Abstract: A neural interfacing device is disclosed. The neural interfacing device includes a microneedle electrode. The microneedle electrode includes a body having a void formed therein and a plurality of microneedles. The void surrounds the plurality of microneedles, and the plurality of microneedles are bent outward with respect to the body to form a three-dimensional microneedle electrode. Additionally, each of the plurality of microneedles is sized and shaped to penetrate a nerve epineurium.

Abstract: A cryoablation system is provided that can assume a directional activated state and includes a cryoablation probe and a controller. The cryoablation probe has an active region that includes a cooling compartment and an opposing heating compartment that are thermally insulated from one another to minimize energy losses therebetween such that ice is selectively and directionally formed at the target site. The cooling compartment can include a temperature sensor and an exhaust tube to guide a fluid or gas that exhibits a Joule Thomson cooling effect through the probe. The heating compartment can include a temperature sensor and a heater cartridge having a heater zone. The controller of the cryoablation system can process temperature measurement data from the sensors of the heating and cooling compartments and regulate the heater zone based on the temperature measurement data processing to maintain a temperature that is sufficiently constant to mitigate or prevent formation of ice on the heating compartment.

Abstract: An epoxy-functionalized polyorganosiloxane toughener providing toughening properties for thermosetting resins is described. The epoxy-functionalized polyorganosiloxane toughener is an epoxy-functionalized siloxane polyether with a siloxane backbone, at least one epoxy-containing alkyl chain, and at least one alkoxyl polyether chain, each said at least one epoxy-containing alkyl chain and at least one alkoxyl polyether chain grafted to the siloxane backbone. Also disclosed is a thermosetting resin-based composition comprising the epoxy-functionalized polyorganosiloxane toughener of claim 1 and at least one of an epoxy resin, a hardener, and an accelerator.

Abstract: Device, systems, and methods for cryoablation are described herein. In some implementations, the devices and systems are used to for cryoneurolysis or cryoablation of nerves. An example cryoablation probe includes a tubular member having a proximal end and a distal end. The tubular member has a probe tip arranged at the distal end. The probe also includes one or more energy elements arranged along an axial direction of the tubular member, and one or more sensor elements arranged along the axial direction of the tubular member.

Abstract: Introducers for detachably coupling with an ablation probe are described herein. The ablation probe can be a cryoablation probe or other type of ablation probe such as microwave or RF ablation probe. An example introducer includes a hollow member; and a locking mechanism configured to secure the introducer and the ablation probe. An example system includes an ablation probe; and an introducer that is configured to detachably couple with the ablation probe. The introducer includes a hollow member, one or more energy elements arranged along an axial direction of the hollow member, and one or more sensor elements arranged along the axial direction of the hollow member.

Abstract: A neural interfacing device is disclosed. The neural interfacing device includes a microneedle electrode. The microneedle electrode includes a body having a void formed therein and a plurality of microneedles. The void surrounds the plurality of microneedles, and the plurality of microneedles are bent outward with respect to the body to form a three-dimensional microneedle electrode. Additionally, each of the plurality of microneedles is sized and shaped to penetrate a nerve epineurium.

Abstract: A neural interfacing device is disclosed. The neural interfacing device may include at least one microneedle electrode. The microneedle electrode may have one or more microneedles. The one or more microneedles may be shaped and positioned such that when the neural interfacing device is applied to a nerve, the one or more microneedles penetrate a nerve epineurium without any portion of the microneedle electrode penetrating any nerve axon beyond a depth of 500 micrometers.

Abstract: Portable microbial load detection is disclosed. For example, a test strip includes a calibration well with first, second, and third calibration traces and a sample well with first, second, and third test traces. A reader is configured to detect a connection with the test strip. A drive signal is applied to the test strip. A first voltage of the second calibration trace is measured indicating a reagent has been added to the calibration well. A second voltage of the third calibration trace is measured over a calibration time period and then used to calibrate the reader. An addition of a test sample in the sample well based is detected. A third voltage of the third test trace is measured over a test time period. A concentration of a detectable compound in the test sample is calculated and used to report a diagnosis state.

