Patents by Inventor Yiwen Li
Yiwen Li has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20180057591Abstract: The present invention relates to antibodies that bind human T-cell immunoglobulin- and mucin-domain-containing protein-3 (Tim-3), and may be useful for treating solid and hematological tumors alone and in combination with chemotherapy and ionizing radiation.Type: ApplicationFiled: August 17, 2017Publication date: March 1, 2018Inventors: Yi Zhang, Yang Shen, Carmine Carpenito, Yiwen Li
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Patent number: 9863911Abstract: A diagnostic Electrochemical Impedance Spectroscopy (EIS) procedure is applied to measure values of impedance-related parameters for one or more sensing electrodes. The parameters may include real impedance, imaginary impedance, impedance magnitude, and/or phase angle. The measured values of the impedance-related parameters are then used in performing sensor diagnostics, calculating a highly-reliable fused sensor glucose value based on signals from a plurality of redundant sensing electrodes, calibrating sensors, detecting interferents within close proximity of one or more sensing electrodes, and testing surface area characteristics of electroplated electrodes. Advantageously, impedance-related parameters can be defined that are substantially glucose-independent over specific ranges of frequencies. An Application Specific Integrated Circuit (ASIC) enables implementation of the EIS-based diagnostics, fusion algorithms, and other processes based on measurement of EIS-based parameters.Type: GrantFiled: August 2, 2017Date of Patent: January 9, 2018Assignee: MEDTRONIC MINIMED, INC.Inventors: Jenn-Hann Larry Wang, Michael E. Miller, Raghavendhar Gautham, Yiwen Li, Rajiv Shah
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Publication number: 20170328861Abstract: A diagnostic Electrochemical Impedance Spectroscopy (EIS) procedure is applied to measure values of impedance-related parameters for one or more sensing electrodes. The parameters may include real impedance, imaginary impedance, impedance magnitude, and/or phase angle. The measured values of the impedance-related parameters are then used in performing sensor diagnostics, calculating a highly-reliable fused sensor glucose value based on signals from a plurality of redundant sensing electrodes, calibrating sensors, detecting interferents within close proximity of one or more sensing electrodes, and testing surface area characteristics of electroplated electrodes. Advantageously, impedance-related parameters can be defined that are substantially glucose-independent over specific ranges of frequencies. An Application Specific Integrated Circuit (ASIC) enables implementation of the EIS-based diagnostics, fusion algorithms, and other processes based on measurement of EIS-based parameters.Type: ApplicationFiled: August 2, 2017Publication date: November 16, 2017Inventors: JENN-HANN LARRY WANG, MICHAEL E. MILLER, RAGHAVENDHAR GAUTHAM, YIWEN LI, RAJIV SHAH
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Publication number: 20170058033Abstract: The present invention relates to antibodies that bind human programmed cell death 1 ligand 1 (PD-L1), and may be useful for treating solid and hematological tumors alone and in combination with chemotherapy and other cancer therapeutics.Type: ApplicationFiled: August 18, 2016Publication date: March 2, 2017Inventors: Dale Lincoln Ludwig, Marshall Davenport Snavely, Yiwen Li, Juqun Shen, Vera Molkenthin
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Publication number: 20160320338Abstract: A diagnostic Electrochemical Impedance Spectroscopy (EIS) procedure is applied to measure values of impedance-related parameters for one or more sensing electrodes. The parameters may include real impedance, imaginary impedance, impedance magnitude, and/or phase angle. The measured values of the impedance-related parameters are then used in performing sensor diagnostics, calculating a highly-reliable fused sensor glucose value based on signals from a plurality of redundant sensing electrodes, calibrating sensors, detecting interferents within close proximity of one or more sensing electrodes, and testing surface area characteristics of electroplated electrodes. Advantageously, impedance-related parameters can be defined that are substantially glucose-independent over specific ranges of frequencies. An Application Specific Integrated Circuit (ASIC) enables implementation of the EIS-based diagnostics, fusion algorithms, and other processes based on measurement of EIS-based parameters.Type: ApplicationFiled: July 11, 2016Publication date: November 3, 2016Inventors: Jenn-Hann Larry Wang, Michael E. Miller, Raghavendhar Gautham, Yiwen Li, Rajiv Shah
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Patent number: 9408567Abstract: A diagnostic Electrochemical Impedance Spectroscopy (EIS) procedure is applied to measure values of impedance-related parameters for one or more sensing electrodes. The parameters may include real impedance, imaginary impedance, impedance magnitude, and/or phase angle. The measured values of the impedance-related parameters are then used in performing sensor diagnostics, calculating a highly-reliable fused sensor glucose value based on signals from a plurality of redundant sensing electrodes, calibrating sensors, detecting interferents within close proximity of one or more sensing electrodes, and testing surface area characteristics of electroplated electrodes. Advantageously, impedance-related parameters can be defined that are substantially glucose-independent over specific ranges of frequencies. An Application Specific Integrated Circuit (ASIC) enables implementation of the EIS-based diagnostics, fusion algorithms, and other processes based on measurement of EIS-based parameters.Type: GrantFiled: February 27, 2013Date of Patent: August 9, 2016Assignee: MEDTRONIC MINIMED, INC.Inventors: Jenn-Hann Larry Wang, Michael E. Miller, Raghavendhar Gautham, Yiwen Li, Rajiv Shah
