Patents by Inventor Yizhi Qi

Yizhi Qi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PURIFIED SAPONINS AND CHROMATOGRAPHIC PROCESS FOR PURIFICATION OF SAME
    Publication number: 20230287038
    Abstract: Substantially pure saponin extracts and orthogonal chromatographic methods for purification of saponin extracts are disclosed. The purified saponin extracts may include QS-21 and can have a purity of greater than 97%. The orthogonal chromatographic method uses reversed-phase (RP) chromatography followed by hydrophilic interaction liquid chromatography (HILIC) to generate substantially pure saponin extracts.
    Type: Application
    Filed: June 4, 2021
    Publication date: September 14, 2023
    Inventors: Yizhi QI, Christopher Bradford FOX
  • Surfaces having reduced non-specific binding and antigenicity
    Patent number: 11752213
    Abstract: Disclosed herein are compositions and methods for reducing the antigenicity of molecules. The antigenicity of a molecule may be reduced or eliminated by conjugating at least one branched polymer to the molecule to form a molecule-polymer conjugate. The branched polymer may include a backbone and a plurality of side chains, each side chain covalently attached to the backbone.
    Type: Grant
    Filed: September 9, 2020
    Date of Patent: September 12, 2023
    Assignee: Duke University
    Inventors: Angus Hucknall, Ashutosh Chilkoti, Daniel Joh, Nancy J. Ganson, Yizhi Qi, Michael S. Hershfield
  • SURFACES HAVING REDUCED NON-SPECIFIC BINDING AND ANTIGENICITY
    Publication number: 20210046188
    Abstract: Disclosed herein are compositions and methods for reducing the antigenicity of molecules. The antigenicity of a molecule may be reduced or eliminated by conjugating at least one branched polymer to the molecule to form a molecule-polymer conjugate. The branched polymer may include a backbone and a plurality of side chains, each side chain covalently attached to the backbone.
    Type: Application
    Filed: September 9, 2020
    Publication date: February 18, 2021
    Inventors: Angus Hucknall, Ashutosh Chilkoti, Daniel Joh, Nancy J. Ganson, Yizhi Qi, Michael S. Hershfield
  • Polymer conjugates having reduced antigenicity and methods of using the same
    Patent number: 10392611
    Abstract: Disclosed herein are compositions and methods for reducing the antigenicity of molecules, wherein the molecule comprises a uricase. The antigenicity of a molecule may be reduced or eliminated by conjugating at least one branched polymer to the molecule to form a molecule-polymer conjugate. The branched polymer may include a backbone and a plurality of side chains, each side chain covalently attached to the backbone.
    Type: Grant
    Filed: December 21, 2016
    Date of Patent: August 27, 2019
    Assignee: Duke University
    Inventors: Ashutosh Chilkoti, Yizhi Qi, Michael S. Hershfield, Nancy J. Ganson
  • Polymer conjugates having reduced antigenicity and methods of using the same
    Patent number: 10364451
    Abstract: Disclosed herein are compositions and methods for reducing the antigenicity of molecules. The antigenicity of a molecule may be reduced or eliminated by conjugating at least one branched polymer to the molecule to form a molecule-polymer conjugate. The branched polymer may include a backbone and a plurality of side chains, each side chain covalently attached to the backbone.
    Type: Grant
    Filed: December 21, 2016
    Date of Patent: July 30, 2019
    Assignee: Duke University
    Inventors: Ashutosh Chilkoti, Yizhi Qi, Michael S. Hershfield, Nancy J. Ganson
  • POLYMER CONJUGATES HAVING REDUCED ANTIGENICITY AND METHODS OF USING THE SAME
    Publication number: 20190015520
    Abstract: Disclosed herein are compositions and methods for reducing the antigenicity of molecules. The antigenicity of a molecule may be reduced or eliminated by conjugating at least one branched polymer to the molecule to form a molecule-polymer conjugate. The branched polymer may include a backbone and a plurality of side chains, each side chain covalently attached to the backbone.
    Type: Application
    Filed: December 21, 2016
    Publication date: January 17, 2019
    Inventors: Ashutosh Chilkoti, Yizhi Qi, Michael S. Hershfield, Nancy J. Ganson
  • POLYMER CONJUGATES HAVING REDUCED ANTIGENICITY AND METHODS OF USING THE SAME
    Publication number: 20180369399
    Abstract: Disclosed herein are compositions and methods for reducing the antigenicity of molecules, wherein the molecule comprises a uricase. The antigenicity of a molecule may be reduced or eliminated by conjugating at least one branched polymer to the molecule to form a molecule-polymer conjugate. The branched polymer may include a backbone and a plurality of side chains, each side chain covalently attached to the backbone.