Abstract: An epoxy-functionalized polyorganosiloxane toughener providing toughening properties for thermosetting resins is described. The epoxy-functionalized polyorganosiloxane toughener is an epoxy-functionalized siloxane polyether with a siloxane backbone, at least one epoxy-containing alkyl chain, and at least one alkoxyl polyether chain, each said at least one epoxy-containing alkyl chain and at least one alkoxyl polyether chain grafted to the siloxane backbone. Also disclosed is a thermosetting resin-based composition comprising the epoxy-functionalized polyorganosiloxane toughener of claim 1 and at least one of an epoxy resin, a hardener, and an accelerator.

Abstract: A novel phosphate polyol formulation is described, comprising a polyester polyol, a flame retardant comprising a phosphate polyol, a blowing agent, a catalyst, a surfactant, and a fire-retardant aromatic isocyanate. A further embodiment includes a phosphorus compound, such as a phosphate, a phosphate ester, or an alkyl phosphate such as triethyl phosphate.

Abstract: Portable microbial load detection is disclosed. For example a test strip includes a calibration well with first, second, and third calibration traces and a sample well with first, second, and third test traces. A reader is configured to detect a connection with the test strip. A drive signal is applied to the test strip. A first voltage of the second calibration trace is measured indicating a reagent has been added to the calibration well. A second voltage of the third calibration trace is measured over a calibration time period and then used to calibrate the reader. An addition of a test sample in the sample well based is detected. A third voltage of the third test trace is measured over a test time period. A concentration of the compound in the test sample is calculated and used to report a diagnosis state.

Abstract: A novel phosphate polyol formulation is described, comprising a polyester polyol, a flame retardant comprising a phosphate polyol, a blowing agent, a catalyst, a surfactant, and a fire-retardant aromatic isocyanate. A further embodiment includes a phosphorus compound, such as a phosphate, a phosphate ester, or an alkyl phosphate such as triethyl phosphate.

Abstract: A neural interfacing device is disclosed. The neural interfacing device may include at least one microneedle electrode. The microneedle electrode may have one or more microneedles. The one or more microneedles may be shaped and positioned such that when the neural interfacing device is applied to a nerve, the one or more microneedles penetrate a nerve epineurium without any portion of the microneedle electrode penetrating any nerve axon beyond a depth of 500 micrometers.

Abstract: Disclosed are methods and systems for automatically displaying media items (130) preselected by a user (110) on a collage display (700) located at a social gathering spot when the user is present. A user of the system sets up a personal online profile (110) through a website (100,200) and the profile identifies a portable device (500) associated with the user. User online profiles (110) are stored in a database (400) on a system web server (300), and may include selected media items (132) selected by the user. At a venue, the user's presence is automatically detected by various electronic means, and a personalized welcome message (702) may be displayed on the collage display screen (700) to notify other patrons of the venue. Users present may comment or vote (182,184) on the media items seen on the collage display, as well as send text messages to the display (164,750).

Abstract: Disclosed is a device for causing the transdermal flux of a per meant into a subject via at least one formed pathway through a skin layer of the subject. The device comprises a delivery reservoir comprising: i) a non-biodegradable matrix having a bottom surface and defining a plurality of conduits therein the matrix, at least a portion of the plurality of conduits being in communication with the bottom surface; and ii)an undissolved hydrophilic per meant disposed therein at least a portion of the plurality of conduits of the matrix, wherein the hydrophilic per meant can come in contact with subcutaneous fluid from the subject when the bottom surface of the matrix is positioned in fluid communication with the at least one formed pathway. Also disclosed are systems and methods for causing the transdermal flux of a per meant into a subject via at least one formed pathway through a skin layer of the subject.