Patents by Inventor Yohko Akiyama
Yohko Akiyama has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 9486446Abstract: The present invention provides an orally-disintegrating solid preparation comprising fine granules showing controlled release of a pharmaceutically active ingredient, wherein the outermost layer of the fine granules is coated with a coating layer comprising hydroxypropylmethylcellulose and low-substituted hydroxypropylcellulose and breakage of the fine granules during tableting is suppressed.Type: GrantFiled: December 27, 2007Date of Patent: November 8, 2016Assignee: Takeda Pharmaceutical Company LimitedInventors: Takashi Kurasawa, Yasuko Watanabe, Yohko Akiyama
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Publication number: 20160128945Abstract: A controlled release preparation wherein the release of active ingredient is controlled, which releases an active ingredient for an extended period of time by staying or slowly migrating in the gastrointestinal tract, is provided by means such as capsulating a tablet, granule or fine granule wherein the release of active ingredient is controlled and a gel-forming polymer. Said tablet, granule or fine granule has a release-controlled coating-layer formed on a core particle containing an active ingredient.Type: ApplicationFiled: December 28, 2015Publication date: May 12, 2016Inventors: Yohko AKIYAMA, Takashi KURASAWA, Hiroto BANDO, Naoki NAGAHARA
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Patent number: 8980322Abstract: The present invention provides a controlled release composition showing release of an active ingredient (proton pump inhibitor) controlled in two or more steps at different release rates, which contains 1) a release-controlled part A capable of controlling release of the active ingredient to occur at a predetermined rate, 2) a release-controlled part B capable of controlling release of the active ingredient to occur at a predetermined rate lower than the release rate of the release-controlled part A, and where necessary, 3) a release-controlled part C capable of controlling release of the active ingredient to occur at a predetermined rate faster than the release rate of the release-controlled part B, wherein the release of the active ingredient from the release-controlled part B precedes the release of the active ingredient from the release-controlled part A (when release-controlled part C is contained, the release of the active ingredient from the release-controlled part C precedes the release of the activeType: GrantFiled: March 16, 2004Date of Patent: March 17, 2015Assignee: Takeda Pharmaceutical Company LimitedInventors: Naoki Nagahara, Keiko Miyamoto, Yohko Akiyama
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Patent number: 8784885Abstract: A controlled release preparation wherein the release of active ingredient is controlled, which releases an active ingredient for an extended period of time by staying or slowly migrating in the gastrointestinal tract, is provided by means such as capsulating a tablet, granule or fine granule wherein the release of active ingredient is controlled and a gel-forming polymer. Said tablet, granule or fine granule has a release-controlled coating-layer formed on a core particle containing an active ingredient.Type: GrantFiled: July 19, 2010Date of Patent: July 22, 2014Assignee: Takeda Pharmaceutical Company LimitedInventors: Yohko Akiyama, Takashi Kurasawa, Hiroto Bando, Naoki Nagahara
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Publication number: 20140186448Abstract: A controlled release preparation wherein the release of active ingredient is controlled, which releases an active ingredient for an extended period of time by staying or slowly migrating in the gastrointestinal tract, is provided by means such as capsulating a tablet, granule or fine granule wherein the release of active ingredient is controlled and a gel-forming polymer. Said tablet, granule or fine granule has a release-controlled coating-layer formed on a core particle containing an active ingredient.Type: ApplicationFiled: March 6, 2014Publication date: July 3, 2014Inventors: Yohko AKIYAMA, Takashi KURASAWA, Hiroto BANDO, Naoki NAGAHARA
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Publication number: 20140186449Abstract: A controlled release preparation wherein the release of active ingredient is controlled, which releases an active ingredient for an extended period of time by staying or slowly migrating in the gastrointestinal tract, is provided by means such as capsulating a tablet, granule or fine granule wherein the release of active ingredient is controlled and a gel-forming polymer. Said tablet, granule or fine granule has a release-controlled coating-layer formed on a core particle containing an active ingredient.Type: ApplicationFiled: March 6, 2014Publication date: July 3, 2014Inventors: Yohko AKIYAMA, Takashi KURASAWA, Hiroto BANDO, Naoki NAGAHARA
