Patents by Inventor Yli Remo Vallejo
Yli Remo Vallejo has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20220236265Abstract: The present disclosure provides methods and lateral flow devices for detecting a plurality of target analytes in a liquid sample. In some implementations, the disclosed lateral flow device comprises a housing unit, a capillary flow bed, a sample-receiving zone, a buffer-receiving zone, and a capture zone. The device is configured to control the flow of the sample and reagent buffer in a sequential manner with minimal mixing. In some implementations, the disclosed method is capable of detecting a plurality of target analytes in an assay by applying the binding agents and the signaling agents in separate or sequential steps.Type: ApplicationFiled: April 4, 2022Publication date: July 28, 2022Inventors: Gregory M. Lawrence, Adam P. Lousararian, Yli Remo Vallejo, Lisa Shinefeld
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Patent number: 11293922Abstract: The present disclosure provides methods and lateral flow devices for detecting a plurality of target analytes in a liquid sample. In some implementations, the disclosed lateral flow device comprises a housing unit, a capillary flow bed, a sample-receiving zone, a buffer-receiving zone, and a capture zone. The device is configured to control the flow of the sample and reagent buffer in a sequential manner with minimal mixing. In some implementations, the disclosed method is capable of detecting a plurality of target analytes in an assay by applying the binding agents and the signaling agents in separate or sequential steps.Type: GrantFiled: July 27, 2018Date of Patent: April 5, 2022Assignee: Verax Biomedical IncorporatedInventors: Yli Remo Vallejo, Gregory M. Lawrence, Adam P. Lousararian, Lisa Shinefeld
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Patent number: 10458916Abstract: A device and method for the rapid on-site detection of inhibitors of enzymes, such as, acetylcholinesterase is described where the device contains 2 reaction zones containing a reporter enzyme substrate. One reaction zone is for the test sample while the other is for an onboard negative control. Sample and control fluids are preincubated with the enzyme in separate reaction containers, then an aliquot of each reaction mixture is added to designated reaction zones on the test device. A purpose-built reader or an illuminating device, such as, containing an incandescent light source, a diode, a UV light source or any other illumination source that is suitable for the reporter or mere visualization is used to determine the level of reporter.Type: GrantFiled: August 17, 2015Date of Patent: October 29, 2019Assignee: ANP Technologies, Inc.Inventors: Yli Remo Vallejo, Jr., David Milunic
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Patent number: 10274501Abstract: Assays for detecting antibodies to pharmaceutical preparations, food allergens and environmental allergens are described.Type: GrantFiled: April 30, 2016Date of Patent: April 30, 2019Assignee: ANP Technologies, Inc.Inventors: Ray Yin, Jing Pan, Yli Remo Vallejo, Thomas Small, Dujie Qin, De Chen
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Publication number: 20190079085Abstract: The present disclosure provides methods and lateral flow devices for detecting a plurality of target analytes in a liquid sample. In some implementations, the disclosed lateral flow device comprises a housing unit, a capillary flow bed, a sample-receiving zone, a buffer-receiving zone, and a capture zone. The device is configured to control the flow of the sample and reagent buffer in a sequential manner with minimal mixing. In some implementations, the disclosed method is capable of detecting a plurality of target analytes in an assay by applying the binding agents and the signaling agents in separate or sequential steps.Type: ApplicationFiled: July 27, 2018Publication date: March 14, 2019Inventors: Gregory M. Lawrence, Yli Remo Vallejo, Adam P. Lousararian, Lisa Shinefeld
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Patent number: 9850522Abstract: A device and method for the rapid on-site detection of inhibitors of enzymes, such as acetylcholinesterase, is described wherein the device contains all reagents added to a sample pad containing dried releasable enzyme creating a reaction mixture wherein inhibitor deactivates the enzyme, while said reaction mixture travels via a longitudinal membrane to a distal porous pad containing a substrate for the enzyme. The reaction of the enzyme and the substrate results in a product that can generate a measurable signal such as color, fluorescence or luminescence to serve as a reporter. Signal that is generated at this reaction zone is inversely proportional to inhibitor concentration in the test sample. A device containing two such strips, one for a test sample, the other for a negative control fluid as an onboard comparator is described.Type: GrantFiled: January 22, 2014Date of Patent: December 26, 2017Assignee: ANP Technologies, Inc.Inventors: Yli Remo Vallejo, Jr., David Milunic, Ray Yin, Renee Street, De Chen