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Patent number: 8808532Abstract: Embodiments of the invention provide amperometric analyte sensors having optimized elements such as electrodes formed from sputtered platinum compositions as well as layers of material selected to optimize the characteristics of a wide variety of sensor elements and sensors. While embodiments of the innovation can be used in a variety of contexts, typical embodiments of the invention include glucose sensors used in the management of diabetes.Type: GrantFiled: January 20, 2011Date of Patent: August 19, 2014Assignee: Medtronic Minimed, IncInventors: Qingling Yang, Rajiv Shah, Xiaolong Li, Barry Phong Pham, Yiwen Li
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Publication number: 20140012115Abstract: Embodiments of the invention provide methods and materials for making analyte sensors having a plurality of layered elements such as amperometric glucose sensors that are used by diabetic individuals to monitor blood sugar concentrations. Embodiments of the invention utilize plasma deposition technologies to form thin films of adhesion promoting compositions useful in such sensors. Sensors that incorporate the thin film compositions formed by these processes exhibit a number of desirable characteristics.Type: ApplicationFiled: July 3, 2012Publication date: January 9, 2014Applicant: MEDTRONIC MINIMED, INC.Inventors: Yiwen Li, Jenn-Hann Larry Wang, Rajiv Shah
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Patent number: 8608921Abstract: Embodiments of the invention provide amperometric analyte sensors having optimized elements such as electrodes formed from sputtered platinum compositions as well as layers of material selected to optimize the characteristics of a wide variety of sensor elements and sensors. While embodiments of the innovation can be used in a variety of contexts, typical embodiments of the invention include glucose sensors used in the management of diabetes.Type: GrantFiled: January 20, 2011Date of Patent: December 17, 2013Assignee: Medtronic MiniMed, Inc.Inventors: Xiaolong Li, Rajiv Shah, Qingling Yang, Yiwen Li, Barry Phong Pham
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Publication number: 20130331674Abstract: A diagnostic Electrochemical Impedance Spectroscopy (EIS) procedure is applied to measure values of impedance-related parameters for one or more sensing electrodes. The parameters may include real impedance, imaginary impedance, impedance magnitude, and/or phase angle. The measured values of the impedance-related parameters are then used in performing sensor diagnostics, calculating a highly-reliable fused sensor glucose value based on signals from a plurality of redundant sensing electrodes, calibrating sensors, detecting interferents within close proximity of one or more sensing electrodes, and testing surface area characteristics of electroplated electrodes. Advantageously, impedance-related parameters can be defined that are substantially glucose-independent over specific ranges of frequencies. An Application Specific Integrated Circuit (ASIC) enables implementation of the EIS-based diagnostics, fusion algorithms, and other processes based on measurement of EIS-based parameters.Type: ApplicationFiled: February 27, 2013Publication date: December 12, 2013Inventors: Ning Yang, Raghavendhar Gautham, Bradley C. Liang, Rajiv Shah, Catherine M. Szyman, Michael E. Miller, Jenn-Hann Larry Wang, Yiwen Li, Wayne A. Morgan, Paris Chen, Robert C. Mucic, Genival D. de Barros, Carlos A. Callirgos, Manjunath Sirigiri, Joseph Paul Brinson
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Publication number: 20130328572Abstract: A diagnostic Electrochemical Impedance Spectroscopy (EIS) procedure is applied to measure values of impedance-related parameters for one or more sensing electrodes. The parameters may include real impedance, imaginary impedance, impedance magnitude, and/or phase angle. The measured values of the impedance-related parameters are then used in performing sensor diagnostics, calculating a highly-reliable fused sensor glucose value based on signals from a plurality of redundant sensing electrodes, calibrating sensors, detecting interferents within close proximity of one or more sensing electrodes, and testing surface area characteristics of electroplated electrodes. Advantageously, impedance-related parameters can be defined that are substantially glucose-independent over specific ranges of frequencies. An Application Specific Integrated Circuit (ASIC) enables implementation of the EIS-based diagnostics, fusion algorithms, and other processes based on measurement of EIS-based parameters.Type: ApplicationFiled: February 27, 2013Publication date: December 12, 2013Inventors: Jenn-Hann Larry Wang, Michael E. Miller, Raghavendhar Gautham, Yiwen Li, Rajiv Shah
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Publication number: 20120186997Abstract: Embodiments of the invention provide amperometric analyte sensors having optimized elements such as electrodes formed from sputtered platinum compositions as well as layers of material selected to optimize the characteristics of a wide variety of sensor elements and sensors. While embodiments of the innovation can be used in a variety of contexts, typical embodiments of the invention include glucose sensors used in the management of diabetes.Type: ApplicationFiled: January 20, 2011Publication date: July 26, 2012Applicant: MEDTRONIC MINIMED, INC.Inventors: Xiaolong Li, Rajiv Shah, Qingling Yang, Yiwen Li, Barry Phong Pham
