Patents by Inventor Yixian Zhang

Yixian Zhang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20220140046
    Abstract: The present application provides a display panel and a fabrication method thereof. In the display panel, a bonding module covers a display area and an extension area, and a bonding conductive layer of the bonding module is electrically connected to an external driving chip. A display module covers the display area and the extension area, the display module comprises a thin film transistor array structure, and the thin film transistor array structure comprises a source-drain conductive layer. A portion of the source-drain conductive layer in the extension area is electrically connected to the bonding conductive layer by a through hole.
    Type: Application
    Filed: June 23, 2020
    Publication date: May 5, 2022
    Applicant: Wuhan China Star Optoelectronics Semiconductor Display Technology Co., Ltd.
    Inventors: Jing ZHOU, Yixian ZHANG, Wenxu XIANYU
  • Patent number: 11227881
    Abstract: Disclosed in the present invention are a method for manufacturing a thin-film transistor, an array substrate, and a display device. The method includes: forming a buffer layer on a substrate; forming a polysilicon layer on the buffer layer; performing a patterning process on the polysilicon layer, to form an active layer; depositing a gate insulating layer on the active layer; depositing a gate metal layer on the gate insulating layer, and performing dry etching on the gate metal layer by using the patterning process and by using a gas containing CO as an etching gas, to form a gate; performing ion implantation on the active layer by using the gate as a mask, to form a source region and a drain region; and depositing a passivation layer on the gate, forming through holes in the gate insulating layer and the passivation layer, and manufacturing a source and a drain.
    Type: Grant
    Filed: July 6, 2018
    Date of Patent: January 18, 2022
    Inventors: Koji Suzuki, Zhuo Chen, Yixian Zhang, Fan Zhang, Siyu Ren, Junhai Su, Jianhua Li
  • Publication number: 20210399024
    Abstract: The present invention provides an array substrate and a manufacturing method thereof. The array substrate includes a base, a first thin film transistor (TFT), and a second TFT. The first TFT includes a first active layer, a gate insulating layer disposed on the active layer, and a first gate disposed on the first gate insulating layer. The second TFT includes a second active layer disposed on the first gate insulating layer. The first gate and the second active layer are made of a same material, and are integrally formed.
    Type: Application
    Filed: July 20, 2020
    Publication date: December 23, 2021
    Applicant: WUHAN CHINA STAR OPTOELECTRONICS SEMICONDUCTOR DISPLAY TECHNOLOGY CO., LTD.
    Inventors: Jixiang GONG, Yixian ZHANG, Wenxu XIANYU
  • Publication number: 20210391404
    Abstract: A display panel, a manufacturing method thereof, and a display device are provided. In the display panel, a conversion terminal layer is formed on a first substrate to form a conversion terminal, a first opening is formed at a position on the first substrate corresponding to the conversion terminal, and a data line formed from a source/drain layer is connected to the conversion terminal by a first through-hole. Therefore, when a driver chip is connected to the display panel, the driver chip can be connected to the data line of the source/drain layer by the conversion terminal layer.
    Type: Application
    Filed: June 23, 2020
    Publication date: December 16, 2021
    Applicant: WUHAN CHINA STAR OPTOELECTRONICS SEMICONDUCTOR DISPLAY TECHNOLOGY CO., LTD.
    Inventors: Jing ZHOU, Yixian ZHANG, Wenxu XIANYU
  • Publication number: 20200235132
    Abstract: Disclosed in the present invention are a method for manufacturing a thin-film transistor, an array substrate, and a display device. The method includes: forming a buffer layer on a substrate; forming a polysilicon layer on the buffer layer; performing a patterning process on the polysilicon layer, to form an active layer; depositing a gate insulating layer on the active layer; depositing a gate metal layer on the gate insulating layer, and performing dry etching on the gate metal layer by using the patterning process and by using a gas containing CO as an etching gas, to form a gate; performing ion implantation on the active layer by using the gate as a mask, to form a source region and a drain region; and depositing a passivation layer on the gate, forming through holes in the gate insulating layer and the passivation layer, and manufacturing a source and a drain.
