Patents by Inventor Yohannes T. Ghebremariam

Yohannes T. Ghebremariam has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Dimethylarginine Dimethylaminohydrolase Inhibitors and Methods of Use Thereof
    Publication number: 20150238472
    Abstract: The present disclosure provides DDAH modulators. Thus, the present disclosure provides a method of treating a patient suffering from a disorder characterized by excessive NO production and/or elevated DDAH activity, the method comprising administering to said patient an effective amount of a compound of one of formulae I-X. The present disclosure also provides a pharmaceutical composition comprising a compound of one of formulae I-X.
    Type: Application
    Filed: March 20, 2015
    Publication date: August 27, 2015
    Inventors: Yohannes T. Ghebremariam, John P. Cooke
  • Dimethylarginine dimethylaminohydrolase inhibitors and methods of use thereof
    Patent number: 9011882
    Abstract: The present disclosure provides DDAH modulators. Thus, the present disclosure provides a method of treating a patient suffering from a disorder characterized by excessive NO production and/or elevated DDAH activity, the method comprising administering to said patient an effective amount of a compound of one of formulae I-X. The present disclosure also provides a pharmaceutical composition comprising a compound of one of formulae I-X.
    Type: Grant
    Filed: February 13, 2013
    Date of Patent: April 21, 2015
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Yohannes T. Ghebremariam, John P. Cooke
  • Cell-Free Synthesis of Active Reprogramming Transcription Factors
    Publication number: 20120208232
    Abstract: Compositions and methods are provided for the cell-free synthesis of active reprogramming factor polypeptides. The reprogramming factors may be synthesized as fusion proteins comprising a permeant domain, such as polyarginme. The cell free-synthesis may be conducted at about 25 C in a bacterial cell extract from genetically alterd cells having decreased endogenous protease activity Further, the proteins may comprise a fusion partner which enhances solubility and may be refolded on a column.
    Type: Application
    Filed: July 14, 2010
    Publication date: August 16, 2012
    Inventors: William Yang, Kedar Patel, Yohannes T. Ghebremariam, Ji Eun Lee, Hann-Chung Wong, John P. Cooke, James Robert Swartz