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Publication number: 20120190950Abstract: Embodiments of the invention provide amperometric analyte sensors having optimized elements such as electrodes formed from sputtered platinum compositions as well as layers of material selected to optimize the characteristics of a wide variety of sensor elements and sensors. While embodiments of the innovation can be used in a variety of contexts, typical embodiments of the invention include glucose sensors used in the management of diabetes.Type: ApplicationFiled: January 20, 2011Publication date: July 26, 2012Applicant: MEDTRONIC MINIMED, INC.Inventors: Qingling Yang, Rajiv Shah, Xiaolong Li, Barry Phong Pham, Yiwen Li
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Patent number: 8071099Abstract: The present invention provides fully human antibodies that specifically bind to human FLT3 within extracellular domains 4 or 5 with high affinity. The invention further provides methods of treating leukemia by administering an effective amount of an antibody either alone or in combination with an anti-cancer agent or treatment including methotrexate.Type: GrantFiled: September 27, 2010Date of Patent: December 6, 2011Assignee: ImClone, LLCInventors: Yiwen Li, Dan Lu, David Surguladze, James Robert Tonra
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Publication number: 20110091470Abstract: The present invention provides fully human antibodies that specifically bind to human FLT3 within extracellular domains 4 or 5 with high affinity. The invention further provides methods of treating leukemia by administering an effective amount of an antibody either alone or in combination with an anti-cancer agent or treatment including methotrexate.Type: ApplicationFiled: May 28, 2009Publication date: April 21, 2011Applicant: IMCLONE LLCInventors: Yiwen Li, Dan Lu, David Surguladze, James Robert Tonra
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Publication number: 20110008355Abstract: The present invention provides fully human antibodies that specifically bind to human FLT3 within extracellular domains 4 or 5 with high affinity. The invention further provides methods of treating leukemia by administering an effective amount of an antibody either alone or in combination with an anti-cancer agent or treatment including methotrexate.Type: ApplicationFiled: September 27, 2010Publication date: January 13, 2011Inventors: Yiwen LI, Dan LU, James Robert TONRA, David SURGULADZE
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Publication number: 20090297529Abstract: The present invention provides fully human antibodies that specifically bind to human FLT3 within extracellular domains 4 or 5 with high affinity. The invention further provides methods of treating leukemia by administering an effective amount of an antibody either alone or in combination with an anti-cancer agent or treatment including methotrexate.Type: ApplicationFiled: May 28, 2009Publication date: December 3, 2009Inventors: Yiwen Li, Dan Lu, James Robert Tonra, David Surguladze
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Publication number: 20050170445Abstract: Protein detection microarrays are used to specifically detect cytokines and growth factors that are associated with wound healing and with host organism responses to foreign, implanted materials (i.e., biocompatibility). Methods of establishing profiles that can be used in evaluating wound healing and biocompatibility take advantage of such cytokine- and growth factor-specific microarrays, which comprise anti-cytokine and anti-growth factor capture antibodies immobilized onto a solid substrate. The microarrays are produced using a printing buffer optimized for cytokine/growth factor detection. Methods of detecting the cytokines and growth factors also utilize optimized blocking buffers, fluorescent dyes, and immunoassay conditions. Sandwich and direct label fluoroimmunoassays can be carried out with the optimized microarrays.Type: ApplicationFiled: January 7, 2005Publication date: August 4, 2005Inventors: William Reichert, Yiwen Li
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Publication number: 20040247577Abstract: The present invention relates to methods of inhibiting heparanase activity and treating various conditions by administering to an animal an effective amount of an immunogen that elicits an immune response to heparanase. According to the present invention, the immunogen is heparanase or a fragment thereof and, preferably, the immunogen is an antigen presenting cell (APC), such as a dendritic cell (DC), displaying heparanase or a fragment thereof on the surface. The present invention also relates to compositions containing the immunogen.Type: ApplicationFiled: June 16, 2004Publication date: December 9, 2004Inventors: Peter Bohlen, Daniel J. Hicklin, Paul Kussie, Yiwen Li
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Patent number: 6593394Abstract: A composition for use as a bioactive bone cement having a powder component including strontium-containing hydroxy apatite and formulated to create a settable fluid substance when mixed with a liquid component. The liquid component includes a Bisphenol A diglycidylether dimethacrylate resin which when mixed with the powder component creates a bioactive bone cement. The bioactive bone cement can alternatively be in the form of a two paste component system in which a first paste component including strontium-containing hydroxy apatite, Bisphenol A diglycidylether dimethacrylate resin and a polymerization initiator is formulated to create a settable paste substance when mixed with a second paste component. The second paste component includes strontium-containing hydroxy apatite, Bisphenol A diglycidylether dimethacrylate resin, and a polymerization accelerator which when mixed together with the first paste component creates a bioactive bone cement.Type: GrantFiled: November 9, 2000Date of Patent: July 15, 2003Assignee: Prosperous Kingdom LimitedInventors: Yiwen Li, Weijia William Lu, Man Chee Kenneth Cheung, Dip Kei Keith Luk, Chi Yan John Leong