Patents by Inventor Yixiong Lei

Yixiong Lei has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Synthesis and use of kinase inhibitors
    Patent number: 9505719
    Abstract: An improved synthesis of a class of inhibitor of Focal Adhesion Kinase (FAK) is provided, wherein use of an expensive palladium-based catalyst is reduced and reaction yields and product purities are improved. Two key reactions of coupling of aryl halides with anilines are optimized with the surprising discovery that the palladium-based catalyst can be dispensed with entirely in one of the reactions. The invention also provides the use of the FAK-inhibitory compounds in the treatment of inflammatory and immune disorders and of arthritis.
    Type: Grant
    Filed: August 7, 2013
    Date of Patent: November 29, 2016
    Assignee: VERASTEM, INC.
    Inventors: Yixiong Lei, Carl Henry Behrens, Hui-Yin Li, Connie L. Sun
  • SYNTHESIS AND USE OF KINASE INHIBITORS
    Publication number: 20140235635
    Abstract: An improved synthesis of a class of inhibitor of Focal Adhesion Kinase (FAK) is provided, wherein use of an expensive palladium-based catalyst is reduced and reaction yields and product purities are improved. Two key reactions of coupling of aryl halides with anilines are optimized with the surprising discovery that the palladium-based catalyst can be dispensed with entirely in one of the reactions. The invention also provides the use of the FAK-inhibitory compounds in the treatment of inflammatory and immune disorders and of arthritis.
    Type: Application
    Filed: August 7, 2013
    Publication date: August 21, 2014
    Applicant: PONIARD PHARMACEUTICALS, INC
    Inventors: Yixiong Lei, Carl Henry Behrens, Hui-Yin Li, Connie L. Sun