    Type: Application
    Filed: July 6, 2018
    Publication date: July 23, 2020
    Inventors: Koji SUZUKI, Zhuo CHEN, Yixian ZHANG, Fan ZHANG, Siyu REN, Junhai SU, Jianhua LI
  • Patent number: 9506060
    Abstract: The disclosure relates to oligonucleotide compounds (oligomers) that target Myc mRNA in a cell, leading to reduced expression of Myc. Reduction of Myc expression is beneficial for the treatment of certain disorders, such as hyperproliferative disorders (e.g., cancer). The disclosure provides therapeutic compositions comprising oligomers and methods for modulating the expression of Myc using said oligomers, including methods of treatment.
    Type: Grant
    Filed: February 15, 2013
    Date of Patent: November 29, 2016
    Assignees: DANA-FARBER CANCER INSTITUTE, INC., ENZON PHARMACEUTICALS, INC.
    Inventors: Rajanikanth Bandaru, Yixian Zhang, Zhengxing Qu, Lee Greenberger, Christopher Ott, James Elliott Bradner
  • Publication number: 20160024495
    Abstract: The disclosure relates to oligonucleotide compounds (oligomers) that target Myc mRNA in a cell, leading to reduced expression of Myc. Reduction of Myc expression is beneficial for the treatment of certain disorders, such as hyperproliferative disorders (e.g., cancer). The disclosure provides therapeutic compositions comprising oligomers and methods for modulating the expression of Myc using said oligomers, including methods of treatment.
    Type: Application
    Filed: February 15, 2013
    Publication date: January 28, 2016
    Inventors: Rajanikanth Bandaru, Yixian Zhang, Zhengxing Qu, Lee Greenberger, Christopher Ott, James Elliott Bradner
  • Patent number: 9040493
    Abstract: The present invention relates to oligomer compounds (oligomers) for the treatment and prevention of acute myeloid leukemia, which target GLI2 mRNA in a cell, leading to reduced expression of GLI2.
    Type: Grant
    Filed: January 15, 2010
    Date of Patent: May 26, 2015
    Assignee: Santaris Pharma A/S
    Inventors: Yixian Zhang, Zhengxing Qu
  • Publication number: 20140323557
    Abstract: The invention relates to oligomer compounds (oligomers), which target beta-catenin mRNA in a cell, leading to reduced expression of beta-catenin. Reduction of beta-catenin expression is beneficial for a range of medical disorders, such as hyperproliferative disorders, such as cancers. The invention provides therapeutic compositions comprising oligomers and methods for modulating the expression of beta-catenin using said oligomers, including methods of treatment for hyperproliferative disorders including cancers such as multiple myeloma.
    Type: Application
    Filed: November 9, 2012
    Publication date: October 30, 2014
    Inventors: Melissa Dumble, Yixian Zhang
  • Publication number: 20140031409
    Abstract: The invention provides the combination use of antisense oligomers targeting androgen receptor mRNA and androgen receptor binding inhibitors that reduce androgen receptor activity for the treatment of androgen receptor related medical disorders, such as cancers, particularly prostate cancers and breast cancers.
    Type: Application
    Filed: April 30, 2013
    Publication date: January 30, 2014
    Applicants: Santaris Pharma A/S, Enzon Pharmaceuticals
    Inventors: Jesper Worm, Yixian Zhang
  • Patent number: 8450290
    Abstract: The invention provides the combination use of antisense oligomers targeting androgen receptor mRNA and androgen receptor binding inhibitors that reduce androgen receptor activity for the treatment of androgen receptor related medical disorders, such as cancers, particularly prostate cancers and breast cancers.
    Type: Grant
    Filed: November 12, 2010
    Date of Patent: May 28, 2013
    Assignees: Enzon Pharmaceuticals, Inc., Santaris Pharma A/S
    Inventors: Jesper Worm, Yixian Zhang
  • Publication number: 20120232132
    Abstract: The present invention relates to oligomer compounds (oligomers) for the treatment and prevention of acute myeloid leukemia, which target GLI2 mRNA in a cell, leading to reduced expression of GLI2.
    Type: Application
    Filed: January 15, 2010
    Publication date: September 13, 2012
    Inventors: Yixian Zhang, Zhengxing Qu
  • Publication number: 20120076781
    Abstract: One aspect of the invention provides methods for treating cancers which are resistant to treatment with a protein tyrosine kinase inhibitor by co-treatment with the protein tyrosine kinase inhibitor and one or more antisense oligomers that reduce the expression of HER3 and/or HER2 and/or EGFR. Another aspect of the invention provides methods for treating cancers by co-treatment with an inhibitor of HER2 and one or more antisense oligomers that reduce the expression of HER3.
