malfunctioned lysosomal enzymes have been established in Lysosomal Storage Disorders (LSDs), recent reports have suggested that defects in lysosomal enzymes (e.g., glucocerebrosidase) are also linked to other chronic ailments, including neurological disorders such as Parkinson's Disease and related disorders.
    Type: Application
    Filed: April 1, 2016
    Publication date: March 29, 2018
    Inventors: Jeffrey D. Esko, Yitzhak Tor
  • Publication number: 20180071401
    Abstract: This disclosure relates to intranasal administration of conjugates comprising guanidinylated aminoglycosides (“guanidinoglycosides”) and a polypeptide (e.g., an enzyme, antibody, or polypeptide growth factor). For example, such administration methods are useful for delivering a polypeptide to the brain and/or cerebrospinal fluid. Such methods are useful for treating a lysosomal storage disease through intranasal administration of a conjugate comprising one or more guanidinoglycosides and an enzyme useful for treating a lysosomal storage disease.
    Type: Application
    Filed: September 6, 2017
    Publication date: March 15, 2018
    Applicant: The Regents of the University of California
    Inventors: Jeffrey D. Esko, Yitzhak Tor, Wenyong Tong
  • Patent number: 9889182
    Abstract: Reagents and methods useful for the synthesis of conjugates comprising guanidinylated cyclic acetals are provided. Also provided are methods for increasing the cellular uptake of various therapeutic compounds and treatment modalities using these conjugates.
    Type: Grant
    Filed: September 15, 2010
    Date of Patent: February 13, 2018
    Assignee: The Regents of the University of California
    Inventors: Jeffrey D. Esko, Yitzhak Tor
  • Patent number: 9757468
    Abstract: This disclosure relates to intranasal administration of conjugates comprising guanidinylated aminoglycosides (“guanidinoglycosides”) and a polypeptide (e.g., an enzyme, antibody, or polypeptide growth factor). For example, such administration methods are useful for delivering a polypeptide to the brain and/or cerebrospinal fluid. Such methods are useful for treating a lysosomal storage disease through intranasal administration of a conjugate comprising one or more guanidinoglycosides and an enzyme useful for treating a lysosomal storage disease.
    Type: Grant
    Filed: March 13, 2014
    Date of Patent: September 12, 2017
    Assignee: The Regents of the University of California
    Inventors: Jeffrey D. Esko, Yitzhak Tor, Wenyong Tong
  • Publication number: 20160015822
    Abstract: This disclosure relates to intranasal administration of conjugates comprising guanidinylated aminoglycosides (“guanidinoglycosides”) and a polypeptide (e.g., an enzyme, antibody, or polypeptide growth factor). For example, such administration methods are useful for delivering a polypeptide to the brain and/or cerebrospinal fluid. Such methods are useful for treating a lysosomal storage disease through intranasal administration of a conjugate comprising one or more guanidinoglycosides and an enzyme useful for treating a lysosomal storage disease.
    Type: Application
    Filed: March 13, 2014
    Publication date: January 21, 2016
    Inventors: Jeffrey D. Esko, Yitzhak Tor, Wenyong Tong
  • Publication number: 20120189601
    Abstract: Reagents and methods useful for the synthesis of conjugates comprising guanidinylated cyclic acetals are provided. Also provided are methods for increasing the cellular uptake of various therapeutic compounds and treatment modalities using these conjugates.
    Type: Application
    Filed: September 15, 2010
    Publication date: July 26, 2012
    Inventors: Jeffrey D. Esko, Yitzhak Tor
  • Patent number: 8071535
    Abstract: Reagents and methods useful for the synthesis of conjugates comprising guanidinylated cyclic acetals are provided. Also provided are methods for increasing the cellular uptake of various therapeutic compounds and treatment modalities using these conjugates.
