Patents by Inventor Yoichi Negishi

Yoichi Negishi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11566047
    Abstract: Provided is a peptide having a short chain length, for example, having the number of amino acid residues of 20 or less and having a high myostatin inhibitory activity. The present invention is a peptide comprising an amino acid sequence represented by Formula (1) in the specification and having the number of amino acid residues of 20 or less.
    Type: Grant
    Filed: August 8, 2017
    Date of Patent: January 31, 2023
    Assignee: TOKYO UNIVERSITY OF PHARMACY & LIFE SCIENCES
    Inventors: Yoshio Hayashi, Kentaro Takayama, Yoichi Negishi
  • Publication number: 20190177370
    Abstract: Provided is a peptide having a short chain length, for example, having the number of amino acid residues of 20 or less and having a high myostatin inhibitory activity. The present invention is a peptide comprising an amino acid sequence represented by Formula (1) in the specification and having the number of amino acid residues of 20 or less.
    Type: Application
    Filed: August 8, 2017
    Publication date: June 13, 2019
    Inventors: Yoshio HAYASHI, Kentaro TAKAYAMA, Yoichi NEGISHI
  • Patent number: 10060654
    Abstract: Heat pump type heating apparatus capable of performing a continuous dual-stage operation without stopping a high stage side compressor even when a return temperature of a heating medium reaches a prescribed high temperature and, thereby, improving a sense of being insufficiently warmed due to stoppage of the high stage side compressor or a sense of being insufficiently warmed due to execution of frequent defrosting operations. The heat pump type heating apparatus includes an internal heat exchanger (a second internal heat exchanger) that performs heat exchange between a low-temperature refrigerant on a low-pressure side of a low stage side refrigeration circuit and a high-temperature refrigerant on a high-pressure side of a high stage side refrigerant circuit, a bypass pipe bypassing the internal heat exchanger, and flow path control means that controls a refrigerant flow to each of the internal heat exchanger and the bypass pipe.
    Type: Grant
    Filed: July 2, 2015
    Date of Patent: August 28, 2018
    Assignee: SANDEN HOLDINGS CORPORATION
    Inventors: Yasunori Takayama, Hiroshi Ishida, Masato Sakai, Yoichi Negishi
  • Publication number: 20170227260
    Abstract: Heat pump type heating apparatus capable of performing a continuous dual-stage operation without stopping a high stage side compressor even when a return temperature of a heating medium reaches a prescribed high temperature and, thereby, improving a sense of being insufficiently warmed due to stoppage of the high stage side compressor or a sense of being insufficiently warmed due to execution of frequent defrosting operations. The heat pump type heating apparatus includes an internal heat exchanger (a second internal heat exchanger) that performs heat exchange between a low-temperature refrigerant on a low-pressure side of a low stage side refrigeration circuit and a high-temperature refrigerant on a high-pressure side of a high stage side refrigerant circuit, a bypass pipe bypassing the internal heat exchanger, and flow path control means that controls a refrigerant flow to each of the internal heat exchanger and the bypass pipe.
    Type: Application
    Filed: July 2, 2015
    Publication date: August 10, 2017
    Inventors: Yasunori TAKAYAMA, Hiroshi ISHIDA, Yuto SAKAI, Yoichi NEGISHI
  • Patent number: 9457102
    Abstract: To provide a technology for introducing a PMO with remarkably enhanced cell permeability, leading to significantly enhanced introduction efficiency to thereby provide a therapeutic drug that dramatically ameliorates a medical condition of DMD. Also provided is a therapeutic drug for Duchenne muscular dystrophy, including as an active ingredient a Bubble liposome having a specific morpholino oligomer (PMO) bound to a surface thereof, in which the PMO is introduced into a muscle fiber (muscle cell) of a muscle tissue with high efficiency by administration of the therapeutic drug into the muscle tissue or into a blood vessel followed by ultrasound irradiation to the muscle tissue transcutaneously.
    Type: Grant
    Filed: April 25, 2012
    Date of Patent: October 4, 2016
    Assignee: NEPA GENE CO., LTD.
    Inventors: Yoichi Negishi, Yoko Takahashi, Kazuo Maruyama, Yukihiko Aramaki
  • Publication number: 20140155813
    Abstract: To provide a technology for introducing a PMO with remarkably enhanced cell permeability, leading to significantly enhanced introduction efficiency to thereby provide a therapeutic drug that dramatically ameliorates a medical condition of DMD. Also provided is a therapeutic drug for Duchenne muscular dystrophy, including as an active ingredient a Bubble liposome having a specific morpholino oligomer (PMO) bound to a surface thereof, in which the PMO is introduced into a muscle fiber (muscle cell) of a muscle tissue with high efficiency by administration of the therapeutic drug into the muscle tissue or into a blood vessel followed by ultrasound irradiation to the muscle tissue transcutaneously.
    Type: Application
    Filed: April 25, 2012
    Publication date: June 5, 2014
    Applicant: NEPA GENE CO., LTD.
    Inventors: Yoichi Negishi, Yoko Takahashi, Kazuo Maruyama, Yukihiko Aramaki
  • Patent number: 5974330
    Abstract: A microcellular portable telephone displays one's location, data on the location of the base station and, a data table showing the interrelation between the base station identifier code and base station location data. Pressing a specified operating key converts the base station identifier code connected to the portable telephone into data on the location of the base station by referring to the data table. The location of the base station is shown on the display device by means of the converted data.
    Type: Grant
    Filed: December 4, 1996
    Date of Patent: October 26, 1999
    Assignee: Sony Corporation
    Inventor: Yoichi Negishi