Patents by Inventor Yohei Kiyotsuka

Yohei Kiyotsuka has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20230121698
    Abstract: Provided herein are small molecule modulators of ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1), compositions comprising the compounds, and methods of using the compounds and compositions comprising the compounds.
    Type: Application
    Filed: December 23, 2020
    Publication date: April 20, 2023
    Inventors: Anthony PINKERTON, Eduard SERGIENKO, Yohei KIYOTSUKA, Katsuji KAGECHIKA, Yasunobu KUROSAKI, Yoshikazu ARAI, Masatoshi NAGAMOCHI, Koutaro ISHIBASHI
  • Patent number: 10040791
    Abstract: It has been found that a compound of the general formula (I) having an isoxazole skeleton has excellent inhibitory activity against mutant IDH1 protein and inhibits the production of 2-HG by this protein, while the compound is also capable of effectively inhibiting the growth of various tumors expressing the protein. In the formula, R1, R2, R3, Y, and Z are as defined in claim 1.
    Type: Grant
    Filed: October 1, 2015
    Date of Patent: August 7, 2018
    Assignees: Daiichi Sankyo Company, Limited, National Cancer Center
    Inventors: Shoichi Saito, Masao Itoh, Tetsunori Fujisawa, Hironao Saito, Yohei Kiyotsuka, Hideaki Watanabe, Hironori Matsunaga, Yoshiko Kagoshima, Tetsuya Suzuki, Yoko Ogawara, Kazuo Kitabayashi
  • Publication number: 20170313696
    Abstract: It has been found that a compound of the general formula (I) having an isoxazole skeleton has excellent inhibitory activity against mutant IDH1 protein and inhibits the production of 2-HG by this protein, while the compound is also capable of effectively inhibiting the growth of various tumors expressing the protein. In the formula, R1, R2, R3, Y, and Z are as defined in claim 1.
    Type: Application
    Filed: October 1, 2015
    Publication date: November 2, 2017
    Applicants: Daiichi Sankyo Company, Limited, National Cancer Center
    Inventors: Shoichi Saito, Masao Itoh, Tetsunori Fujisawa, Hironao Saito, Yohei Kiyotsuka, Hideaki Watanabe, Hironori Matsunaga, Yoshiko Kagoshima, Tetsuya Suzuki, Yoko Ogawara, Kazuo Kitabayashi