Abstract: The present disclosure proposes a system for detecting a foreign material adhering to or a scratch formed on a bevel at an edge of a semiconductor wafer in order to detect the foreign material or defect on the bevel without using a reference image and including a learning device (905) that outputs information on the foreign material adhering to or the scratch formed on the bevel as a learning result, in which the learning device performs learning in advance by using image data acquired by an image acquisition tool and the information on the foreign material or the scratch on the bevel included in the image data, and the foreign material or the scratch is detected by inputting the image data obtained by the image acquisition tool to the learning device (refer to FIG. 9).

Abstract: An object of the present disclosure is to provide a defect classification device capable of easily grasping an appropriate recipe update timing of an imaging device when classification accuracy for classifying defects existing on a semiconductor wafer is decreased. The defect classification device according to the present disclosure calculates classification accuracy by further acquiring a result of a manual classification for defects spanning a plurality of classification spaces as a result of an automatic classification, and comparing the result of the automatic classification with the result of the manual classification (see FIG. 5).

Abstract: Provided are a cyclic peptide compound or a pharmacologically acceptable salt thereof capable of inhibiting parakeratosis of skin, and a method for producing the same.

Abstract: Provided are a cyclic peptide compound or a pharmacologically acceptable salt thereof capable of inhibiting parakeratosis of skin, and a method for producing the same.

Abstract: The object of the present invention is to provide an oligopeptide having hair growth promoting activity. The present invention provides an oligopeptide which is represented by the formula (I): X1-X2-X3-X4-X5-X6-X7, or the like wherein X1 represents an amino acid residue such as Ser, X2 represents an amino acid residue such as Ile, X3 represents an amino acid residue such as Glu, X4 represents an amino acid residue such as Gln, X5 represents an amino acid residue such as Ser, X6 represents the amino acid residue Cys to which a modifying group containing a carbonyl group binds, or the amino acid residue Lys to which a modifying group containing a carbonyl group binds, and X7 represents an amino acid residue such as Glu or Ala.

Abstract: The object of the present invention is to provide an oligopeptide having hair growth promoting activity. The present invention provides an oligopeptide which is represented by the formula (I): X1-X2-X3-X4-X5-X6-X7, or the like wherein X1 represents an amino acid residue such as Ser, X2 represents an amino acid residue such as Ile, X3 represents an amino acid residue such as Glu, X4 represents an amino acid residue such as Gln, X5 represents an amino acid residue such as Ser, X6 represents the amino acid residue Cys to which a modifying group containing a carbonyl group binds, or the amino acid residue Lys to which a modifying group containing a carbonyl group binds, and X7 represents an amino acid residue such as Glu or Ala.

Abstract: The present invention provides oligopeptides having morphogenesis promoting activity and in particular, hair promoting activity. The oligopeptides may be in monomer form, monomer having a reactive substance bound form or as a polymer, such as a dimer including a homodimer; heterodimer; homotrimer; or heterodimer. The present invention also provides monoclonal antibodies that specifically recognize a 220 kDa antigen of epithelial new hair follicles; hybridomas producing such antibody; and methods and kits for assaying hair growth in mammalian subjects.

Abstract: The present invention provides oligopeptides having morphogenesis promoting activity and in particular, hair promoting activity. The oligopeptides may be in monomer form, monomer having a reactive substance bound form or as a polymer, such as a dimer including a homodimer; heterodimer; homotrimer; or heterotrimer. The present invention also provides antibodies, such as polyclonal and monoclonal antibodies, or fragments thereof, that specifically recognize a 220 kDa antigen of epithelial new hair follicles; hybridomas producing such monoclonal antibodies; and methods and kits for assaying hair growth in mammalian subjects using such antibodies.

Abstract: The present invention provides recombinant gene vectors and nucleic acid constructs which are capable of decreasing, reducing or suppressing the transcription/translation of LIP (transcription inhibitor protein), and in some examples, without affecting the transcription/translation of LAP (transcription activator). Such vectors and constructs are used in methods for increasing the ratio of LAP to LIP activity in a cell and for treating and/or ameliorating the symptoms of a disease or condition associated with the ratio of LAP to LIP. The present invention also provides methods for screening for agents that are capable of modifying the ratio of LAP to LIP activity in a cell or individual.

Abstract: The present invention provides oligopeptides having morphogenesis promoting activity and in particular, hair promoting activity. The oligopeptides may be in monomer form, monomer having a reactive substance bound form or as a polymer, such as a dimer including a homodimer; heterodimer; homotrimer; or heterodimer. The present invention also provides monoclonal antibodies that specifically recognize a 220 kDa antigen of epithelial new hair follicles; hybridomas producing such antibody; and methods and kits for assaying hair growth in mammalian subjects.

Abstract: A method for screening a substance having promoting activity on hair growth, which comprises the steps of bringing hair follicles in telogen into contact with a test substance, and judging that the substance tested is positive when the hair follicles in telogen are led to in anagen by the substance tested, wherein the judgment is carried out by detecting expression of Hacl-1 in the hair follicles.

Abstract: Disclosed herein are a modified epimorphin obtained by adding a hydrophilic peptide composed of 5 to 99 amino acids to at least one terminus of a polypeptide containing the functional domain of epimorphin, and a modified epimorphin composed of a polypeptide having a structure wherein a hydrophobic domain adjacent to the C-terminus of the whole-length epimorphin consisting of a coiled coil domain (1) on the N-terminal side, a functional domain (2) at the center, a coiled coil domain (3) on the C-terminal side and the hydrophobic domain (4) adjacent to the C-terminus has been deleted from the whole-length epimorphin, and at least part of amino acids have been deleted from the terminal side of at least one of the coiled coil domains (1) and (3) as well.

Abstract: Novel physiologically active substance designated as epimorphin which is capable of being expressed by a gene hybridizing with a gene probe composed of the base sequence complementary to part of the base sequence of Sequence ID No. 1 in Sequence Listing, and which is produced by mesenchymal cells derived from human or mouse, and which shows morphogenetic activity of epithelial tissue, and isoforms of the epimorphin, base sequences encoding them, modified epimorphin, in which hydrophobic region at the carboxy terminal of the epimorphin polypeptide has been deleted or replaced by non-hydrophobic polypeptide, and polyclonal antibody or monoclonal antibody produced by the use of a full length or a part of the epimorphin as an antigen are provided. The substances of the present invention can be used for elucidation of the mechanism of diseases caused by abnormal epithelium formation, diagnosis of such diseases, or development of therapeutic methods therefor.

Abstract: Novel physiologically active substance designated as epimorphin which is capable of being expressed by a gene hybridizing with a gene probe composed of the base sequence complementary to part of the base sequence of Sequence ID No. 1 in Sequence Listing, and which is produced by mesenchymal cells derived from human or mouse, and which shows morphogenetic activity of epithelial tissue, and isoforms of said epimorphin, base sequences encoding them, modified epimorphin, in which hydrophobic region at the carboxy terminal of said epimorphin polypeptide has been deleted or replaced by non-hydrophobic polypeptide, and polyclonal antibody or monoclonal antibody produced by the use of a full length or a part of said epimorphin as an antigen are provided. The substances of the present invention can be used for elucidation of the mechanism of diseases caused by abnormal epithelium formation, diagnosis of said diseases, or development of therapeutic methods therefor.