Patents by Inventor Yohei Hoashi
Yohei Hoashi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20220218617Abstract: Problem to be Solved Provided is a method for manufacturing a pharmaceutical preparation, which safely and simply enables uniformization of contents of a small amount of a drug. [Solution] The method for manufacturing the pharmaceutical preparation includes: using a liquid for dispensing, the liquid containing a drug; and a first application step of applying the drug to a surface of a tablet or a capsule by a dispensing method. In addition, a pharmaceutical preparation according to the present invention includes: a base; and a drug which is applied to a surface of the base by a dispensing method, and the base is a tablet or a capsule.Type: ApplicationFiled: April 21, 2020Publication date: July 14, 2022Applicant: NIPRO CORPORATIONInventors: Yoshio NAKANO, Tomohiro HAYASHIDA, Yohei HOASHI, Keisuke EDAMURA, Yuki ICHIKAWA
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Publication number: 20200214985Abstract: Pharmaceutical composition particle capable of masking an unpalatable taste and improvement in dissolution properties, an orally disintegrating tablet containing the pharmaceutical composition particle, and a method for manufacturing a pharmaceutical composition particle. The pharmaceutical composition particle includes a core particle containing a drug and a water-soluble gelling swelling substance; and an outer layer which contains a water-insoluble substance and constitutes a coating provided on the outer side of the core particle. The method for manufacturing includes: pulverizing a water-soluble gelling swelling substance to have an average particle diameter of 15 ?m or less; a core particle manufacturing step of mixing the water-soluble gelling swelling substance pulverized and a drug to manufacture a core particle; and an outer layer formation step of coating the core particle with a water-insoluble substance on the outer side of the core particle.Type: ApplicationFiled: August 20, 2018Publication date: July 9, 2020Applicants: NIPRO CORPORATION, ZENSEI PHARMACEUTICAL INDUSTRIES CO.,LTD.Inventors: Tomohiro HAYASHIDA, Yohei HOASHI, Shin IJITSU, Yoshio NAKANO, Junji YAMAZAKI, Katsuhisa INOUE, Atsushi AIZAWA
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Publication number: 20190083628Abstract: Provided are pharmaceutical composition particles which are capable of achieving both of masking of an unpalatable taste and improvement in dissolution properties; an orally disintegrating tablet including the pharmaceutical composition particles; and a method for manufacturing the pharmaceutical composition particles. Each of the pharmaceutical composition particles includes: a core particle containing a water-soluble gelling swelling substance; an intermediate layer containing a drug and coating an outside of the core particle; and an outer layer containing a water-insoluble substance and coating an outside of the intermediate layer. In addition, the orally disintegrating tablet includes the above-described pharmaceutical composition particles.Type: ApplicationFiled: February 21, 2017Publication date: March 21, 2019Applicants: NIPRO CORPORATION, ZENSEI PHARMACEUTICAL INDUSTRIES CO., LTD.Inventors: Tomohiro HAYASHIDA, Yohei HOASHI, Shin IJITSU, Yoshio NAKANO, Junji YAMAZAKI, Katsuhisa INOUE, Atsushi AIZAWA
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Publication number: 20190054029Abstract: Provided are pharmaceutical composition particles which are capable of achieving both of masking of an unpalatable taste and improvement in dissolution properties; an orally disintegrating tablet including the pharmaceutical composition particles; and a method for manufacturing the pharmaceutical composition particles. Each of the pharmaceutical composition particles includes: a drug-containing core particle; an intermediate layer containing a gelling swelling substance and coating an outside of the core particle; and an outermost layer containing a water-insoluble substance and coating an outside of the intermediate layer.Type: ApplicationFiled: February 21, 2017Publication date: February 21, 2019Applicants: NIPRO CORPORATION, ZENSEI PHARMACEUTICAL INDUSTRIES CO., LTD.Inventors: Tomohiro HAYASHIDA, Yohei HOASHI, Shin IJITSU, Yoshio NAKANO, Junji YAMAZAKI, Katsuhisa INOUE, Atsushi AIZAWA
