Abstract: Methods and compositions are provided for determining TMB in a tumor sample using transcriptome profiling data. Also provided herein are methods and compositions for determining the response of an individual with a specific TMB to a therapy such as immunotherapy.

Abstract: The object of the present invention is to provide a reliable alkaline storage battery having a structure by which a short circuit between the electrodes can be prevented in the manufacturing procedures. To achieve this object, the present invention provides a cylindrical battery that includes an electrode assembly including a positive electrode plate and a negative electrode plate spirally wound together and sandwiching a separator. The collector plate includes a main body. One or more convex parts, each having a top extending linearly, are formed on a main surface of the main body by bending processing. A part of at least one of the convex part is cut out to form a cutout region. The collector plate is welded to the end part of the electrode assembly at the top of each convex part.

Abstract: In the present invention, the electrode assembly is first formed, and then a tab portion is formed by compressing an active material unfilled portion in an electrode having a foamed-metal electrode substrate (Tab Portion Formation Step). Accordingly, in the manufacturing method of the present invention, even if winding misalignment is created in which the edge of the separator is located adjacent to one edge of the active material unfilled portion during the formation of the electrode assembly, the misaligned portion of the separator is pushed in the width direction of the electrode together with the active material unfilled portion when the compression is applied in the Tab Portion Formation Step. Herewith, it is less likely to tuck a part of the separator between the tab portion and the current collector when the current collector is joined in the Current Collector Joining Step.

Abstract: The object of the present invention is to provide a reliable alkaline storage battery having a structure by which a short circuit between the electrodes can be prevented in the manufacturing procedures. To achieve this object, the present invention provides a cylindrical battery that includes an electrode assembly including a positive electrode plate and a negative electrode plate spirally wound together and sandwiching a separator. The collector plate includes a main body. One or more convex parts, each having a top extending linearly, are formed on a main surface of the main body by bending processing. A part of at least one of the convex part is cut out to form a cutout region. The collector plate is welded to the end part of the electrode assembly at the top of each convex part.

Abstract: A nickel electrode for an alkaline storage battery is made by filling a conductive porous member with an active material including a main active material layer substantially made of nickel hydroxide and containing cobalt in a state of a solid solution, and a compound layer containing at least one element selected from the group consisting of calcium, aluminum, strontium, scandium, yttrium, and lanthanoide series, the compound layer being formed on a surface of the main active material layer. A metal molar ratio of cobalt contained in the main active material layer to nickel contained in the main active material layer is in a range of 0.5% to 3.0%, and a metal molar ratio of the at least one element contained in the compound layer to nickel contained in the active material is in a range of 0.3% to 5.0%.

Abstract: A method of producing a nickel electrode for an alkaline storage battery, comprising: an active-material loading step comprising preparing an active-material loaded plate electrode by loading an active-material containing nickel hydroxide as its principal component into the pores of said porous electrically conductive substrate; an immersion step comprising immersing said active-material loaded plate electrode into an impregnation solution comprising an acid salt solution containing at least one element selected from the group consisting of Ca, Sr, Sc, Y, Al, Mn, and lanthanides; and an alkali treatment step comprising forming a hydroxide layer on the surface of the electrode plate by converting the acid salt into a hydroxide by immersing said plate electrode into an alkaline solution; provided that the temperature of the impregnation solution is controlled in a range of from 40 to 90° C., and that the pH value of impregnating solution is controlled to a range of from 4 to 6.

Abstract: A nickel electrode for alkaline storage battery of the invention comprises an electrically-conductive porous substrate coated with an oxide containing cobalt on the surface thereof and a positive active material coated with nickel and a compound selected from the group consisting of Ca, Sr, Sc, Y, Al, Mn and lanthanoids on the surface thereof. Thus, the coating of the surface of the active material with nickel and a compound containing Ca, Sr, Sc, Y, Al, Mn and lanthanoids causes the enhancement of the effect of increasing oxygen overvoltage at high temperature and hence the charge acceptability. Further, since the gap between the electrically-conductive porous substrate and the positive active material is filled with the oxide containing cobalt, the electrical conductivity thereof can be improved, making it possible to inhibit the deterioration of large current charge properties and large current discharge properties.

Abstract: A method of producing a nickel electrode for an alkaline storage battery, comprising: an active-material loading step comprising preparing an active-material loaded plate electrode by loading an active-material containing nickel hydroxide as its principal component into the pores of said porous electrically conductive substrate; an immersion step comprising immersing said active-material loaded plate electrode into an impregnation solution comprising an acid salt solution containing at least one element selected from the group consisting of Ca, Sr, Sc, Y, Al, Mn, and lanthanides; and an alkali treatment step comprising forming a hydroxide layer on the surface of the electrode plate by converting the acid salt into a hydroxide by immersing said plate electrode into an alkaline solution; provided that the temperature of the impregnation solution is controlled in a range of from 40 to 90° C., and that the pH value of impregnating solution is controlled to a range of from 4 to 6.

Abstract: A nickel electrode for an alkaline storage battery is made by filling a conductive porous member with an active material including a main active material layer substantially made of nickel hydroxide and containing cobalt in a state of a solid solution, and a compound layer containing at least one element selected from the group consisting of calcium, aluminum, strontium, scandium, yttrium, and lanthanoide series, the compound layer being formed on a surface of the main active material layer. A metal molar ratio of cobalt contained in the main active material layer to nickel contained in the main active material layer is in a range of 0.5% to 3.0%, and a metal molar ratio of the at least one element contained in the compound layer to nickel contained in the active material is in a range of 0.3% to 5.0%.