Patents by Inventor Yogesh S. Sanghvi

Yogesh S. Sanghvi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 6867294
    Abstract: Novel chiral compounds that mimic and/or modulate the activity of wild-type nucleic acids are disclosed. In general, the compounds are phosphorothioate oligonucleotides wherein the 5?, and the 3?-terminal internucleoside linkages are chirally Sp and internal internucleoside linkages are chirally Rp.
    Type: Grant
    Filed: November 12, 1999
    Date of Patent: March 15, 2005
    Assignee: ISIS Pharmaceuticals, Inc.
    Inventors: Yogesh S. Sanghvi, Muthiah Manoharan
  • Patent number: 6822089
    Abstract: Methods for preparing deoxynucleosides from their corresponding ribonucleosides by forming 3-tert-butylphenoxythiocarbonylderivatives of the ribonucleosides and subsequently effecting radical deoxygenation reactions at the carbon atoms to be deoxygenated.
    Type: Grant
    Filed: March 29, 2000
    Date of Patent: November 23, 2004
    Assignee: ISIS Pharmaceuticals, Inc.
    Inventors: Yogesh S. Sanghvi, Zhiqiang Guo
  • Patent number: 6809195
    Abstract: The present invention discloses methods for synthesizing oligomeric compounds. The methods include a modified phosphoramidite protocol wherein the oxidation and capping steps are combined into a single step. The methods result in increased efficiency and are especially amenable to the large scale synthesis of oligomeric compounds.
    Type: Grant
    Filed: August 16, 2000
    Date of Patent: October 26, 2004
    Assignee: ISIS Pharmaceuticals, Inc.
    Inventors: Yogesh S. Sanghvi, Quanlai Song
  • Publication number: 20040198972
    Abstract: The present invention discloses methods for synthesizing oligomeric compounds. The methods include a modified phosphoramidite protocol wherein the oxidation and capping steps are combined into a single step. The methods result in increased efficiency and are especially amenable to the large scale synthesis of oligomeric compounds.
    Type: Application
    Filed: April 21, 2004
    Publication date: October 7, 2004
    Applicant: ISIS Pharmaceuticals, Inc.
    Inventors: Yogesh S. Sanghvi, Quanlai Song
  • Patent number: 6800751
    Abstract: Silylating reagents having a group other than a divalent oxygen separating two silyl groups provide regioselective protection of reactive groups under robust conditions, such as basic conditions used in alkylation, acylation and deoxygenation. In particular, silylating reagents having a group other than oxygen separating two silyl groups are useful for protecting two hydroxy groups of a ribonucleic or deoxyribonucleic acid. Alkylation of a 2′-hydroxy group of a ribonucleoside protected with the inventive silylating agents in the presence of an excess of a mild hindered base such as sodium HMDS may be carried out without protecting the exocyclic amine and oxo functionalities of nucleobases.
    Type: Grant
    Filed: April 11, 2002
    Date of Patent: October 5, 2004
    Assignees: ISIS Pharmaceuticals, Inc., The Regents of the University of California
    Inventors: Yogesh S. Sanghvi, Emmanuel A. Theodorakis, Ke Wen
  • Publication number: 20040096947
    Abstract: The present invention is directed to methods for the preparation of 3′-O and 5′-O-levulinyl nucleosides from common precursors using an enzymatic approach.
    Type: Application
    Filed: November 3, 2003
    Publication date: May 20, 2004
    Inventors: Yogesh S. Sanghvi, Vicente Gotor, Miguel Ferrero, Susana Fernandez, Javier Garcia
  • Patent number: 6677120
    Abstract: The present invention is directed to methods for the preparation of 3′-O and 5′-O-levulinyl nucleosides from common precursors using an enzymatic approach.
    Type: Grant
    Filed: March 30, 2001
    Date of Patent: January 13, 2004
    Assignee: ISIS Pharmaceuticals, Inc.
