Patents by Inventor Yizhen Xie

Yizhen Xie has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20210169958
    Abstract: The present invention relates to a preparation method of Agrocybe aegerita extract and its use in the preparation of lowering uric acid drugs, including: (1) Crush the dried fruit bodies of Agrocybe aegerita; (2) Separate the filter residue and the filtrate within 120 hours of extraction with 100-3000% ethanol by volume weight percentage at 0-100° C., and repeat it for 1-10 times; (3) Combine the filtrates obtained in step (2), concentrate to 25-35 mL and freeze-dry to obtain the alcohol extract; (4) Use 100-3000% water by volume percentage as a solvent to extract the alcohol-extracted filter residues of step (2) at 0-100° C. within 120 hours, separate the filter residue and the filtrate, repeat it for 1-10 times; (5) The filtrates obtained in step (4) are combined and concentrated to 25-35 mL, and lyophilized to obtain the water extract.
    Type: Application
    Filed: August 14, 2018
    Publication date: June 10, 2021
    Inventors: Tianqiao Yong, Yizhen Xie, Chunwei Jiao, Danling Liang
  • Publication number: 20210130767
    Abstract: The invention relates to a rare edible fungus new strain and an artificial cultivation method and use thereof, in particular to a new species Pholiota glutinosior of genus Pholota and its artificial cultivation method and use. The new strain of genus Pholiota of the present invention is collected from the Guangdong Chebaling National Nature Reserve, and is identified as a new strain of genus Pholiota, and the original strain is obtained by tissue separation, and is named as HMGIM-W140054, deposited on Jun. 3, 2019, at China Center for Type Culture Collection (CCTCC, Wuhan, China), with the accession number CCTCC NO: M 2019414. The new strain of the invention has been artificially domesticated and cultivated, exhibits a strong and significant inhibition rate against Staphylococcus, and has a high content of histidine, crude polysaccharide and potassium. It is rich in nutrients and has high cultivation yield, and is a new species with high development prospects.
    Type: Application
    Filed: March 27, 2020
    Publication date: May 6, 2021
    Inventors: Qingping Wu, Huiping Hu, Yuanchao Liu, Xiaowei Liang, Yizhen Xie, Zhi Zhang
  • Patent number: 10183028
    Abstract: The invention provides an enrichment method of Ergosterol peroxide from sporoderm-broken Ganoderma lucidum spore powder, comprising the steps of preparing crude extract containing Ergosterol peroxide, purification by medium pressure preparative chromatography, purification by simulated moving-bed, and recrystallization. The operation of this invention is simple and stable, with higher yield and low cost, suitable for industrial-scale production.
    Type: Grant
    Filed: December 1, 2015
    Date of Patent: January 22, 2019
    Assignees: Guangdong Yuewei Edible Fungi Technology Co, Ltd., Guangzhou Polysarm Bioscience Corp.
    Inventors: Burton B. Yang, Yizhen Xie, Chunwei Jiao, Ou Shuai, Xiangmin Li
  • Patent number: 10155822
    Abstract: A Grifola frondosa polysaccharide F2 with hypoglycemic activity, process for preparation and use thereof. The process for preparation of Grifola frondosa polysaccharide F2 is as follows: The fruit bodies of Grifola frondosa were homogenized to a fine powder and extracted with hot water. The mixture was filtered and precipitated with absolute ethanol. The precipitation was obtained. The said precipitation was applied on DEAE Sepharose Fast chromatographic column, equilibrated with Tris-HCl (10 mM, pH=8.0), collecting the efficient eluting peak to obtain the fraction F1; eluted with Tris-HCl (10 mM, pH=8.0) which contains 0.1M NaCl, fraction F2 was obtained; then concentrated under reduced pressure, dialyzed and lyophilized, Grifola frondosa polysaccharide F2 was obtained. This isolates a new Grifola frondosa polysaccharide F2 with hypoglycemic activity from the fruit bodies of Grifola frondosa. The Grifola frondosa polysaccharide F2 can be used in manufacturing a drug for treating diabetes.
    Type: Grant
    Filed: January 24, 2017
    Date of Patent: December 18, 2018
    Assignees: Guangdong Institute of Microbiology, Guangdong Yuewei Edible Fungi Technology Co., Ltd.
    Inventors: Qingping Wu, Chun Xiao, Yizhen Xie, Xiaobing Yang, Senzhu Li
  • Publication number: 20170360802
    Abstract: The invention provides an enrichment method of Ergosterol peroxide from sporoderm-broken Ganoderma lucidum spore powder, comprising the steps of preparing crude extract containing Ergosterol peroxide, purification by medium pressure preparative chromatography, purification by simulated moving-bed, and recrystallization. The operation of this invention is simple and stable, with higher yield and low cost, suiting for industrial continuous production.
    Type: Application
    Filed: December 1, 2015
    Publication date: December 21, 2017
    Inventors: Burton B. Yang, Yizhen Xie, Chunwei Jiao, Ou Shuai, Xiangmin Li
  • Publication number: 20170260299
    Abstract: A Grifola frondosa polysaccharide F2 with hypoglycemic activity, process for preparation and use thereof. The process for preparation of Grifola frondosa polysaccharide F2 is as follows: The fruit bodies of Grifola frondosa were homogenized to a fine powder and extracted with hot water. The mixture was filtered and precipitated with absolute ethanol. The precipitation was obtained. The said precipitation was applied on DEAE Sepharose Fast chromatographic column, equilibrated with Tris-HCl (10 mM, pH=8.0), collecting the efficient eluting peak to obtain the fraction F1; eluted with Tris-HCl (10 mM, pH=8.0) which contains 0.1M NaCl, fraction F2 was obtained; then concentrated under reduced pressure, dialyzed and lyophilized, Grifola frondosa polysaccharide F2 was obtained. This isolates a new Grifola frondosa polysaccharide F2 with hypoglycemic activity from the fruit bodies of Grifola frondosa. The Grifola frondosa polysaccharide F2 can be used in manufacturing a drug for treating diabetes.
    Type: Application
    Filed: January 24, 2017
    Publication date: September 14, 2017
    Inventors: Qingping Wu, Chun Xiao, Yizhen Xie, Xiaobing Yang, Senzhu Li
  • Publication number: 20150175715
    Abstract: A Grifola frondosa polysaccharide F2 with hypoglycemic activity, process for preparation and use thereof. The process for preparation of Grifola frondosa polysaccharide F2 is as follows: The fruit bodies of Grifola frondosa were homogenized to a fine powder and extracted with hot water. The mixture was filtered and precipitated with absolute ethanol. The precipitation was obtained. The said precipitation was applied on DEAE Sepharose Fast chromatographic column, equilibrated with Tris-HCl(10 mM, pH=8.0), collecting the efficient eluting peak to obtain the fraction F1; eluted with Tris-HCl(10 mM, pH=8.0) which contains 0.1M NaCl, fraction F2 was obtained; then concentrated under reduced pressure, dialyzed and lyophilized, Grifola frondosa polysaccharide F2 was obtained. This isolates a new Grifola frondosa polysaccharide F2 with hypoglycemic activity from the fruit bodies of Grifola frondosa. The Grifola frondosa polysaccharide F2 can be used in manufacturing a drug for treating diabetes.
    Type: Application
    Filed: November 20, 2014
    Publication date: June 25, 2015
    Inventors: Qingping Wu, Chun Xiao, Yizhen Xie, Xiaobing Yang, Senzhu Li