Patents by Inventor Yoko Funakoshi

Yoko Funakoshi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • FURANONE DERIVATES AND METHODS OF USE THEREOF
    Publication number: 20200055848
    Abstract: Herein disclosed are compounds, compositions, kits, and methods of treating cancers using 7-azaindolyl furanone/thiophene derivatives. These derivatives inhibit serine-threonine kinase Cdc7, a recognized anticancer target affecting DNA replication. Further, the compounds disclosed herein possess potent inhibitory activity in the presence of adenosine triphosphate (ATP), demonstrate significant kinase selectivity, and offer advantages over known Cdc7 inhibitors with prolonged half-life and inhibitory effects.
    Type: Application
    Filed: November 2, 2017
    Publication date: February 20, 2020
    Inventors: Takayuki IRIE, Ayako SAWA, Masaaki SAWA, Tokiko ASAMI, Yoko FUNAKOSHI, Chika TANIYAMA
  • Anticancer agent composition
    Patent number: 9974795
    Abstract: Provided is a pharmaceutical composition comprising a Cdc7 inhibitor and an M phase promoter. In particular, the Cdc7 inhibitor contained in the pharmaceutical composition is a furanone derivative represented by formula (I), or a pharmaceutically acceptable salt thereof. (In the formula, A is —COOR1 or a hydrogen atom; R1 is a hydrogen atom, an optionally substituted hydrocarbon group, or an optionally substituted heterocycle; R2 and R3 are the same or different and are each a hydrogen atom, an optionally substituted hydrocarbon group, an optionally substituted phenyl group, an optionally substituted heterocycle, an optionally substituted heterocyclic condensed ring, or an optionally substituted amino group. Alternatively, R2 and R3 may, together with the nitrogen atoms bonding the same, form an optionally substituted heterocycle or optionally substituted heterocyclic condensed ring. R4 is a hydrogen atom or halogen atom.
    Type: Grant
    Filed: January 26, 2015
    Date of Patent: May 22, 2018
    Assignee: CARNA BIOSCIENCES, INC.
    Inventors: Yoko Funakoshi, Chika Tanaka, Tokiko Asami, Masaaki Sawa
  • ANTICANCER AGENT COMPOSITION
    Publication number: 20170065609
    Abstract: Provided is a pharmaceutical composition comprising a Cdc7 inhibitor and an M phase promoter. In particular, the Cdc7 inhibitor contained in the pharmaceutical composition is a furanone derivative represented by formula (I), or a pharmaceutically acceptable salt thereof. (In the formula, A is —COOR1 or a hydrogen atom; R1 is a hydrogen atom, an optionally substituted hydrocarbon group, or an optionally substituted heterocycle; R2 and R3 are the same or different and are each a hydrogen atom, an optionally substituted hydrocarbon group, an optionally substituted phenyl group, an optionally substituted heterocycle, an optionally substituted heterocyclic condensed ring, or an optionally substituted amino group. Alternatively, R2 and R3 may, together with the nitrogen atoms bonding the same, form an optionally substituted heterocycle or optionally substituted heterocyclic condensed ring. R4 is a hydrogen atom or halogen atom.
    Type: Application
    Filed: January 26, 2015
    Publication date: March 9, 2017
    Inventors: Yoko FUNAKOSHI, Chika TANAKA, Tokiko ASAMI, Masaaki SAWA
  • Furanone derivative
    Patent number: 8742113
    Abstract: To provide a novel furanone derivative, and a medicine including the same.
    Type: Grant
    Filed: March 30, 2012
    Date of Patent: June 3, 2014
    Assignees: SBI Biotech Co., Ltd., Carna Biosciences, Inc.
    Inventors: Takayuki Irie, Ayako Sawa, Masaaki Sawa, Tokiko Asami, Yoko Funakoshi, Chika Tanaka
  • NOVEL FURANONE DERIVATIVE
    Publication number: 20140018533
    Abstract: To provide a novel furanone derivative, and a medicine including the same.
    Type: Application
    Filed: March 30, 2012
    Publication date: January 16, 2014
    Applicants: CARNA BIOSCIENCES, INC., SBI BIOTECH CO., LTD.
    Inventors: Takayuki Irie, Ayako Sawa, Masaaki Sawa, Tokiko Asami, Yoko Funakoshi, Chika Tanaka
  • AZAINDOLE DERIVATIVE
    Publication number: 20120135989
    Abstract: The present invention provides a (di)azaindole derivative represented by the formula (I). A compound of the present invention inhibits a Cdc7 protein kinase activity and suppresses cell proliferation.
    Type: Application
    Filed: June 29, 2011
    Publication date: May 31, 2012
    Applicants: CRYSTALGENOMICS, INC., SBI BIOTECH CO., LTD.
    Inventors: Yoko Funakoshi, Chika Tanaka, Choul Hong Park, Seong Gu Ro
  • Furanone derivative
    Patent number: RE46815
    Abstract: To provide a novel furanone derivative, and a medicine including the same.
    Type: Grant
    Filed: June 2, 2016
    Date of Patent: May 1, 2018
    Assignee: Carna Biosciences, Inc.
    Inventors: Takayuki Irie, Ayako Sawa, Masaaki Sawa, Tokiko Asami, Yoko Funakoshi, Chika Tanaka
  • Furanone derivative
    Patent number: RE48140
    Abstract: To provide a novel furanone derivative, and a medicine including the same.
    Type: Grant
    Filed: April 30, 2018
    Date of Patent: August 4, 2020
    Assignee: CARNA BIOSCIENCES, INC.
    Inventors: Takayuki Irie, Ayako Sawa, Masaaki Sawa, Tokiko Asami, Yoko Funakoshi, Chika Tanaka