Patents by Inventor Yixin Hu
Yixin Hu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20220281902Abstract: Compounds, compositions and methods are provided for mitochondrial modulation. The subject mitochondrial modulator compounds generally include a head group linked to a charged moiety. In certain cases, the head group is a heterocyclic or a heteroaryl group. Aspects of the subject methods include a method of modulating mitochondria. Aspects of the subject methods include treating a subject having a metabolic syndrome-related disease or a symptom thereof by administering to the subject a therapeutically effective amount of a subject compound. In certain cases, the disease is selected from hyperlipidemia, type 2 diabetes, fatty liver disease, obesity, cardiovascular disease and stroke. In certain cases, the symptom is selected from abdominal obesity, insulin resistance, hyperinsulinemia, high levels of blood fats, increased blood pressure, and elevated serum lipids.Type: ApplicationFiled: August 11, 2020Publication date: September 8, 2022Inventors: Lei Fu, Mojdeh Tavallaie, James P. Collman, Christopher J. Barile, Yixin Hu
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Publication number: 20210169546Abstract: An embodiment in accordance with the present invention provides a handheld cryoprobe for use in percutaneous cryotherapy of tumorous masses. It includes a probe attached to a CO2 gas dispensing backend. The probe has specifically optimized parameters designed for use with CO2 gas and is made out of a partially hollowed and threaded aluminum rod providing maximum heat exchange. The system backend regulates flow of compressed CO2 gas while throttling and cooling the gas coolant to the cytotoxically low temperatures necessary for targeted tumor cell death. Additionally, the incoming initial stream of CO2 gas is throttled by the Joule-Thomson nozzle on the backend. The low temperature exhaust gas is then used to pre-cool all subsequent incoming gas, resulting in an even lower temperature at the probe tip, which provides a positive feedback loop, continually decreasing the gas's temperature. The temperature drop is caused by the Joule-Thomson effect.Type: ApplicationFiled: May 1, 2019Publication date: June 10, 2021Inventors: Bailey Surtees, Evelyn McChesney, Sean Young, Yixin Hu, Nicholas James Durr, Tara Blair, Pascal Acree, Grace Kuroki, Susan C. Harvey, Serena M. Thomas
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Patent number: 10022181Abstract: The present invention includes a medical device providing for the measurement and/or monitoring of the thermal conditions and/or environment existing across a substantial portion of a thermal element disposed on the medical device and the corresponding tissue region being treated by the device. The medical device of the present invention may generally include an elongate body having a thermal element coupled thereto for providing thermal energy to a desired tissue region, as well as a thermocouple array providing a plurality of temperature measurement positions about the thermal element. The thermocouple array may include one or more thermocouple elements arranged as a mesh or wire structure disposed about a substantial portion of the surface area of the thermal element.Type: GrantFiled: September 27, 2006Date of Patent: July 17, 2018Assignee: Medtronic CryoCath LPInventors: Yixin Hu, Wlodzimierz Sadzynski, Melita A. Tabao, Teresa Mihalik
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Patent number: 9636172Abstract: A system and method for occluding a pulmonary vein. The device includes a treatment device comprising an inner balloon, an outer balloon, and a space therebetween. Delivery of fluid to the inner balloon inflates the treatment element to a first diameter. If a greater treatment element diameter is required to completely occlude a pulmonary vein, fluid is delivered to the space between the first and second balloons, which expands the second balloon and causes the treatment element to have a second diameter that is greater than the first diameter. The fluid delivered to the inner balloon and fluid delivered to the space between the balloons may be from different sources and may be delivered and exhausted independently. Once the treatment element is caused to have a diameter sufficient to completely occlude the pulmonary vein, the treatment element is activated to cool or heat ostial tissue.Type: GrantFiled: May 31, 2013Date of Patent: May 2, 2017Assignee: Medtronic CryoCath LPInventor: Yixin Hu
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Patent number: 9211393Abstract: The present invention may include a medical device having a handle, a catheter coupled to the handle, and an expandable element coupled to the catheter. The medical device may also include first and second elongate bodies that traverse a length of the handle and the catheter. A housing may be disposed within the handle, with the housing defining a first opening able to receive a portion of the first elongate body, a second opening able to receive a portion of the second elongate body, and a third opening opposite the first and second openings able to receive a portion of both the first and second elongate bodies. A separation element may be disposed within the housing, with the separation element defining a path able to receive a portion of the second elongate body, and whereby a portion of the first elongate body forms a loop around the separation element.Type: GrantFiled: June 28, 2006Date of Patent: December 15, 2015Assignee: Medtronic CryoCath LPInventors: Yixin Hu, Vladimir Tzonev, Teresa Ann Mihalik, Benoit Thibault, Dan Wittenberger, Miriam Lane, Cristian Petre
