Abstract: The present invention provides benzothiadiazepine derivatives having the following formula and pharmaceutically acceptable salts thereof which have excellent antiarrhythmic action, local anesthetic action and calcium antagonistic action and which are very useful as cardiovascular agents such as antiarrhythmic agents and the like ##STR1## wherein R.sup.1 is lower alkyl or ##STR2## R.sup.3 is hydrogen atom, lower alkoxyl or halogen atom, one or 2 to 3 same or different substituents represented by R.sup.3 may be used, R.sup.2 is ##STR3## or --(CH.sub.2)nCO.sub.2 R.sup.6, n is an integer of 1 to 4, R.sup.4 and R.sup.5 are same or different and are each hydrogen atom or lower alkyl, R.sup.4 and R.sup.5 may link together to form a ring and the ring may include oxygen atom or nitrogen atom, R.sup.6 is hydrogen atom or lower alkyl.

Abstract: Disclosed is an iron-5,10,15,20-tetra(.alpha., .alpha., .alpha., .alpha.-o-substituted phenyl)porphine complex having one or four substituents with a phosphocholine group at the terminal end thereof. The substituents are positioned ortho of the phenyl group or groups.