Patents by Inventor Yoji Mimaki

Yoji Mimaki has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 6046201
    Abstract: N-(12-Nitroxydodecyl)-6-(4-ethyl or isopropyl-1-piperazinyl)pyridine-3-carboxamide or physiologically acceptable salts thereof. The said compounds have excellent inhibiting activity of cerebral edema, especially ischemic cerebral edema, and inhibiting activity of delayed neuronal death (an inhibiting activity of Ca-influx in neuronal cells). Cerebral edema is a pathologic condition accompanying cerebrovascular disorders, especially the acute stage cerebrovascular disorders and then the compounds are useful as an inhibiting agent for cerebral edema or a therapeutic agent for cerebrovascular disorders. Moreover, because the compounds do hardly show a behavior suppressing action, which is considered to be side effect in treating cerebrovascular disorders at the acute stage, they are an excellent therapeutic agent for, in particular, the acute stage cerebrovascular disorders.
    Type: Grant
    Filed: July 15, 1998
    Date of Patent: April 4, 2000
    Assignee: Nisshin Flour Milling Co., Ltd.
    Inventors: Norio Oshida, Yoji Mimaki, Hiroaki Satoh, Shinji Yokoyama, Yukiko Muraki, Kazumi Nishimura, Tamiko Hamada, Einosuke Sakurai, Hiroshi Sakai, Toshiji Sugai, Tomomi Tonoike, Koichi Itoh
  • Patent number: 5972943
    Abstract: Pyridinecarboxamide derivatives of the formula ##STR1## (wherein n represents an integer of 14-18, and R represents a hydrogen atom or a straight or branched C.sub.1 -C.sub.4 alkyl group) or physiologically acceptable salts thereof. The compounds have excellent inhibiting activity of cerebral edema, especially ischemic cerebral edema, and inhibiting activity of delayed death of neuronal cells (an inhibiting activity of Ca-influx in neuronal cells). Cerebral edema is a pathologic condition accompanying cerebrovascular disorders, especially the acute stage of cerebrovascular disorders and then the compounds are useful as an agent for inhibiting cerebral edema or a therapeutic agent for cerebrovascular disorders. Moreover, the compounds have no hypotensive action which is considered to be side-effect in treating the acute stage cerebrovascular disorders and hardly show a behavior suppressing action so that they are an excellent therapeutic agent for, in particular, the acute stage cerebrovascular disorders.
    Type: Grant
    Filed: July 20, 1998
    Date of Patent: October 26, 1999
    Assignee: Nisshin Flour Milling Co., Ltd.
    Inventors: Norio Oshida, Yoji Mimaki, Hiroaki Satoh, Shinji Yokoyama, Yukiko Muraki, Kazumi Nishimura, Tamiko Hamada, Einosuke Sakurai, Hiroshi Sakai, Toshiji Sugai, Tomomi Tonoike, Koichi Itoh