    Inventors: Yogesh S. Sanghvi, Vicente Gotor, Miguel Ferrero, Susana Fernandez, Javier Garcia
  • Publication number: 20030225262
    Abstract: Silylating reagents having a group other than a divalent oxygen separating two silyl groups provide regioselective protection of reactive groups under robust conditions, such as basic conditions used in alkylation, acylation and deoxygenation. In particular, silylating reagents having a group other than oxygen separating two silyl groups are useful for protecting two hydroxy groups of a ribonucleic or deoxyribonucleic acid. Alkylation of a 2′-hydroxy group of a ribonucleoside protected with the inventive silylating agents in the presence of an excess of a mild hindered base such as sodium HMDS may be carried out without protecting the exocyclic amine and oxo functionalities of nucleobases.
    Type: Application
    Filed: April 11, 2002
    Publication date: December 4, 2003
    Inventors: Yogesh S. Sanghvi, Emmanuel A. Theodorakis, Ke Wen
  • Patent number: 6642367
    Abstract: Oligonucleotide analogs are disclosed having pyrimidine monomeric sub-units therein that are modified at the 2′ and 5′ positions. Monomeric sub-units having these modifications may be further modified at the 2′ position. Improved processes for the synthesis of 2′-O-substituted pyrimidine nucleosides are also provided. The processes feature alkylation of a 2,2′-anhydropyrimidine nucleoside or a 2S,2′-anhydropyrimidine nucleoside with a weak nucleophile in the presence of a Lewis acid.
    Type: Grant
    Filed: December 22, 2000
    Date of Patent: November 4, 2003
    Assignee: ISIS Pharmaceuticals, Inc.
    Inventors: Phillip Dan Cook, Yogesh S. Sanghvi, Kelly G. Sprankle, Bruce S. Ross, Rich H. Griffey, Robert H. Springer
  • Patent number: 6541626
    Abstract: Methods for selectively protecting the exocyclic amino function of a purine nucleoside are provided using activating agents to effect acylation at the exocyclic amino site. Methods are also provided for recycling polymer bound coupling supports from the reaction mixtures produced upon N-acylation.
    Type: Grant
    Filed: April 17, 2001
    Date of Patent: April 1, 2003
    Assignees: ISIS Pharmaceuticals, Inc., University of Allahabad
    Inventors: Yogesh S. Sanghvi, Krishna Misra, Snehlata Tripathi
  • Publication number: 20030050454
    Abstract: oligonucleotide analogs are disclosed having pyrimidine monomeric sub-units therein that are modified at the 2′ and 5′ positions. Monomeric sub-units having these modifications may be further modified at the 2′ position. Improved processes for the synthesis of 2′-O-substituted pyrimidine nucleosides are also provided. The processes feature alkylation of a 2,2′-anhydropyrimidine nucleoside or a 2S,2′-anhydropyrimidine nucleoside with a weak nucleophile in the presence of a Lewis acid.
    Type: Application
    Filed: December 22, 2000
    Publication date: March 13, 2003
    Applicant: ISIS Pharmaceuticals, Inc.
    Inventors: Phillip Dan Cook, Yogesh S. Sanghvi, Kelly G. Sprankle, Bruce S. Ross, Rich H. Griffey, Robert H. Springer
  • Publication number: 20030022862
    Abstract: Methods for selectively protecting the exocyclic amino function of a purine nucleoside are provided using activating agents to effect acylation at the exocyclic amino site. Methods are also provided for recycling polymer bound coupling supports from the reaction mixtures produced upon N-acylation.
    Type: Application
    Filed: April 17, 2001
    Publication date: January 30, 2003
    Inventors: Yogesh S. Sanghvi, Krishna Misra, Snehlata Tripathi
  • Publication number: 20020142307
    Abstract: The present invention is directed to methods for the preparation of 3′—O and 5′—O—levulinyl nucleosides from common precursors using an enzymatic approach.