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Patent number: 8722084Abstract: A controlled release preparation wherein the release of active ingredient is controlled, which releases an active ingredient for an extended period of time by staying or slowly migrating in the gastrointestinal tract, is provided by means such as capsulating a tablet, granule or fine granule wherein the release of active ingredient is controlled and a gel-forming polymer. Said tablet, granule or fine granule has a release-controlled coating-layer formed on a core particle containing an active ingredient.Type: GrantFiled: July 8, 2010Date of Patent: May 13, 2014Assignee: Takeda Pharmaceutical Company LimitedInventors: Yohko Akiyama, Takashi Kurasawa, Hiroto Bando, Naoki Nagahara
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Publication number: 20100316709Abstract: The present invention provides an orally-disintegrating solid preparation comprising fine granules showing controlled release of a pharmaceutically active ingredient, wherein the outermost layer of the fine granules is coated with a coating layer comprising hydroxypropylmethylcellulose and low-substituted hydroxypropylcellulose and breakage of the fine granules during tableting is suppressed.Type: ApplicationFiled: December 27, 2007Publication date: December 16, 2010Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITEDInventors: Takashi Kurasawa, Yasuko Watanabe, Yohko Akiyama
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Publication number: 20100285120Abstract: A controlled release preparation wherein the release of active ingredient is controlled, which releases an active ingredient for an extended period of time by staying or slowly migrating in the gastrointestinal tract, is provided by means such as capsulating a tablet, granule or fine granule wherein the release of active ingredient is controlled and a gel-forming polymer. Said tablet, granule or fine granule has a release-controlled coating-layer formed on a core particle containing an active ingredient.Type: ApplicationFiled: July 19, 2010Publication date: November 11, 2010Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITEDInventors: Yohko Akiyama, Takashi Kurasawa, Hiroto Bando, Naoki Nagahara
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Publication number: 20100278911Abstract: A controlled release preparation wherein the release of active ingredient is controlled, which releases an active ingredient for an extended period of time by staying or slowly migrating in the gastrointestinal tract, is provided by means such as capsulating a tablet, granule or fine granule wherein the release of active ingredient is controlled and a gel-forming polymer. Said tablet, granule or fine granule has a release-controlled coating-layer formed on a core particle containing an active ingredient.Type: ApplicationFiled: July 8, 2010Publication date: November 4, 2010Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITEDInventors: Yohko Akiyama, Takashi Kurasawa, Hiroto Bando, Naoki Nagahara
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Publication number: 20100272798Abstract: A controlled release preparation wherein the release of active ingredient is controlled, which releases an active ingredient for an extended period of time by staying or slowly migrating in the gastrointestinal tract, is provided by means such as capsulating a tablet, granule or fine granule wherein the release of active ingredient is controlled and a gel-forming polymer. Said tablet, granule or fine granule has a release-controlled coating-layer formed on a core particle containing an active ingredient.Type: ApplicationFiled: July 8, 2010Publication date: October 28, 2010Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITEDInventors: Yohko AKIYAMA, Takashi KURASAWA, Hiroto BANDO, Naoki NAGAHARA
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Patent number: 7790755Abstract: A controlled release preparation wherein the release of active ingredient is controlled, which releases an active ingredient for an extended period of time by staying or slowly migrating in the gastrointestinal tract, is provided by means such as capsulating a tablet, granule or fine granule wherein the release of active ingredient is controlled and a gel-forming polymer. Said tablet, granule or fine granule has a release-controlled coating-layer formed on a core particle containing an active ingredient.Type: GrantFiled: October 15, 2003Date of Patent: September 7, 2010Assignee: Takeda Pharmaceutical Company LimitedInventors: Yohko Akiyama, Takashi Kurasawa, Hiroto Bando, Naoki Nagahara
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Publication number: 20060177509Abstract: The present invention provides a controlled release composition showing release of an active ingredient (proton pump inhibitor) controlled in two or more steps at different release rates, which contains 1) a release-controlled part A capable of controlling release of the active ingredient to occur at a predetermined rate, 2) a release-controlled part B capable of controlling release of the active ingredient to occur at a predetermined rate lower than the release rate of the release-controlled part A, and where necessary, 3) a release-controlled part C capable of controlling release of the active ingredient to occur at a predetermined rate faster than the release rate of the release-controlled part B, wherein the release of the active ingredient from the release-controlled part B precedes the release of the active ingredient from the release-controlled part A (when release-controlled part C is contained, the release of the active ingredient from the release-controlled part C precedes the release of the activeType: ApplicationFiled: March 16, 2004Publication date: August 10, 2006Inventors: Naoki Nagahara, Keiko Miyamoto, Yohko Akiyama
