Patents by Inventor Yohei HISATA

Yohei HISATA has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Antibody against insoluble fibrin
    Patent number: 9429584
    Abstract: With the intention of providing an antibody which does not bind to fibrinogen and which has a high affinity for and a high specificity to insoluble fibrin, it is found that a site comprising the amino acids at positions 231 to 246 of the fibrinogen B? chain and a site comprising the amino acids at positions 232 to 246 of the fibrinogen ? chain are bound to each other in a fibrinogen molecule. Further, it is shown that when fibrinogen is converted to insoluble fibrin, the binding is released, and these sites are exposed. It is also found that antibodies obtained by immunization with these sites do not bind to fibrinogen and have high affinity for and high specificity to insoluble fibrin.
    Type: Grant
    Filed: February 27, 2014
    Date of Patent: August 30, 2016
    Assignee: NATIONAL CANCER CENTER
    Inventors: Yasuhiro Matsumura, Masahiro Yasunaga, Yohei Hisata
  • ANTIBODY AGAINST INSOLUBLE FIBRIN
    Publication number: 20160011217
    Abstract: With the intention of providing an antibody which does not bind to fibrinogen and which has a high affinity for and a high specificity to insoluble fibrin, it is found that a site comprising the amino acids at positions 231 to 246 of the fibrinogen B? chain and a site comprising the amino acids at positions 232 to 246 of the fibrinogen ? chain are bound to each other in a fibrinogen molecule. Further, it is shown that when fibrinogen is converted to insoluble fibrin, the binding is released, and these sites are exposed. It is also found that antibodies obtained by immunization with these sites do not bind to fibrinogen and have high affinity for and high specificity to insoluble fibrin.
    Type: Application
    Filed: February 27, 2014
    Publication date: January 14, 2016
    Applicant: National Cancer Center
    Inventors: Yasuhiro MATSUMURA, Masahiro YASUNAGA, Yohei HISATA