Patents by Inventor Yiyan He

Yiyan He has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Reduction stimulus-responsive gene delivery system and preparation and application thereof
    Patent number: 9707303
    Abstract: The present invention discloses a gene delivery system containing a reduction-sensitive shielding system having a targeting function, a preparation method and an application in the field of gene therapy thereof. The gene delivery system is composed of a reduction-sensitive shielding system having a targeting function, cationic polymer material and plasmid DNA; the cationic polymer material and the plasmid DNA complexed to form complex particles, the reduction-sensitive shielding system having a targeting function is shielded on the complex surface by means of electrostatic interaction, so as to reduce the toxicity of the delivery system and successfully transfer the loaded genetic material into cells, thereby achieving expression of genetic material and completing the transfection process, and moreover, improving the targeting and the efficiency of gene transfection.
    Type: Grant
    Filed: September 29, 2013
    Date of Patent: July 18, 2017
    Assignee: SICHUAN UNIVERSITY
    Inventors: Zhongwei Gu, Yu Nie, Yiyan He, Gang Cheng, Li Xie
  • REDUCTION STIMULUS-RESPONSIVE GENE DELIVERY SYSTEM AND PREPARATION AND APPLICATION THEREOF
    Publication number: 20150273080
    Abstract: The present invention discloses a gene delivery system containing a reduction-sensitive shielding system having a targeting function, a preparation method and an application in the field of gene therapy thereof. The gene delivery system is composed of a reduction-sensitive shielding system having a targeting function, cationic polymer material and plasmid DNA; the cationic polymer material and the plasmid DNA complexed to form complex particles, the reduction-sensitive shielding system having a targeting function is shielded on the complex surface by means of electrostatic interaction, so as to reduce the toxicity of the delivery system and successfully transfer the loaded genetic material into cells, thereby achieving expression of genetic material and completing the transfection process, and moreover, improving the targeting and the efficiency of gene transfection.
    Type: Application
    Filed: September 29, 2013
    Publication date: October 1, 2015
    Inventors: Zhongwei Gu, Yu Nie, Yiyan He, Gang Cheng, Li Xie