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Publication number: 20140358137Abstract: A system and method for occluding a pulmonary vein. The device includes a treatment device comprising an inner balloon, an outer balloon, and a space therebetween. Delivery of fluid to the inner balloon inflates the treatment element to a first diameter. If a greater treatment element diameter is required to completely occlude a pulmonary vein, fluid is delivered to the space between the first and second balloons, which expands the second balloon and causes the treatment element to have a second diameter that is greater than the first diameter. The fluid delivered to the inner balloon and fluid delivered to the space between the balloons may be from different sources and may be delivered and exhausted independently. Once the treatment element is caused to have a diameter sufficient to completely occlude the pulmonary vein, the treatment element is activated to cool or heat ostial tissue.Type: ApplicationFiled: May 31, 2013Publication date: December 4, 2014Inventor: Yixin HU
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Patent number: 7871395Abstract: The present invention may include a medical device having a handle, a catheter coupled to the handle, and an expandable element coupled to the catheter. The medical device may also include first and second elongate bodies that traverse a length of the handle and catheter. A housing may be disposed within the handle, wherein the housing defines a first opening able to receive a portion of the first elongate body, a second opening able to receive a portion of the second elongate body, and a third opening opposite the first and second openings able to receive a portion of both the first and second elongate bodies. A separation element may be disposed within the housing, with the separation element defining a path able to receive a portion of the second elongate body, and whereby a portion of the first elongate body forms a loop around the separation element.Type: GrantFiled: June 5, 2006Date of Patent: January 18, 2011Assignee: Medtronic Cryocath LPInventors: Yixin Hu, Teresa Mihalik, Cristian Petre, Dan Wittenberger
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Publication number: 20080097373Abstract: The present invention may include a medical device having a handle, a catheter coupled to the handle, and an expandable element coupled to the catheter. The medical device may also include first and second elongate bodies that traverse a length of the handle and catheter. A housing may be disposed within the handle, with the housing defines a first opening able to receive a portion of the first elongate body, a second opening able to receive a portion of the second elongate body, and a third opening opposite the first and second openings able to receive a portion of both the and second elongate bodies. A separation element may be disposed within the housing, with the separation element defining a path able to receive a portion of the second elongate body, and whereby a portion of the first elongate body forms a loop around the separation element.Type: ApplicationFiled: June 28, 2006Publication date: April 24, 2008Inventors: Yixin Hu, Vladimir Tzonev, Teresa Ann Mihalik, Benoit Thibault, Dan Wittenberger, Miriam Lane, Cristian Petre
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Publication number: 20080097421Abstract: The present invention includes a medical device providing for the measurement and/or monitoring of the thermal conditions and/or environment existing across a substantial portion of a thermal element disposed on the medical device and the corresponding tissue region being treated by the device. The medical device of the present invention may generally include an elongate body having a thermal element coupled thereto for providing thermal energy to a desired tissue region, as well as a thermocouple array providing a plurality of temperature measurement positions about the thermal element. The thermocouple array may include one or more thermocouple elements arranged as a mesh or wire structure disposed about a substantial portion of the surface area of the thermal element.Type: ApplicationFiled: September 27, 2006Publication date: April 24, 2008Inventors: Yixin Hu, Wlodzimierz Sadzynski, Melita A. Tabao, Teresa Mihalik
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Publication number: 20070282256Abstract: The present invention may include a medical device having a handle, a catheter coupled to the handle, and an expandable element coupled to the catheter. The medical device may also include first and second elongate bodies that traverse a length of the handle and catheter. A housing may be disposed within the handle, with the housing defines a first opening able to receive a portion of the first elongate body, a second opening able to receive a portion of the second elongate body, and a third opening opposite the first and second openings able to receive a portion of both the and second elongate bodies. A separation element may be disposed within the housing, with the separation element defining a path able to receive a portion of the second elongate body, and whereby a portion of the first elongate body forms a loop around the separation element.Type: ApplicationFiled: June 5, 2006Publication date: December 6, 2007Inventors: Yixin Hu, Teresa Mihalik, Cristian Petre, Dan Wittenberger
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Patent number: D564093Type: GrantFiled: May 8, 2006Date of Patent: March 11, 2008Assignee: CryoCath Technologies Inc.Inventors: Philippe Marchand, Yixin Hu, Ramin Sabbaghe-Kermani, Michael Bailey, Michel Morelli, André Tremblay, Teresa Mihalik, Daniel Patrick O'Sullivan, Jr., Stanley O. Thompson, Domenic Santoianni, Vincent Nicolas Gladu