Abstract: Abuse-resistant therapeutic pharmaceutical formulations include a cationic drug and at least one anionic polymer. Particular arrangements of the cationic drug and the at least one anionic polymer prevent the cationic drug from being extracted from the formulations in solvents and conditions commonly used by drug abusers attempting to isolate the cationic drug from its formulation.

Abstract: The invention enables the formation of prescription drugs less likely to be abused. Different approaches are employed that can potentially deter abuse by reducing the efficacy of main processes utilized by abusers to speed drug absorption and enhance its effect. Pharmaceutical compositions of the invention incorporate one or more of the following elements: super water-absorbency, alcohol absorption, organic binding agents, inorganic binding agents, adsorption, and tough platforms. These compositions function by preventing the isolation and concentration of drug constituents for misuse and/or preventing excessive intake. Thus, the invention encompasses various compositions and methods for reducing abuse of pharmaceutical products and alcohol.