    Type: Application
    Filed: April 14, 2010
    Publication date: March 29, 2012
    Applicants: ENZON PHARMACEUTICALS, INC.
    Inventors: Yixian Zhang, Zhengxing Qu, Lee Martin Greenberger
  • Publication number: 20120004285
    Abstract: The invention relates to pharmaceutical compositions for and methods of treatment with HER3-targeted combination therapy. The invention relates to pharmaceutical compositions comprising an oligomer which targets HER3 (and optionally one or more of HER2 and EGFR) mRNA in a cell, leading to reduced expression of HER3 and optionally HER2 and/or EGFR, and a small molecule protein tyrosine kinase inhibitor of one or more receptor tyrosine kinases, leading to inhibition of signaling and/or internalization of receptor dimers into the cell. The combination therapy is beneficial for a range of medical disorders, such hyperproliferative disorders (e.g., cancer). The invention provides methods of treating hyperproliferative disorders with a combination of an oligomer and a protein tyrosine kinase inhibitor.
    Type: Application
    Filed: November 5, 2009
    Publication date: January 5, 2012
    Applicant: ENZON PHARMACEUTICALS, INC.
    Inventors: Baisong Liao, Yixian Zhang
  • Publication number: 20110152348
    Abstract: The invention provides the combination use of antisense oligomers targeting androgen receptor mRNA and androgen receptor binding inhibitors that reduce androgen receptor activity for the treatment of androgen receptor related medical disorders, such as cancers, particularly prostate cancers and breast cancers.
    Type: Application
    Filed: November 12, 2010
    Publication date: June 23, 2011
    Applicant: Enzon Pharmaceuticals, Inc.
    Inventors: Jesper Worm, Yixian Zhang
  • Patent number: 7799915
    Abstract: The present invention relates to compounds of formula I: wherein R1, R2, R3, R4, R5, and R6 are defined herein.
    Type: Grant
    Filed: October 13, 2005
    Date of Patent: September 21, 2010
    Assignee: Wyeth LLC
    Inventors: Fuk-Wah Sum, Dennis William Powell, Yixian Zhang, Lijing Chen, Scott Lee Kincaid, Lee Dalton Jennings, Yongbo Hu, Adam Matthew Gilbert, Matthew Gregory Bursavich
  • Publication number: 20090062133
    Abstract: The invention relates to compositions, kits, and methods for detecting, characterizing, preventing, and treating prostate cancer. FKBP markers are provided, wherein changes in the levels of expression of one or more of the FKBP markers is correlated with the presence of prostate cancer.
    Type: Application
    Filed: July 3, 2008
    Publication date: March 5, 2009
    Inventors: Kimberly A. Gillis, Yixian Zhang
  • Patent number: 7402388
    Abstract: The invention relates to compositions, kits, and methods for detecting, characterizing, preventing, and treating prostate cancer. FKBP markers are provided, wherein changes in the levels of expression of one or more of the FKBP markers is correlated with the presence of prostate cancer.
    Type: Grant
    Filed: November 23, 2004
    Date of Patent: July 22, 2008
    Assignee: Wyeth
    Inventors: Kimberly A. Gillis, Yixian Zhang
  • Patent number: 7037652
    Abstract: The invention relates to methods for detecting, characterizing, preventing, and treating prostate cancer. KIAA markers are provided, wherein changes in the levels of expression of one or more of the KIAA markers is correlated with the presence of prostate cancer.
    Type: Grant
    Filed: November 28, 2001
    Date of Patent: May 2, 2006
    Assignee: Wyeth
    Inventors: Kimberly A. Gillis, Yixian Zhang
  • Publication number: 20060079543
    Abstract: The present invention relates to compounds of formula I: wherein R1, R2, R3, R4, R5, and R6 are defined herein.
    Type: Application
    Filed: October 13, 2005
    Publication date: April 13, 2006
    Applicant: Wyeth
    Inventors: Fuk-Wah Sum, Dennis Powell, Yixian Zhang, Lijing Chen, Scott Kincaid, Lee Jennings, Yongbo Hu, Adam Gilbert, Matthew Bursavich