    Type: Application
    Filed: March 30, 2001
    Publication date: October 3, 2002
    Inventors: Yogesh S. Sanghvi, Vicente Gotor, Miguel Ferrero, Susana Fernandez, Javier Garcia
  • Patent number: 6359124
    Abstract: Compositions and methods are provided for the modulation of expression of the human ras gene in both the normal and activated forms. Oligonucleotides are provided that have methylene(methylimino) linkages alternating with phosphorothioate or phosphodiester linkages. Further oligonucleotides are provide that have a first region having a methylene(methylimino) linkage alternating with a phosphorothioate or phosphodiester linkage and a second region having phosphorothioate linkages. Such oligonucleotides can be used for diagnostics as well as for research purposes including methods for diagnosis, detection and treatment of conditions arising from the activation of the H-ras gene.
    Type: Grant
    Filed: February 12, 1999
    Date of Patent: March 19, 2002
    Assignee: ISIS Pharmaceuticals, Inc.
    Inventors: David J. Ecker, Phillip Dan Cook, Brett P. Monia, Susan M. Freier, Yogesh S. Sanghvi
  • Patent number: 6271357
    Abstract: Novel compounds that mimic and/or modulate the activity of wild-type nucleic acids. In general, the compounds contain a selected sequence of nucleosidic bases or other reactive groups that are covalently bound through nitrogen-containing linear, hairpin, dumbbell, and circular shaped tethers.
    Type: Grant
    Filed: July 17, 1998
    Date of Patent: August 7, 2001
    Assignee: Isis Pharmaceuticals, Inc.
    Inventors: Phillip D. Cook, Yogesh S. Sanghvi
  • Patent number: 6239220
    Abstract: The present invent n provides a method for the preparation of triarylmethyl protecting group reagents. The reagents are prepared from reaction effluent from the cleavage step of oligonucleotide synthetic regimes.
    Type: Grant
    Filed: July 16, 1999
    Date of Patent: May 29, 2001
    Assignee: Isis Pharmaceuticals, Inc.
    Inventors: Yogesh S. Sanghvi, Zhiqiang Guo
  • Patent number: 6222025
    Abstract: Oligonucleotide analogs are disclosed having pyrimidine monomeric sub-units therein that are modified at the 2′ and 5 positions. Monomeric sub-units having these modifications may be further modified at the 2 position. Improved processes for the synthesis of 2′-O-substituted pyrimidine nucleosides are also provided. The processes feature alkylation of a 2,2′-anhydropyrimidine nucleoside or a 2S,2′-anhydropyrimidine nucleoside with a weak nucleophile in the presence of a Lewis acid.
    Type: Grant
    Filed: January 7, 1998
    Date of Patent: April 24, 2001
    Assignee: Isis Pharmaceuticals, Inc.
    Inventors: Phillip Dan Cook, Yogesh S. Sanghvi, Kelly G. Sprankle, Bruce S. Ross, Rich H. Griffey, Robert H. Springer
  • Patent number: 6214551
    Abstract: Novel compounds that mimic and/or modulate the activity of wild-type nucleic acids. In general, the compounds contain a selected nucleoside sequence wherein the nucleosides are covalently bound through linking groups that contain adjacent nitrogen atoms.
    Type: Grant
    Filed: July 27, 1998
    Date of Patent: April 10, 2001
    Assignee: Isis Pharmaceuticals, Inc.
    Inventors: Yogesh S. Sanghvi, Phillip Dan Cook
  • Patent number: 6166197
    Abstract: Oligonucleotide analogs are disclosed having pyrimidine monomeric sub-units therein that are modified at the 2' and 5 positions. Monomeric sub-units having these modifications may be further modified at the 2 position.
    Type: Grant
    Filed: March 6, 1995
    Date of Patent: December 26, 2000
    Assignee: ISIS Pharmaceuticals, Inc.
    Inventors: Phillip Dan Cook, Yogesh S. Sanghvi, Kelly G. Sprankle, Bruce S. Ross, Rich H. Griffey
  • Patent number: 6124484
    Abstract: The present invention provides a method for the preparation of triarylmethyl protecting group reagents. The reagents are prepared from reaction effluent from the cleavage step of oligonucleotide synthetic regimes.
    Type: Grant
    Filed: July 17, 1998
    Date of Patent: September 26, 2000
    Assignee: Isis Pharmaceuticals, Inc.
    Inventors: Yogesh S. Sanghvi, Zhiqiang Guo