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Patent number: 10195154Abstract: A method for easily producing orodispersible tablets that secure an eluting behavior of a principal agent in the digestive tract and mask unpleasant taste in the oral cavity is provided. Provided is a method for producing orodispersible tablets which includes mixing an additive to a principal agent to form principal agent particles as a granulation process, coating the principal agent particles with a coating agent to form coated particles as a coating process, and tableting the coated particles to form tablets as a tableting process, wherein the additive used in the granulation process contains a pH regulator, and the coating agent used in the coating process contains a pH-dependent polymer dissolving at pH 5 or more.Type: GrantFiled: June 8, 2012Date of Patent: February 5, 2019Assignee: Nipro CorporationInventors: Yohei Hoashi, Naohisa Katayama, Shunsuke Daidouji
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Publication number: 20170196816Abstract: A laser-printable tablet has: a tablet containing an optically unstable drug, a first cover layer that covers the tablet and contains a first color change-inducing oxide, and a second cover layer that covers the first cover layer and contains a second color change-inducing oxide, the concentration in which the second color change-inducing oxide is contained in the second cover layer being different from the concentration in which the first color change-inducing oxide is contained in the first cover layer.Type: ApplicationFiled: June 2, 2015Publication date: July 13, 2017Applicant: NIPRO CORPORATIONInventors: Yohei HOASHI, Shotaro IKUTA
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Publication number: 20150272889Abstract: It is an object to provide an orally disintegrating tablet produced by dry granulation and compression, having a hardness of 40 N or more, a disintegration time of 30 seconds or shorter, a friability of 0.1% or less, and an excellent feeling upon ingestion, that is capable of disintegrating with a small amount of water, having a rapid disintegration time, and being maintained stably in a tablet form, which could not been achieved by conventional procedures. Disclosed is an orally disintegrating tablet produced by dry granulation which contains a medicinal ingredient with silica, and sugar alcohol or/and sugar.Type: ApplicationFiled: April 6, 2015Publication date: October 1, 2015Inventors: Yohei Hoashi, Hirofumi Takeuchi
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Publication number: 20140093567Abstract: A method for easily producing orodispersible tablets that secure an eluting behavior of a principal agent in the digestive tract and mask unpleasant taste in the oral cavity is provided. Provided is a method for producing orodispersible tablets which includes mixing an additive to a principal agent to form principal agent particles as a granulation process, coating the principal agent particles with a coating agent to form coated particles as a coating process, and tableting the coated particles to form tablets as a tableting process, wherein the additive used in the granulation process contains a pH regulator, and the coating agent used in the coating process contains a pH-dependent polymer dissolving at pH 5 or more.Type: ApplicationFiled: June 8, 2012Publication date: April 3, 2014Applicant: NIPRO CORPORATIONInventors: Yohei Hoashi, Naohisa Katayama, Shunsuke Daidouji
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Publication number: 20120294947Abstract: Provided is an oral preparation that contains a medicinal component having an unpleasant taste and that has better qualities, for example, generation of an analogue can be reduced, better than oral preparations that are produced by conventional techniques and that contain a medicinal component having an unpleasant taste. This objective is achieved by adding a coating agent on the medicinal component and a disintegrator that has a carboxymethyl group.Type: ApplicationFiled: December 28, 2010Publication date: November 22, 2012Applicant: NIPRO CORPORATIONInventors: Kennichiro Kuninobu, Yohei Hoashi, Naohisa Katayama, Toshiya Kai
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Publication number: 20120004321Abstract: It is an object to provide an orally disintegrating tablet produced by dry granulation and compression, having a hardness of 40 N or more, a disintegration time of 30 seconds or shorter, a friability of 0.1% or less, and an excellent feeling upon ingestion, that is capable of disintegrating with a small amount of water, having a rapid disintegration time, and being maintained stably in a tablet form, which could not been achieved by conventional procedures. Disclosed is an orally disintegrating tablet produced by dry granulation which contains a medicinal ingredient with silica, and sugar alcohol or/and sugar.Type: ApplicationFiled: March 8, 2010Publication date: January 5, 2012Applicant: NIPRO CORPORATIONInventors: Yohei Hoashi, Hirofumi Takeuchi