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Publication number: 20160327569Abstract: Assays for detecting antibodies to pharmaceutical preparations, food allergens and environmental allergens are described.Type: ApplicationFiled: April 30, 2016Publication date: November 10, 2016Applicant: ANP Technologies, Inc.Inventors: Ray Yin, Jing Pan, Yli Remo Vallejo, Thomas Small, Dujie Qin, De Chen
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Patent number: 9329187Abstract: Assays for detecting antibodies to pharmaceutical preparations, food allergens and environmental allergens are described.Type: GrantFiled: August 17, 2015Date of Patent: May 3, 2016Assignee: ANP Technologies, Inc.Inventors: Ray Yin, Jing Pan, Yli Remo Vallejo, Thomas Small, Dujie Qin, De Chen
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Publication number: 20160041186Abstract: Assays for detecting antibodies to pharmaceutical preparations, food allergens and environmental allergens are described.Type: ApplicationFiled: August 17, 2015Publication date: February 11, 2016Inventors: Ray Yin, Jing Pan, Yli Remo Vallejo, Thomas Small, Dujie Qin, De Chen
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Publication number: 20150368691Abstract: A device and method for the rapid on-site detection of inhibitors of enzymes, such as acetylcholinesterase, is described wherein the device contains all reagents added to a sample pad containing dried releasable enzyme creating a reaction mixture wherein inhibitor deactivates the enzyme, while said reaction mixture travels via a longitudinal membrane to a distal porous pad containing a substrate for the enzyme. The reaction of the enzyme and the substrate results in a product that can generate a measurable signal such as color, fluorescence or luminescence to serve as a reporter. Signal that is generated at this reaction zone is inversely proportional to inhibitor concentration in the test sample. A device containing two such strips, one for a test sample, the other for a negative control fluid as an onboard comparator is described.Type: ApplicationFiled: January 22, 2014Publication date: December 24, 2015Inventors: Yli Remo Vallejo, JR., David Milunic, Ray Yin, Renee Street, De Chen
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Publication number: 20150353987Abstract: A device and method for the rapid on-site detection of inhibitors of enzymes, such as, acetylcholinesterase is described where the device contains 2 reaction zones containing a reporter enzyme substrate. One reaction zone is for the test sample while the other is for an onboard negative control. Sample and control fluids are preincubated with the enzyme in separate reaction containers, then an aliquot of each reaction mixture is added to designated reaction zones on the test device. A purpose-built reader or an illuminating device, such as, containing an incandescent light source, a diode, a UV light source or any other illumination source that is suitable for the reporter or mere visualization is used to determine the level of reporter.Type: ApplicationFiled: August 17, 2015Publication date: December 10, 2015Inventors: Yli Remo Vallejo, JR., David Milunic
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Publication number: 20140004547Abstract: A device and method for the rapid on-site detection of inhibitors of enzymes, such as, acetylcholinesterase is described where the device contains 2 reaction zones containing a reporter enzyme substrate. One reaction zone is for the test sample while the other is for an onboard negative control. Sample and control fluids are preincubated with the enzyme in separate reaction containers, then an aliquot of each reaction mixture is added to designated reaction zones on the test device. A purpose-built reader or an illuminating device, such as, containing an incandescent light source, a diode, a UV light source or any other illumination source that is suitable for the reporter or mere visualization is used to determine the level of reporter.Type: ApplicationFiled: March 22, 2012Publication date: January 2, 2014Applicant: ANP Technologies Inc.Inventors: Yli Remo Vallejo, David Milunic
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Publication number: 20120220051Abstract: Assays for detecting antibodies to pharmaceutical preparations, food allergens and environmental allergens are described.Type: ApplicationFiled: May 7, 2010Publication date: August 30, 2012Applicant: ANP TECHNOLOGIES, INC.Inventors: Ray Yin, Jing Pang, Yli Remo Vallejo, JR., Thomas Small, Dujie Qin, De Chen
