Abstract: The present invention provides compositions and methods for improved T-cell therapy of cancer characterized by overexpression of Her2/neu oncogene. Provided are T cells capable of expressing or expressing chimeric antigen receptor (CAR) that specifically recognizes Her2/neu. These T cells have prolonged half-life in the blood circulation and enhanced cytotoxicity, and are used in treatment of a cancer characterized by overexpression of Her2/neu oncogene.

Abstract: Hybrid heating system including: a heat pump water heating system; sensors, for measuring a system parameter; an input arrangement providing cost data pertaining to a first power cost for supplying power to the heat pump system, and to cost information pertaining to a second power cost for operating a conventional heating system; a processor storing criteria specifying when to operate the heat pump and conventional systems, the processor receiving and processing: cost data; cost information; system parameter data; flow information on a heat exchange system circulation arrangement, and heat pump system power consumption information and concurrently operating, upon demand, the heat pump system and a chiller system in opposite heating modes; wherein, when the chiller system operates in a cooling mode, the processor processes the cost data and information, system parameter data, and flow and power consumption information, and controls the systems based on the criteria.

Abstract: Hybrid heating system including: a heat pump water heating system; sensors, for measuring a system parameter; an input arrangement providing cost data pertaining to a first power cost for supplying power to the heat pump system, and to cost information pertaining to a second power cost for operating a conventional heating system; a processor storing criteria specifying when to operate the heat pump and conventional systems, the processor receiving and processing: cost data; cost information; system parameter data; flow information on a heat exchange system circulation arrangement, and heat pump system power consumption information; and concurrently operating, upon demand, the heat pump system and a chiller system in opposite heating modes; wherein, when the chiller system operates in a cooling mode, the processor processes the cost data and information, system parameter data, and flow and power consumption information, and controls the systems based on the criteria.

Abstract: A hybrid heating system and method including: (a) a heat pump water heating system; (b) a conventional heating system including a conventional heater having a surface heat exchanger, and a primary circulation arrangement fluidly communicating with the surface exchanger, the primary circulation arrangement adapted to effect an exchange of heat between the surface heat exchanger and a flow of liquid to produce a heated flow of liquid; (c) a plurality of sensors associated with the heat exchange system; (d) an input arrangement adapted to provide cost data pertaining to a first power cost for supplying power to the heat pump system, and to cost information pertaining to a second power cost for operating the conventional system, and (e) a processor including a memory storing criteria specifying when to operate the heat pump water heating system, and when to operate the conventional heating system.

Abstract: A hybrid heating system and method including: (a) a heat pump water heating system; (b) a conventional heating system including a conventional heater having a surface heat exchanger, and a primary circulation arrangement fluidly communicating with the surface exchanger, the primary circulation arrangement adapted to effect an exchange of heat between the surface heat exchanger and a flow of liquid to produce a heated flow of liquid; (c) a plurality of sensors associated with the heat exchange system; (d) an input arrangement adapted to provide cost data pertaining to a first power cost for supplying power to the heat pump system, and to cost information pertaining to a second power cost for operating the conventional system, and (e) a processor including a memory storing criteria specifying when to operate the heat pump water heating system, and when to operate the conventional heating system.