    Type: Grant
    Filed: September 10, 2004
    Date of Patent: December 6, 2011
    Assignee: The Regents of the University of California
    Inventors: Yitzhak Tor, Nathan Luedtke
  • Publication number: 20080261823
    Abstract: The present invention provides fluorescent nucleoside analogs with conjugated membered heterocycles, including furan and thiophene. The fluorescent nucleoside analogs maintain structural similarity to naturally occurring nucleoside bases, mimicking shape, size, hybridization, and recognition properties. Incorporation of the fluorescent cyclic compounds confers specific photophysical characteristics including a bathochromic (red) shift of the absorption spectrum to minimize absorption overlap with naturally occurring nucleoside bases, and a shift to the long emission wavelength in the visible range. The invention also provides for various methods of synthesizing the fluorescent nucleoside analogs and incorporating the fluorescent analogs in DNA, RNA, or oligomer synthesis. Further, methods of detecting the fluorescent nucleoside analogs in an oligonucleotide or oligomer are provided.
    Type: Application
    Filed: December 9, 2005
    Publication date: October 23, 2008
    Inventor: Yitzhak Tor
  • Publication number: 20070185040
    Abstract: Reagents and methods useful for the synthesis of conjugates comprising guanidinylated cyclic acetals are provided. Also provided are methods for increasing the cellular uptake of various therapeutic compounds and treatment modalities using these conjugates.
    Type: Application
    Filed: September 10, 2004
    Publication date: August 9, 2007
    Inventors: Yitzhak Tor, Nathan Luedtke
  • Patent number: 6833445
    Abstract: Provided are reagents and methods useful for the synthesis of guanidinylated compounds. Also provided are methods for assaying molecules, including guanidinylated molecules that modulate viral infection and replication.
    Type: Grant
    Filed: January 21, 2003
    Date of Patent: December 21, 2004
    Assignee: The Regents of the University of California
    Inventors: Murray Goodman, Yitzhak Tor, Tracy Baker, Nathan Luedtke
  • Publication number: 20030232354
    Abstract: The present invention is directed to methods and compositions for the use of electron transfer moieties with different redox potentials to electronically detect nucleic acids, particularly for the electrochemical sequencing of DNA.
    Type: Application
    Filed: January 2, 2003
    Publication date: December 18, 2003
    Inventors: Changjun Yu, Yitzhak Tor
  • Publication number: 20030232974
    Abstract: Provided are reagents and methods useful for the synthesis of guanidinylated compounds. Also provided are methods for assaying molecules, including guanidinylated molecules that modulate viral infection and replication.
    Type: Application
    Filed: January 21, 2003
    Publication date: December 18, 2003
    Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Murray Goodman, Yitzhak Tor, Tracy Baker, Nathan Luedtke
  • Publication number: 20030078416
    Abstract: The invention relates to 1,10 phenanthroline derivatives substituted at the 3-,8-positions.
    Type: Application
    Filed: May 15, 1996
    Publication date: April 24, 2003
    Inventors: YITZHAK TOR, DIMITRIOS TZALIS
  • Patent number: 6525182
    Abstract: Provided are reagents and methods useful for the synthesis of guanidinylated compounds. Also provided are methods for assaying molecules, including guanidinylated molecules that modulate viral infection and replication.
    Type: Grant
    Filed: January 22, 2001
    Date of Patent: February 25, 2003
    Assignee: Regents of the University of California
    Inventors: Murray Goodman, Yitzhak Tor, Tracy Baker, Nathan Luedtke
  • Patent number: 4964972
    Abstract: According to the invention organic monolayer films are applied to an electrically conductive substrate, resulting in an electrode which can be used in electrochemical processes. The said film serves as ultrathin membrane and allows certain selected species to approach the substrate and be detected. The film comprises active species which are selective towards specific species contained in mixture with others and a blocking surface sealing component. It is also possible to use one compound serving both purposes. The components of the film are attached to the substrate by a variety of means: adsorption, chemisorption, electro-chemical deposition.
    Type: Grant
    Filed: March 30, 1989
    Date of Patent: October 23, 1990
    Assignee: Yeda Research and Development Company Limited
    Inventors: Jacob Sagiv, Israel Rubinstein, Suzi Steinberg, Abraham Shanzer, Yitzhak Tor