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Patent number: 8206661Abstract: An assay device for testing of liquid samples for drugs of abuse has a transparent container for retaining a liquid sample. A backing member is within the container and is curved so that its front surface corresponds to the curvature of the container wall. Immunoassay test strips are on the front face of the backing and are visible through the container wall. Each test strip is enclosed in a transparent pocket which has a bottom opening through which the bottom portion of the test strip protrudes to contact the liquid sample within the container. The liquid then flows upwardly through the test strip to react with reagents within the test strip.Type: GrantFiled: March 24, 2009Date of Patent: June 26, 2012Assignee: American Bio Medica CorporationInventors: Yli Remo Vallejo, Martin Gould
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Patent number: 7713475Abstract: A lateral flow immunoassay test device is provided that includes a housing with an elongated slot for holding a test sample collector; an elongated holder member for securing at least one immunoassay test strip therein; a first chamber for storing a first, pre-treatment reagent; and a second chamber for storing a second reagent. Methods of conducting lateral flow immunoassays are also provided. The device and methods of conducting lateral flow immunoassays as provided herein are advantageous in that they allow pre-treatment and pre-incubation of the test sample so that the sample flows onto the test strip more easily and provide for increases in the sensitivity of the assay.Type: GrantFiled: August 14, 2006Date of Patent: May 11, 2010Assignee: American Bio Medica CorporationInventors: Martin Gould, Yli Remo Vallejo, Robert Bernstine
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Publication number: 20090181471Abstract: An assay device for testing of liquid samples for drugs of abuse has a transparent container for retaining a liquid sample. A backing member is within the container and is curved so that its front surface corresponds to the curvature of the container wall. Immunoassay test strips are on the front face of the backing and are visible through the container wall. Each test strip is enclosed in a transparent pocket which has a bottom opening through which the bottom portion of the test strip protrudes to contact the liquid sample within the container. The liquid then flows upwardly through the test strip to react with reagents within the test strip.Type: ApplicationFiled: March 24, 2009Publication date: July 16, 2009Inventors: Yli Remo VALLEJO, Martin GOULD
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Patent number: 7507373Abstract: An assay device for testing of liquid samples for drugs of abuse has a transparent container for retaining a liquid sample. A backing member is within the container and is curved so that its front surface corresponds to the curvature of the container wall. Immunoassay test strips are on the front face of the backing and are visible through the container wall. Each test strip is enclosed in a transparent pocket which has a bottom opening through which the bottom portion of the test strip protrudes to contact the liquid sample within the container. The liquid then flows upwardly through the test strip to react with reagents within the test strip.Type: GrantFiled: December 9, 2004Date of Patent: March 24, 2009Assignee: American Bio Medica Corp.Inventors: Yli Remo Vallejo, Martin Gould
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Patent number: 7090803Abstract: A lateral flow immunoassay test device that includes a housing with an elongated slot for holding a test sample collector; an elongated holder member for securing at least one immunoassay test strip therein; a first chamber for storing a first, pre-treatment reagent; and a second chamber for storing a second reagent. The pre-treatment reagent is contained within a rupturable enclosure. A piercing member is located within the housing that is used to rupture the enclosure in order to release the pre-treatment reagent so that the sample and pre-treatment reagent form a mixture. The second reagent may then be introduced to the mixture which is allowed to react with the second reagent for a period of time. The mixture and second reagent combination is then contacted with the immunoassay test strip.Type: GrantFiled: October 28, 2003Date of Patent: August 15, 2006Assignee: American Bio Medica CorporationInventors: Martin Gould, Yli Remo Vallejo, Robert Bernstine