    Type: Application
    Filed: December 21, 2016
    Publication date: December 27, 2018
    Inventors: Michael S. Hershfield, Nancy J. Ganson, Ashutosh Chilkoti, Yizhi Qi
  • ENZYME-CATALYZED SYNTHESIS OF SITE-SPECIFIC AND STOICHIOMETRIC BIOMOLECULE-POLYMER CONJUGATES
    Publication number: 20180221496
    Abstract: Methods for producing polypeptide-polymer conjugates include attachment of an initiator agent to a polypeptide specifically at the C-terminus of the polypeptide using a sortase enzyme and in situ polymerization of a polymer from the C-terminus. The polypeptide-polymer conjugates may have desirable pharmacological properties and may be used therapeutically.
    Type: Application
    Filed: April 4, 2018
    Publication date: August 9, 2018
    Inventors: Ashutosh Chilkoti, Yizhi Qi
  • ENZYME-CATALYZED SYNTHESIS OF SITE-SPECIFIC AND STOICHIOMETRIC BIOMOLECULE-POLYMER CONJUGATES
    Publication number: 20170360946
    Abstract: Methods for producing polypeptide-polymer conjugates include attachment of an initiator agent to a polypeptide specifically at the C-terminus of the polypeptide using a sortase enzyme and in situ polymerization of a polymer from the C-terminus. The polypeptide-polymer conjugates may have desirable pharmacological properties and may be used therapeutically.
    Type: Application
    Filed: January 26, 2017
    Publication date: December 21, 2017
    Inventors: Ashutosh Chilkoti, Yizhi Qi
  • POLYMER CONJUGATES HAVING REDUCED ANTIGENICITY AND METHODS OF USING THE SAME
    Publication number: 20170239363
    Abstract: Disclosed herein are compositions and methods for reducing the antigenicity of molecules. The antigenicity of a molecule may be reduced or eliminated by conjugating at least one branched polymer to the molecule to form a molecule-polymer conjugate. The branched polymer may include a backbone and a plurality of side chains, each side chain covalently attached to the backbone.
    Type: Application
    Filed: December 21, 2016
    Publication date: August 24, 2017
    Inventors: Ashutosh Chilkoti, Yizhi Qi, Michael S. Hershfield, Nancy J. Ganson
  • POLYMER CONJUGATES HAVING REDUCED ANTIGENICITY AND METHODS OF USING THE SAME
    Publication number: 20170233714
    Abstract: Disclosed herein are compositions and methods for reducing the antigenicity of molecules, wherein the molecule comprises a uricase. The antigenicity of a molecule may be reduced or eliminated by conjugating at least one branched polymer to the molecule to form a molecule-polymer conjugate. The branched polymer may include a backbone and a plurality of side chains, each side chain covalently attached to the backbone.
    Type: Application
    Filed: December 21, 2016
    Publication date: August 17, 2017
    Inventors: Ashutosh Chilkoti, Yizhi Qi, Michael S. Hershfield, Nancy J. Ganson
  • Enzyme-catalyzed synthesis of site-specific and stoichiometric biomolecule-polymer conjugates
    Patent number: 9592303
    Abstract: Methods for producing polypeptide-polymer conjugates include attachment of an initiator agent to a polypeptide specifically at the C-terminus of the polypeptide using a sortase enzyme and in situ polymerization of a polymer from the C-terminus. The polypeptide-polymer conjugates may have desirable pharmacological properties and may be used therapeutically.
    Type: Grant
    Filed: May 30, 2014
    Date of Patent: March 14, 2017
    Assignee: Duke University
    Inventors: Ashutosh Chilkoti, Yizhi Qi
  • ENZYME-CATALYZED SYNTHESIS OF SITE-SPECIFIC AND STOICHIOMETRIC BIOMOLECULE-POLYMER CONJUGATES
    Publication number: 20160122451
    Abstract: Methods for producing polypeptide-polymer conjugates include attachment of an initiator agent to a polypeptide specifically at the C-terminus of the polypeptide using a sortase enzyme and in situ polymerization of a polymer from the C-terminus. The polypeptide-polymer conjugates may have desirable pharmacological properties and may be used therapeutically.
    Type: Application
    Filed: May 30, 2014
    Publication date: May 5, 2016
    Inventors: Ashutosh Chilkoti, Yizhi Qi