Patents by Inventor Yoko Ishige

Yoko Ishige has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Factors mutated in the D1 cap region
    Patent number: 5939534
    Abstract: Human ciliary neurotrophic factor (human CNTF) mutants, in which at least the amino acid residue corresponding to position 153 of wild type human CNTF has been substituted with another amino acid residue in the amino acid sequence encoding human CNTF, exhibit an activity comparable or superior to that of wild type human CNTF. It is therefore expected that the human CNTF mutants would be effective as drugs with improved side effects such as reduction in appearance of an autoantibody, loss of body weight, anorexia, a dry cough, fatigue, etc.In cytokines having sequence similarity to human CNTF and abundant .alpha. helices (GH, PRL, EPO, G- CSF, LIF, IL-6, IL-2, IL-4, GM-CSF), there are further provided mutants in the D1 cap region.
    Type: Grant
    Filed: June 28, 1996
    Date of Patent: August 17, 1999
    Assignee: Sumitomo Pharmaceuticals Company, Limited
    Inventors: Makoto Inoue, Kaoru Kikuchi, Yoko Ishige, Akira Ito, Toru Kimura, Chikao Nakayama, Hiroshi Noguchi