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Publication number: 20060039974Abstract: The sustained-release preparation of the present invention, which contains a dipeptidyl peptidase IV inhibitor and a hydrophilic polymer, can appropriately inhibit the DPP-IV activity, and is superior in convenience or compliance.Type: ApplicationFiled: September 10, 2003Publication date: February 23, 2006Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITEDInventors: Yohko Akiyama, Yukihiro Matsumoto, Satoru Oi, Nobuhiro Suzuki, Shigetoshi Tsubotani
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Publication number: 20060013868Abstract: A controlled release preparation wherein the release of active ingredient is controlled, which releases an active ingredient for an extended period of time by staying or slowly migrating in the gastrointestinal tract, is provided by means such as capsulating a tablet, granule or fine granule wherein the release of active ingredient is controlled and a gel-forming polymer. Said tablet, granule or fine granule has a release-controlled coating-layer formed on a core particle containing an active ingredient.Type: ApplicationFiled: October 15, 2003Publication date: January 19, 2006Inventors: Yohko Akiyama, Takashi Kurasawa, Hiroto Bando, Naoki Nagahara
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Publication number: 20040116522Abstract: The present invention relates to a pharmaceutical solution containing a physiologically active non-peptide substance, an organic acid and a biocompatible organic solvent, and provides a pharmaceutical solution wherein a physiologically active non-peptide substance is dissolved at a high concentration.Type: ApplicationFiled: September 25, 2003Publication date: June 17, 2004Inventors: Yutaka Yamagata, Yukihiro Matsumoto, Yohko Akiyama
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Publication number: 20040058956Abstract: Solid dispersions are provided comprising an HER2 inhibitor which is hardly or not soluble in water and a hydrophilic polymer. These solid dispersions have been improved in the solubility of the HER2 inhibitor, oral absorption and bioavailability in blood.Type: ApplicationFiled: June 3, 2003Publication date: March 25, 2004Inventors: Yohko Akiyama, Satoshi Iinuma, Hiroto Bando
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Publication number: 20040053936Abstract: An oral pharmaceutical composition of the present invention, which contains a compound having CCR5 antagonistic action dissolved or dispersed in an amphiphilic substance-containing carrier, shows less dispersion in the blood concentration of a compound having CCR5 antagonistic action or a salt thereof, shows extremely fine oral absorption, and makes a preparation for oral administration useful for the prophylaxis or treatment of various HIV infectious diseases in human.Type: ApplicationFiled: June 20, 2003Publication date: March 18, 2004Inventors: Yohko Akiyama, Naoki Nagahara
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Publication number: 20030078189Abstract: Medicinal compositions for oral use to be used as preparations for oral administration showing little scatter in the concentration of a compound, which is insoluble or slightly soluble in water and shows a CCR5 antagonism, or its salt in blood, having very high oral absorbability and being useful in preventing and treating various HIV infections in humans, characterized in that the above-described compound or its salt is dissolved or dispersed in a carrier containing at least one constituent selected from among amphipathic substances, alcohols and lipids.Type: ApplicationFiled: June 6, 2002Publication date: April 24, 2003Inventors: Yohko Akiyama, Naoki Nagahara, Yukihiro Matsumoto
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Publication number: 20020142041Abstract: A solid matrix composition which is solid at ambient temperature, which comprises a viscogenic agent, such as an acrylic acid polymer, capable of developing viscosity on contact with water, as dispersed at least in the neighborhood of the surface layer of a matrix particle containing a polyglycerol fatty acid ester or a lipid and an active ingredient. The matrix may be such that a matrix particle containing a polyglycerol fatty acid ester or a lipid and an active ingredient has been coated with a coating composition containing at least one viscogenic agent. Such composition can adhere to the digestive tract and remain there for a prolonged period of time, thereby increasing the bioavailability of the active ingredient. Solid preparations, such as fine granules and granules, contain the above matrix composition.Type: ApplicationFiled: February 20, 2002Publication date: October 3, 2002Inventors: Yohko Akiyama, Naoki Nagahara, Shin-ichiro Hirai