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Publication number: 20090098607Abstract: The present invention provides a production method of a functional recombinant human hemoglobin, which comprises transforming a yeast of the genus Pichia with an expression vector containing a DNA encoding a human hemoglobin ?-chain (Hb?), which is under regulation of a promoter functional in a yeast of the genus Pichia, and an expression vector containing a DNA encoding a human hemoglobin ?-chain (Hb?), which is under regulation of a promoter functional in a yeast of the genus Pichia, culturing the yeast in a medium, and recovering the human hemoglobin from the obtained culture. The present invention also provides an expression vector containing AOX1 promoter, DNA encoding Hb?, terminator functional in a yeast of the genus Pichia, AOX1 promoter, DNA encoding Hb? and terminator functional in the yeast of the genus Pichia in this order from the upstream side in transcriptional direction.Type: ApplicationFiled: October 16, 2007Publication date: April 16, 2009Applicant: NIPRO CORPORATIONInventors: Keisuke NAKAJOU, Yohei HOASHI, Toshiya KAI, Tadayuki UNO, Masaki OTAGIRI
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Publication number: 20080311195Abstract: A basis particle comprises a basic or acidic basis particle coated by a water-insoluble coating film, wherein the water-insoluble coating film contains a substance that is acidic with respect to the basic basis or basic with respect to the acidic basis. According to the basis particles (i.e., a main ingredient or an active drug)of the present invention, it is possible to temporarily adjust pH occurring in the immediate proximity of the basis particles by using a coating film, elution of the basis particles is suppressed and superior elution is exhibited without dependence on bodily pH. It is also possible to mask tastes such as the bitterness of the basis and it is possible to ingest drugs without sensing any bitterness.Type: ApplicationFiled: April 8, 2008Publication date: December 18, 2008Applicant: NIPRO CORPORATIONInventors: Shiho SAKURAGI, Naomi Ohmichi, Yohei Hoashi, Naohisa Katayama, Toshiya Kai
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Publication number: 20080166769Abstract: Provided is a high-copy-number, high-expression vector capable of producing a protein having satisfactory functions and activity of the same level as that of a natural form of the protein, in a large quantity and in a simple manner. Also provided is a vector including: (A) a target gene or a cloning site of the target gene, (B) a sequence element necessary for the high copying of the target gene, (C) a sequence element necessary for the expression of the target gene and a methionine aminopeptidase gene; a method of producing the vector; a transformant having the vector introduced therein; and a process for producing a protein using the transformant.Type: ApplicationFiled: June 1, 2006Publication date: July 10, 2008Inventors: Tadayuki Uno, Yohei Hoashi, Naohisa Katayama, Toshiya Kai
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Patent number: 7342048Abstract: A bioabsorbable release-sustaining pharmaceutical formulation using a biodegradable release-sustaining base material which can prevent an effective component drug from being released too rapidly just after administration of the formulation and then allow continued release of the drug for at least one month at a defined rate, is provided. For the biodegradable release-sustaining base material, a lactic acid-glycolic acid copolymer (PLGA) with an adjusted distribution in molecular weight is used.Type: GrantFiled: April 25, 2006Date of Patent: March 11, 2008Assignee: Nipro CorporationInventors: Tatsuaki Miyaji, Makoto Sato, Tamaki Murayama, Yohei Hoashi, Hisae Saito, Takao Okada, Yukari Imamura, Yoshimichi Fujiyama
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Publication number: 20060246139Abstract: A bioabsorbable release-sustaining pharmaceutical formulation using a biodegradable release-sustaining base material which can prevent an effective component drug from being released too rapidly just after administration of the formulation and then allow continued release of the drug for at least one month at a defined rate, is provided. For the biodegradable release-sustaining base material, a lactic acid-glycolic acid copolymer (PLGA) with an adjusted distribution in molecular weight is used.Type: ApplicationFiled: April 25, 2006Publication date: November 2, 2006Applicant: NIPRO CORPORATIONInventors: Tatsuaki Miyaji, Makoto Sato, Tamaki Murayama, Yohei Hoashi, Hisae Saito, Takao Okada, Yukari Imamura, Yoshimichi Fujiyama