Patents by Inventor Yiyuan YIN

Yiyuan YIN has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • C3-BINDING AGENTS AND METHODS OF USE THEREOF
    Publication number: 20230382985
    Abstract: The present disclosure provides binding agents, such as antibodies (including single chain variable fragments), that specifically bind complement component C3, including human C3, compositions comprising same, and methods of their use. The disclosure also provides related polynucleotides and vectors encoding the binding agents and cells comprising same.
    Type: Application
    Filed: August 10, 2023
    Publication date: November 30, 2023
    Inventors: Dana Yen Mei Duey, Zhonghao Liu, Jie Tang, Yan Wang, Yiyuan Yin, Wenwu Zhai, Jared Martin Higbee
  • C3-binding agents and methods of use thereof
    Patent number: 11767359
    Abstract: The present disclosure provides binding agents, such as antibodies (including single chain variable fragments), that specifically bind complement component C3, including human C3, compositions comprising same, and methods of their use. The disclosure also provides related polynucleotides and vectors encoding the binding agents and cells comprising same.
    Type: Grant
    Filed: August 19, 2021
    Date of Patent: September 26, 2023
    Assignee: NGM Biopharmaceuticals, Inc.
    Inventors: Dana Yen Mei Duey, Zhonghao Liu, Jie Tang, Yan Wang, Yiyuan Yin, Wenwu Zhai, Jared Martin Higbee
  • Methods of lowering triglyceride levels with an ANGPTL8-binding antibody or antigen-binding fragment thereof
    Patent number: 11566067
    Abstract: The present disclosure provides binding agents, such as antibodies, that specifically bind Angiopoietin-like protein 8 (ANGPTL8), including human ANGPTL8, and methods of their use.
    Type: Grant
    Filed: August 18, 2020
    Date of Patent: January 31, 2023
    Assignee: NGM Biopharmaceuticals, Inc.
    Inventors: Chun Chu, Xunshan Ding, Zhonghao Liu, Yan Wang, Yiyuan Yin, Wenwu Zhai
  • MULTISPECIFIC ANTIGEN-BINDING PROTEINS
    Publication number: 20220409725
    Abstract: Provided are, inter alia, multispecific antigen binding proteins, or antigen-binding fragments thereof, comprising one or more mutations in the VH/VL domains and/or CH1/CL domains, pharmaceutical compositions comprising same, isolated nucleic acids, vectors, and host cells encoding/expressing same, method of making the multispecific antigen binding proteins, computer readable media for evaluating multispecific antigen binding proteins, and libraries.
    Type: Application
    Filed: August 5, 2021
    Publication date: December 29, 2022
    Applicant: Genentech, Inc.
    Inventors: Paul CARTER, Christoph SPIESS, Yiyuan YIN, Jianhui ZHOU, Wendy SANDOVAL, Jacob CORN, Michael DILLON
  • NUCLEIC ACID LINKED IMMUNE-SANDWICH ASSAY (NULISA)
    Publication number: 20220390442
    Abstract: Disclosed herein are highly sensitive immunoassays that utilize a capture/release mechanism to reduce non-specific binding and achieve detection with attomolar-level sensitivity. Kits that can be used for carrying out these highly sensitive immunoassays are also disclosed herein.
    Type: Application
    Filed: June 1, 2022
    Publication date: December 8, 2022
    Inventors: Yuling Luo, Wei Feng, Adrian Grzybowski, Yiyuan Yin, Shiping Chen
  • C3-BINDING AGENTS AND METHODS OF USE THEREOF
    Publication number: 20220119508
    Abstract: The present disclosure provides binding agents, such as antibodies (including single chain variable fragments), that specifically bind complement component C3, including human C3, compositions comprising same, and methods of their use. The disclosure also provides related polynucleotides and vectors encoding the binding agents and cells comprising same.
    Type: Application
    Filed: August 19, 2021
    Publication date: April 21, 2022
    Inventors: Dana Yen Mei Duey, Zhonghao Liu, Jie Tang, Yan Wang, Yiyuan Yin, Wenwu Zhai, Jared Martin Higbee
  • METHODS OF MAKING ANTIBODIES
    Publication number: 20220056134
    Abstract: Provided are, inter alia, methods of improving pairing of a heavy chain and a light chain of an antibody (such as a bispecific antibody). Also provided are antibodies (e.g., bispecific antibodies) generated using such methods, libraries, and methods of screening such libraries.
    Type: Application
    Filed: November 8, 2021
    Publication date: February 24, 2022
    Applicant: Genentech, Inc.
    Inventors: Kamal Kishore JOSHI, Paul J. Carter, Yiyuan Yin
  • Anti-C3 antibodies
    Patent number: 11136381
    Abstract: The present disclosure provides binding agents, such as antibodies (including single chain variable fragments), that specifically bind complement component C3, including human C3, compositions comprising same, and methods of their use. The disclosure also provides related polynucleotides and vectors encoding the binding agents and cells comprising same.
    Type: Grant
    Filed: April 1, 2019
    Date of Patent: October 5, 2021
    Assignee: NGM Biopharmaceuticals, Inc.
    Inventors: Dana Yen Mei Duey, Zhonghao Liu, Jie Tang, Yan Wang, Yiyuan Yin, Wenwu Zhai, Jared Martin Higbee
  • NUCLEIC ACID LINKED IMMUNE-SANDWICH ASSAY (NULISA)
    Publication number: 20210285941
    Abstract: Disclosed herein are highly sensitive immunoassays that utilize a capture/release mechanism to reduce non-specific binding and achieve detection with attomolar-level sensitivity. Kits that can be used for carrying out these highly sensitive immunoassays are also disclosed herein.
