Abstract: A method for producing a glass substrate includes (a) a step of forming molten glass having a temperature T2 less than or equal to 1500° C. on molten tin having an iron concentration greater than or equal to 100 ppm to produce a glass ribbon having a temperature T4 less than or equal to 1100° C. and a logarithm log ? greater than or equal to 8.8, and (b) a step of cooling the glass ribbon to room temperature to produce the glass substrate. The temperature T2 represents a temperature when a logarithm of a viscosity ? (dPa·s) is 2, the temperature T4 represents a temperature when the logarithm of the viscosity ? (dPa·s) is 4, and the logarithm log ? represents a logarithm of a volume resistivity ? (?·cm) at 150° C.

Abstract: The present invention provides for a process for preparing a recombinant human thrombin. A process for preparing a recombinant human thrombin which comprises: (1) obtaining a transfectant cell producing a human prothrombin by introducing an expression vector, wherein a gene fragment coding for a human prothrombin gene is incorporated, into an animal cell; (2) purifying a human prothrombin from the culture of the transfectant cell above by an anion exchanger; (3) converting the purified human prothrombin into a human thrombin by subjecting said human prothrombin to the action of ecarin; and (4) purifying the human thrombin from the solution after treatment with ecarin by an affinity method using benzamidine and a cation exchanger, and human thrombin obtained by said process, and a CHO cell that produces human prothrombin.

Abstract: The present invention provides a DNA fragment exhibiting a potent promoter activity when used in the yeast.

Abstract: A peptide comprising a peptide (A) of an amino acid sequence being abundant in basic amino acid residues and a peptide (B) of an amino acid sequence comprising at least two consecutive, hydrophobic amino acid residues wherein the peptide (B) is linked to the C-terminal of the peptide (A) directly or via several amino acid residues. The novel peptide of the present invention has the activity to inhibit growth of smooth muscle cells and a pharmaceutical composition comprising the peptide is useful for preventing or treating pathological conditions associated with growth of smooth muscle cells such as arteriosclerosis, restenosis after angioplasty, luminal stenosis after grafting blood vessel and smooth muscle sarcoma.

Abstract: There is provided an inhibitor of angiogenesis induced by growth of the vascular endothelial cells that comprises Tissue Factor Pathway Inhibitor (TFPI) as an active ingredient. The TFPI-containing preparation of the present invention can effectively inhibit angiogenesis induced by growth of the vascular endothelial cells, and thus, is quite efficacious for preventing and treating the conditions of diseases associated with angiogenesis such as malignant tumors.