Patents by Inventor Yoji Tachibana

Yoji Tachibana has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • 1-hydroxyvitamin D derivatives
    Patent number: 5182396
    Abstract: 1-Hydroxyvitamin D derivatives which are esters of 1-hydroxyvitamin D with vitamin A acid. They are useful for an agent for preventing and treating osteoporosis, cutaneous ulcer and tumor.
    Type: Grant
    Filed: March 25, 1992
    Date of Patent: January 26, 1993
    Assignee: Nisshin Flour Milling Co., Ltd.
    Inventor: Yoji Tachibana
  • 1.alpha.,25-dihydroxyvitamin D4 compounds, ergosta-5,7-diene compounds and processes for the preparation thereof
    Patent number: 5157135
    Abstract: (24S)- and (24R)-1.alpha.,25-Dihydroxyvitamin D.sub.4 compounds and processes for preparing same. Ergosta-5,7-diene compounds which are useful intermediates in the synthesis of the 1.alpha.,25-dihydroxyvitamin D.sub.4 compounds. The D.sub.4 compounds are expected to possess an interesting pharmacological activity in association with the active-type vitamins D.sub.3 and D.sub.2.
    Type: Grant
    Filed: March 21, 1990
    Date of Patent: October 20, 1992
    Assignee: Nisshin Flour Milling Co., Ltd.
    Inventors: Masahiro Tsuji, Yoji Tachibana, Shinji Yokoyama, Nobuo Ikekawa
  • Process for the preparation of 1.alpha.,25-dihydroxyvitamin D.sub.2 and the 24-epimer thereof
    Patent number: 5087709
    Abstract: (22E)-5,7,22-Ergostatriene-1.alpha.,3.beta.,25-triol and the 24-epimer thereof which are new intermediates for the synthesis of 1.alpha.,25-dihydroxyvitamin D.sub.2 and the 24-epimer thereof. A new process for the preparation of 1.alpha.,25-dihydroxyvitamin D.sub.2 and the 24-epimer thereof is also described which comprises irradiation of (22E)-5,7,22-ergostatriene-1.alpha.,3.beta.,25-triol or the 24-epimer thereof followed by isomerization.
    Type: Grant
    Filed: April 4, 1989
    Date of Patent: February 11, 1992
    Assignee: Nisshin Flour Milling Co., Ltd.
    Inventors: Masahiro Tsuji, Shinji Yokoyama, Yoji Tachibana
  • Ergosta-1,5,7,22-tetraen-3.beta.-ol and its use as an intermediate for 1.alpha.-hydroxy vitamin D.sub.2
    Patent number: 4758383
    Abstract: New processes for preparing new steroid derivatives including ergosta-1,5,7,22-tetraen-3.beta.-ol, 1.alpha.-hydroxyergosteryl diacetate, etc. which are useful intermediates in the synthesis of 1.alpha.-hydroxy vitamin D.sub.2. The processes include the new steps of reacting ergosta-1,4,6,22-tetraen-3-one with isopropenyl acetate in the presence of an acid catalyst followed by reduction to ergosta-1,5,7,22-tetraen-3.beta.-ol. The overall yield leading to 1.alpha.-hydroxy vitamin D.sub.2 is dramatically increased.
    Type: Grant
    Filed: November 4, 1987
    Date of Patent: July 19, 1988
    Assignee: Nisshin Flour Milling Co., Ltd.
    Inventor: Yoji Tachibana
  • Processes for preparing cholesta-1,5,7-trien-3-ol
    Patent number: 4723045
    Abstract: New processes for preparing cholesta-1,5,7-trien-3-ol which is a key intermediate in the synthesis of 1.alpha.-hydroxyvitamin D.sub.3. The processes utilize the steps of reacting cholesta-1,4,6-trien-3-one with isopropenyl acetate in the presence of an acid catalyst followed by reduction of the resultant cholesta-1,3,5,7-tetraen-3-yl-acetate.
    Type: Grant
    Filed: January 30, 1987
    Date of Patent: February 2, 1988
    Assignees: Nisshin Flour Milling Co., Ltd., Nisshin Chemicals Co., Ltd.
    Inventor: Yoji Tachibana