    Type: Application
    Filed: May 25, 2021
    Publication date: September 16, 2021
    Inventors: Yuling Luo, Wei Feng, Adrian Grzybowski, Yiyuan Yin, Shiping Chen
  • Multispecific antigen-binding proteins
    Patent number: 11116840
    Abstract: Provided are, inter alia, multispecific antigen binding proteins, or antigen-binding fragments thereof, comprising one or more mutations in the VH/VL domains and/or CH1/CL domains, pharmaceutical compositions comprising same, isolated nucleic acids, vectors, and host cells encoding/expressing same, method of making the multispecific antigen binding proteins, computer readable media for evaluating multispecific antigen binding proteins, and libraries.
    Type: Grant
    Filed: October 20, 2017
    Date of Patent: September 14, 2021
    Assignee: Genentech, Inc.
    Inventors: Paul Carter, Christoph Spiess, Yiyuan Yin, Jianhui Zhou, Wendy Sandoval, Jacob Corn, Michael Dillon
  • NUCLEIC ACID LINKED IMMUNE-SANDWICH ASSAY (NULISA)
    Publication number: 20210278398
    Abstract: Disclosed herein are highly sensitive immunoassays that utilize a capture/release mechanism to reduce non-specific binding and achieve detection with attomolar-level sensitivity. Kits that can be used for carrying out these highly sensitive immunoassays are also disclosed herein.
    Type: Application
    Filed: May 25, 2021
    Publication date: September 9, 2021
    Inventors: Yuling Luo, Wei Feng, Adrian Grzybowski, Yiyuan Yin, Shiping Chen
  • ANGPTL8-BINDING AGENTS AND METHODS OF USE THEREOF
    Publication number: 20210095014
    Abstract: The present disclosure provides binding agents, such as antibodies, that specifically bind Angiopoietin-like protein 8 (ANGPTL8), including human ANGPTL8, and methods of their use.
    Type: Application
    Filed: August 18, 2020
    Publication date: April 1, 2021
    Inventors: Chun Chu, Xunshan Ding, Zhonghao Liu, Yan Wang, Yiyuan Yin, Wenwu Zhai
  • ANGPTL8-binding agents and methods of use thereof
    Patent number: 10774139
    Abstract: The present disclosure provides binding agents, such as antibodies, that specifically bind Angiopoietin-like protein 8 (ANGPTL8), including human ANGPTL8, and methods of their use.
    Type: Grant
    Filed: November 8, 2018
    Date of Patent: September 15, 2020
    Assignee: NGM Biopharmaceuticals, Inc.
    Inventors: Chun Chu, Xunshan Ding, Zhonghao Liu, Yan Wang, Yiyuan Yin, Wenwu Zhai
  • C3-BINDING AGENTS AND METHODS OF USE THEREOF
    Publication number: 20190322730
    Abstract: The present disclosure provides binding agents, such as antibodies (including single chain variable fragments), that specifically bind complement component C3, including human C3, compositions comprising same, and methods of their use. The disclosure also provides related polynucleotides and vectors encoding the binding agents and cells comprising same.
    Type: Application
    Filed: April 1, 2019
    Publication date: October 24, 2019
    Inventors: Dana Yen Mei Duey, Zhonghao Liu, Jie Tang, Yan Wang, Yiyuan Yin, Wenwu Zhai, Jared Martin Higbee
  • ANGPTL8-BINDING AGENTS AND METHODS OF USE THEREOF
    Publication number: 20190169281
    Abstract: The present disclosure provides binding agents, such as antibodies, that specifically bind Angiopoietin-like protein 8 (ANGPTL8), including human ANGPTL8, and methods of their use.
    Type: Application
    Filed: November 8, 2018
    Publication date: June 6, 2019
    Inventors: Chun Chu, Xunshan Ding, Zhonghao Liu, Yan Wang, Yiyuan Yin, Wenwu Zhai
  • Anti-FGFR2/3 antibodies and methods using same
    Patent number: 10208120
    Abstract: The invention provides dual specific anti-FGFR2 and FGFR3 (FGFR2/3) antibodies, and compositions comprising and methods of using these antibodies.
    Type: Grant
    Filed: November 5, 2015
    Date of Patent: February 19, 2019
    Assignee: GENENTECH, INC.
    Inventors: Yiyuan Yin, Avi Ashkenazi, Paul J. Carter, Mark Chen, Junichiro Sonoda
  • MULTISPECIFIC ANTIGEN-BINDING PROTEINS
    Publication number: 20180177873
    Abstract: Provided are, inter alia, multispecific antigen binding proteins, or antigen-binding fragments thereof, comprising one or more mutations in the VH/VL domains and/or CH1/CL domains, pharmaceutical compositions comprising same, isolated nucleic acids, vectors, and host cells encoding/expressing same, method of making the multispecific antigen binding proteins, computer readable media for evaluating multispecific antigen binding proteins, and libraries.
    Type: Application
    Filed: October 20, 2017
    Publication date: June 28, 2018
    Applicant: Genentech, Inc.
    Inventors: PAUL CARTER, CHRISTOPH SPIESS, YIYUAN YIN, JIANHUI ZHOU, WENDY SANDOVAL, JACOB CORN, MICHAEL DILLON
  • ANTI-FGFR2/3 ANTIBODIES AND METHODS USING SAME
    Publication number: 20160244525
    Abstract: The invention provides dual specific anti-FGFR2 and FGFR3 (FGFR2/3) antibodies, and compositions comprising and methods of using these antibodies.
    Type: Application
    Filed: November 5, 2015
    Publication date: August 25, 2016
    Applicant: GENENTECH, INC.
    Inventors: Yiyuan YIN, Avi ASHKENAZI, Paul J. CARTER, Mark CHEN, Junichiro SONODA